Epidural malignant lymphomas of the spine: collected experiences with epidural malignant lymphomas of the spinal canal and their treatment

Abstract

Subjects and methods: The epidural presentation in eight patients was heralded by motor signs (paraparesis and plegia), in one by a lesion of the posterior columns of the spinal cord (ataxia), and in three by pain. One patient was free of complaints and symptoms. The affected epidural area was diagnosed previously by myelography and computerized tomography (CT), and later by magnetic resonance (MR), over the course of which the location was verified as thoracic in eight patients, cervical in one, and lumbar in four. The authors recommended surgical intervention in 9 out of 13 cases, in seven cases of Hodgkin's and six cases of non-Hodgkin's lymphoma. Seven patients were treated for recognized manifestations of malignant lymphoma while six were diagnosed by intraoperativehistological examination. Results and conclusion: The decompression operations for tumors resulted in limited improvement in seven patients (reduction in pain and return of ability to walk). Four patients were not operated on, two of which had significant improvement in their neurological symptoms. Paraparesis remained unchanged in one patient. One patient remained symptom-free. The authors emphasize the importance of interdisciplinary consultation and weighing individual priorities in the indications for operation on epidural ML.

Primary non-Hodgkin's lymphoma of the spine with neurologic compression treated by radiotherapy and chemotherapy alone or combined with surgical decompression

“…This indicated that rapid initiation of combined treatment is essential to achieve recovery of neurologic function. Besides neurologic decompression, the fundamental goal of treatment is life extension of the patients with the best quality of life (24). As it was impossible to resect the lesion entirely, the role of surgery in primary lymphoma of bone is limited.…”

A Rare Entity in the Lumbar Epidural Region: T-Cell Lymphoblastic Lymphoma

“…Spinal epidural involvement has been reported in 0.8%-2.8% of all malignant lymphoma cases 7 and is most commonly present in the thoracic spine, followed by the cervical spine and less commonly in the lumbar spine. 8 These regions are may be the first site for a primary tumor, 2,9 or may be the area for a metastasis 10 while the disease is progressing.…”

Extranodal lymphomas in adults in Szabolcs-Szatmár-Bereg county, Hungary. Analysis of the epidemiologic data of a thirty-year period

“…Váróczy és mtsai klinikájuk 1996-2005 közötti beteganyagát bemutató dolgozatukban nem területi regiszter, hanem intézményi regiszterük adatait elemzik [8]. Idézett dolgozatuktól és az időnként felbukkanó esetbemutatásoktól eltekintve az extranodalis NHL-ek saját tapasztalatokat közreadó hazai irodalma lényegé-ben egy-egy szerv vagy szervrendszer lymphomás érin-tettségének az ismertetésére korlátozódik [9,10,11,12,13,14,15,16,17,18,19,20,21,22].…”

“…Egyre gyakoribb megjelenésük megyénkben is megfi gyelhető. Évi átlagos számuk a vizsgált időszak első évtizedében (1983-1992) 5,5, a máso-dikban (1993-2002) ennek kétszerese (11,9) [3].…”