Epididymal Leiomyoadenomatoid Tumor: A Case Report and Review of Literature

Abstract

Primary tumors of the epididymis are rare. Adenomatoid tumors are benign, usually found within the wall of fallopian tubes or beneath the uterine serosa. They are most frequently diagnosed as benign tumors of the epididymis and represent 30% of paratesticular tumors. The origin of this tumor is mesothelial cells. Leiomyoma are less common in the paratesticular localization. The origin of this tumor is smooth muscle cells. Clinically, these tumors are indistinctive with a painless mass of the scrotum. Here, we reported a case of combined leiomyoadenomatoid tumor. The histogenesis of this lesion remains unknown. This entity can be the result of a collision of the two tumors, or it can be a subtype of adenomatoid tumors with smooth muscle hyperplasia. This case showed the difficulty that occurs in the identification of this kind of lesion. Only one case of this entity in the epididymis was described in the literature. Leiomyoadenomatoid tumor is a benign neoplasm. In our case, this lesion was surgically removed in toto and no recurrence was observed.

A rare case of acute scrotum presenting as intraoperative surprise

“…Another opinion is that it is an adneomatoid tumour with reactive smooth muscle hyperplasia. Microscopically there are two components; first, the gland-like spaces lined with Correspondence: Vipin Venugopal Nair E-mail: vipinvenugopalnair@gmail.com https://orcid.org/0000-0002-8255-516X Received: 11-06-2021 Accepted: 04-08-2021 DOI: http://doi.org/10.4038/sljs.v39i3.8712 flattened or cuboidal cells as seen in this case, and secondly, the smooth muscle component with palisades of smooth muscle cells [4,5,6].…”

Diffuse WT1 Positivity in Smooth Muscle Component Supports Dual Differentiation of Mesothelial Cells in the Histogenesis of Leiomyoadenomatoid Tumors—A Report of two Cases

“…22 The diffuse nuclear WT1 positivity in both the adenomatoid and smooth muscle components in our study provides analogical evidence supporting the hypothesis that precursor cells with dual differentiation (mesothelial and muscular) give rise to the 2 different components. 23 Focal WT1 positivity in adenomatoid tumors with myofibroblastic and myoblastic proliferation has been previously reported. 11 However, the diffuse WT1 positivity observed in our study strongly suggests tunica vaginalis/paratesticular tissue origin via peculiar mesothelial differentiation.…”

Epididymal adenomatoid tumor: a case report and literature review

“…On microscopic examination, adenomatoid tumors appear with microcystic, angiomatoid or trabecular architecture, solid or macrocystic patterns are rarely reported [1,9]. The tumor's stroma is usually fibrous with scattered lymphocytes, but sometimes the stroma may have prominent smooth muscle tissue, leading some authors to name the lesion as leiomyoadenomatoid tumor [1,[19][20][21]. The cells vary from flattened to vacuolated with abundant cytoplasm.…”