Epididymo-Orchitis Caused by POM-1 Metallo-β-Lactamase-Producing Pseudomonas otitidis in an Immunocompetent Patient: Case Report and Molecular Characterization

Abstract

Pseudomonas otitidis is a rare and unique species among the Pseudomonas genus that has not been previously reported as a cause of male genitourinary tract infection. In this report, we describe a case of a 20-year-old immunocompetent male who presented with recurrent epididymo-orchitis, which was initially misidentified as Vibrio vulnificus and treated successfully. The causative agent could not be identified appropriately using the available routine methods, but a final identification was established using 16S rRNA targeted sequencing followed by whole-genome sequencing.

Pseudomonas otitidis bacteremia in an immunocompromised patient with cellulitis: case report and literature review

“…P. otitidis is a bacterium belonging to the Pseudomonas genus and was first identified as a pathogen associated with human ear infections in the United States in 2006 [ 1 ]. Initially reported as a causative agent of ear infections, such as acute and chronic otitis media, and acute otitis externa, recent reports have also shown associations with more invasive diseases, such as epididymo-orchitis, necrotizing fasciitis, and diffuse peritonitis [ 1 – 3 ], although clinical reports are limited. In 2021, the first case of bacteremia was reported [ 4 ].…”

“…Pseudomonas otitidis is a species of Pseudomonas bacteria that was first registered as a new species in the United States in 2006 and was initially reported as a cause of ear infections [ 1 ]. In recent years, it has been reported to cause more severe infections [ 2 , 3 ], and in 2021, bacteremia caused by P. otitidis was reported in an immunocompetent patient with COPD [ 4 ]. P. otitidis has characteristic drug susceptibility, showing sensitivity to penicillins and cephalosporins, while exhibiting a tendency for resistance to carbapenems due to the production of a species-specific metallo-β-lactamase, named POM-1 ( P. otitidis metallo-β-lactamase) [ 5 ].…”

Pseudomonas otitidis bacteremia in an immunocompromised patient with cellulitis: case report and literature review

“…Discussion and Conclusion P. otitidis a bacterium belonging to the Pseudomonas genus and was rst identi ed as a pathogen associated with human ear infections in the United States in 2006 [1]. Initially reported as a causative agent of ear infections, such as acute and chronic otitis media, and acute otitis externa, recent reports have also shown associations with more invasive diseases, such as epididymo-orchitis, necrotizing fasciitis, and diffuse peritonitis [1][2][3], although clinical reports are limited. In 2021, the rst case of bacteremia was reported [4].…”

“…Pseudomonas otitidis is a species of Pseudomonas bacteria that was rst registered as a new species in the United States in 2006 and was initially reported as a cause of ear infections [1]. In recent years, it has been reported to cause more severe infections [2,3], and in 2021, bacteremia caused by P. otitidis was reported in an immunocompetent patient with COPD [4]. P. otitidis has characteristic drug susceptibility, showing sensitivity to penicillin and cephalosporins, while exhibiting a tendency for resistance to carbapenems due to the production of a species-speci c metallo-β-lactamase, named POM-1 (P. otitidis metallo-β-lactamase) [5].…”