Epidoxorubicin and high dose leucovorin plus 5-fluorouracil in advanced gastric cancer

Adjuvant chemotherapy after gastric resection in node-positive cancer patients: a multicentre randomised study

“…Some preliminary data of ours (Neri et al, 1992) had pointed to the ineffectiveness of post-surgical adjuvant chemotherapy in terms of disease-free interval and survival, for patients who at the time of surgery proved to be node negative. Since the presence of lymph node involvement is a highly unfavourable prognostic factor (Michelassi et al, 1994) Fink et al, 1993;Rougier et al, 1994), so much so that preoperative chemotherapy appears to be an attractive tool for clinical investigation in earlier stages of gastric cancer (Wils et al, 1994).…”

“…However, the modulation of 5-FU by folinic acid has led to the testing of promising new combinations in advanced gastric cancer (Murad et al, 1993;Neri et al, 1993).…”

“…In addition, the combination of etoposide, doxorubicin and cisplatin (EAP) as well as the biochemical modulation of 5-FU activity by the addition of leucovorin (Bruckner et al, 1991;Kornek et al, 1992) have proved highly efficacious. Recently, in a phase II study of advanced gastric cancer treated with epidoxorubicin and high-dose leucovorin plus 5-FU (EPI -LV-5-FU), we obtained a response rate of 49% and a median response duration of 13 months with a very low general toxicity (Neri et al, 1993). These data would lead one to suppose that treatments found to be active in advanced disease might also be tested as adjuvant therapy in resectable gastric cancer.…”

“…Promising results with the EPI -LV -5-FU combination in advanced gastric cancer (Neri et al, 1993) (Simon, 1985), and an interim analysis after 36 months of follow-up adequate to reveal whether or not median survival could be doubled.…”

Epidoxorubicin and Double Biochemical 5-Fluorouracil Modulation with Folinic Acid and Human Lymphoblastoid Interferon in Advanced Gastric Carcinoma: A Multicentric Phase II Study of the Southern Italy Oncology Group (GOIM)

“…As reported in the literature, FU modulated by FA appears to be effective in advanced gastric tumors [7][8][9][10][11], The addition ofEPI at 50-75 mg/m2 to theFA-FU combi nation regimen resulted in objective response rates of 37 and 49% with mild toxicity in two different series [29,30]. In the series reported by Neri et al [30], the median survival of responder patients was 17.3 months in con trast to 8.7 months for nonresponding cases (p < 0.001).…”