Epididymo-Orchitis following Intravesical Bacillus Calmette–Guérin Therapy

Menke, Jennifer J.; Heins, Jodi R

doi:10.1345/aph.19212

Cited by 27 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In any event, there has not yet been a report proving that BCG causes inflammation in the extravesical organ, because BCG is difficult to differentiate from other strains of M. bovis and other members of the M. tuberculosis complex by conventional methods 2,3 . On the other hand, it is interesting to note that granulomatous epididymitis should be considered as a late complication as in our case 5 . In this regard, Durek et al .…”

Section: Discussionmentioning

confidence: 65%

Epididymo‐orchitis caused by intravesically instillated bacillus Calmette‐Guérin: Genetically proven using a multiplex polymerase chain reaction method

Hano¹,

Seki

Shinojima³

et al. 2006

Int J of Urology

View full text Add to dashboard Cite

The intravesical instillation of bacillus Calmette-Guérin (BCG) is a standard therapy for superficial bladder carcinoma. Tuberculosis-like inflammation in the genitourinary tract is a serious complication of BCG. It can occur after a long interval from the cessation of the intravesical BCG therapy. If inflammation occurs, it is necessary to test whether the BCG strain has caused it or another mycobacterium species has. However, there has never been a report that proves BCG causes the inflammation, because BCG is difficult to differentiate from other strains of Mycobacterium bovis and other members of the Mycobacterium tuberculosis complex by conventional tests, including regular polymerase chain reaction (PCR). We first present a case of epididymo-orchitis, which developed 31 months after the cessation of BCG therapy, detected using a multiplex PCR method as having been caused by BCG. Our report illustrates the efficacy of this method to detect the responsible microbe that is thought to be transmitted from the instillated BCG strain.

show abstract

Section: Discussionmentioning

confidence: 65%

Epididymo‐orchitis caused by intravesically instillated bacillus Calmette‐Guérin: Genetically proven using a multiplex polymerase chain reaction method

Hano¹,

Seki

Shinojima³

et al. 2006

Int J of Urology

View full text Add to dashboard Cite

show abstract

“…A search of the MEDLINE database using the EBSCO search engine yielded up to 15 previously reported cases of epididymo-orchitis as a complication of intravesical BCG therapy [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] . The age range of the patients reported in these articles span between 54 and 83 years, which makes our patient the oldest reported case of BCG-related orchitis.…”

Section: Discussionmentioning

confidence: 99%

Multiparametric ultrasound findings of tuberculous orchitis following bacillus Calmette-Guérin therapy

Ahmed

Wolfe

Acher

et al. 2017

Radiology Case Reports

View full text Add to dashboard Cite

Granulomatous bacillus Calmette-Guérin (BCG) infection, both localized and disseminated, as a complication of intravesical therapy for transitional cell carcinoma of the bladder is a recognized but highly unusual phenomenon. We report the case of an 89-year-old gentleman with a history of bladder transitional cell carcinoma and subsequent intravesical BCG instillation of the bladder who presented to his general practitioner with a non-tender lump in his left testis. Histopathologic and microbiological evaluation of the subsequent orchidectomy specimen revealed granuloma formation secondary to BCG infection. The use of bubble contrast agents and elastography in ultrasound to evaluate focal testicular lesions is a relatively novel concept, and we aim to highlight the imaging features of testicular BCG infection using these techniques.

show abstract

“…Na tuberkulozni epididimitis mora da se posumnja kod svih pacijenata, koji su bili izloženi bacilu tuberkuloze ili boluju od pluénog oblika tuberkuloze, kao i kod onih koji ne reaguju na uobičajenu antibiotsku terapiju. Uz to, urolog bi morao da prepozna epididimoorhitis uzrokovan BCG vakcinom, koji može da se pojavi nakon liječenja površinskog karcinoma mokraćnog mjehura [22].…”

Section: Infektivni Epididimitisunclassified

Epididymitis: Diagnosis and treatment

D¹,

Miličević²,

Pajovic³

et al. 2007

Scripta Medica

View full text Add to dashboard Cite

Sažetak. Epididimitis se veoma često dijagnostikuje и ordinaciji urologa. Nekoliko je uzroka koji dovode do zapaljenja epididimisa: infekcija, trauma, autoimune bolesti, vaskultisi, a vrlo često oni ostaju nepoznati, pa se govori о idiopatskom epididimitisu. Epididimitis se može klasifikovati kao akutni (traje do 6 sedmica) ili hronični (traje 6 i vise sedmica). Dijagnoza se postavlja na osnovu kliničke slike, uz dodatne tehnike vizualizacije (imaging) kojima Ы trebalo da se razlikuje epididimitis od torzije testisa. Mada se uobičajeno smatra da je epididimitis infektivni procès, kod većine muškaraca sa epididimitisom ne može da se utvrdi infektivni uzročnik. Danas su određene preporuke za terapiju akutnog infektivnog epididimitisa, mada ih urolozi и mnogim slučajevima ne primjenjuju. Liječenje hroničnog epididimitisa je teško, a odgovor na terapiju je različit i и velikoj mjeri individualno zavisan, zbog čega su potrebna dodatna istraživanja ovog čestog urološkog stanja, kako bi se, prije svega, poboljšali rezultati terapije.

show abstract

Epididymo-Orchitis following Intravesical Bacillus Calmette–Guérin Therapy

Abstract: Epididymo-orchitis should be considered as a late complication of BCG therapy for bladder cancer. Proper patient selection may help decrease the risk of complications from BCG therapy.

Cited by 27 publications

References 15 publications

Epididymo‐orchitis caused by intravesically instillated bacillus Calmette‐Guérin: Genetically proven using a multiplex polymerase chain reaction method

Epididymo‐orchitis caused by intravesically instillated bacillus Calmette‐Guérin: Genetically proven using a multiplex polymerase chain reaction method

Multiparametric ultrasound findings of tuberculous orchitis following bacillus Calmette-Guérin therapy

Epididymitis: Diagnosis and treatment

Contact Info

Product

Resources

About