Epidural needle with embedded optical fibers for spectroscopic differentiation of tissue: ex vivo feasibility study

Desjardins, Adrien E.; Hendriks, Benno H. W.; Voort, Marjolein van der; Nachabé, Rami; Bierhoff, Walter; Braun, Guus; Babić, Draženko; Rathmell, James P.; Holmin, Staffan; Söderman, Michael; Holmström, Björn

doi:10.1364/boe.2.001452

Cited by 39 publications

(28 citation statements)

References 30 publications

(32 reference statements)

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“…Second, the PMMA light guides had prominent absorption peaks in the visible range and the very low transmission made impractical for wavelengths greater than 1000 nm. Prominent absorption spectra at 1210 nm were previously shown to be relevant for guiding a spinal needle into the epidural space [9] and it is likely that they could be advantageous for catheter guidance as well. The limitations of PMMA could potentially be overcome with certain perfluorinated plastic optical fibers that allow for transmission at wavelengths up to 1300 nm [23].…”

Section: Discussionmentioning

confidence: 99%

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Epidural catheter with integrated light guides for spectroscopic tissue characterization

Soto-Astorga

West

Putnis

et al. 2013

Biomed. Opt. Express

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Epidural catheters are used to deliver anesthetics and opioids for managing pain in many clinical scenarios. Currently, epidural catheter insertion is performed without information about the tissues that are directly ahead of the catheter. As a result, the catheter can be incorrectly positioned within a blood vessel, which can cause toxicity. Recent studies have shown that optical reflectance spectroscopy could be beneficial for guiding needles that are used to insert catheters. In this study, we investigate the whether this technique could benefit the placement of catheters within the epidural space. We present a novel optical epidural catheter with integrated polymer light guides that allows for optical spectra to be acquired from tissues at the distal tip. To obtain an initial indication of the information that could be obtained, reflectance values and photon penetration depth were estimated using Monte Carlo simulations, and optical reflectance spectra were acquired during a laminectomy of a swine ex vivo. Large differences between the spectra acquired from epidural adipose tissue and from venous blood were observed. The optical catheter has the potential to provide realtime detection of intravascular catheter placement that could reduce the risk of complications.

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Section: Discussionmentioning

confidence: 99%

“…Recently, several studies [7][8][9][10] have investigated the use of optical reflectance spectroscopy to guide the placement of needles into the epidural space. With this technique, integrated optical fibers deliver light to tissue at the distal end of the needle and receive a portion of the reflected light.…”

Section: Introductionmentioning

confidence: 99%

Epidural catheter with integrated light guides for spectroscopic tissue characterization

Soto-Astorga

West

Putnis

et al. 2013

Biomed. Opt. Express

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“…The small size of optical fibers, their capability of providing intrusive sensing operation [4][5][6], and their straightforward interrogation in spectral or amplitude mode [7], has prompted further investigation into their use in functional sensing schemes covering the above horizontal and vertical applications. While the sensitivity of such types of photonic sensors is always the first parameter to be considered-usually expressed as wavelength shift of nm/RIU (RIU: refractive index units), corresponding to specific spectral features of the sensor monitored-, one parameter that predominantly affects the practical implementation of those sensors and their potential commercialization is selectivity.…”

Section: Introductionmentioning

confidence: 99%

A Fiber Optic Fabry–Perot Cavity Sensor for the Probing of Oily Samples

Melissinaki

Farsari

Pissadakis

2017

Fibers

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Abstract:A micro-optical Fabry-Perot cavity fabricated by non-linear laser lithography on the endface of a standard telecom fiber is tested here as a microsensor for identifying oily liquids. The device operates within the 1550 nm spectral region, while the spectra recorded in reflection mode correlate to the refractive index of the oily liquids used, as well as, to the diffusion dynamics in the time domain of the oily samples inside the porous photo-polymerized sensing head. The operation of the microresonator sensing probe is explained by using a three-layer Fabry-Perot model and basic diffusion physics to estimate diffusivities for three series of refractive index matching oils with different chemical compositions that had been used in those experiments. The distinct spectro-temporal response of this sensing probe to the different oil samples is demonstrated and discussed.

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“…Reflectance spectroscopy probes that are integrated into needles [2,3] and catheters [4] can provide information about the spatial distributions of tissue chromophore concentrations such as hemoglobin and lipid that is complementary to conventional B-mode ultrasound images. In a typical implementation, light is delivered to Imaging probe tissue with one optical fiber and a portion of the reflected light is received with one or more adjacent fibers.…”

Section: Introductionmentioning

confidence: 99%

Fiber optic photoacoustic probe with ultrasonic tracking for guiding minimally invasive procedures

Xia¹,

Mosse²,

Colchester³

et al. 2015

Opto-Acoustic Methods and Applications in Biophotonics II

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In a wide range of clinical procedures, accurate placement of medical devices such as needles and catheters is critical to optimize patient outcomes. Ultrasound imaging is often used to guide minimally invasive procedures, as it can provide real-time visualization of patient anatomy and medical devices. However, this modality can provide low image contrast for soft tissues, and poor visualization of medical devices that are steeply angled with respect to the incoming ultrasound beams. Photoacoustic sensors can provide information about the spatial distributions of tissue chromophores that could be valuable for guiding minimally invasive procedures. In this study, a system for guiding minimally invasive procedures using photoacoustic sensing was developed. This system included a miniature photoacoustic probe with three optical fibers: one with a bare end for photoacoustic excitation of tissue, a second for photoacoustic excitation of an optically absorbing coating at the distal end to transmit ultrasound, and a third with a Fabry-Pérot cavity at the distal end for receiving ultrasound. The position of the photoacoustic probe was determined with ultrasonic tracking, which involved transmitting pulses from a linear-array ultrasound imaging probe at the tissue surface, and receiving them with the fiber-optic ultrasound receiver in the photoacoustic probe. The axial resolution of photoacoustic sensing was better than 70 µm, and the tracking accuracy was better than 1 mm in both axial and lateral dimensions. By translating the photoacoustic probe, depth scans were obtained from different spatial positions, and two-dimensional images were reconstructed using a frequency-domain algorithm.

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Epidural needle with embedded optical fibers for spectroscopic differentiation of tissue: ex vivo feasibility study

Cited by 39 publications

References 30 publications

Epidural catheter with integrated light guides for spectroscopic tissue characterization

Epidural catheter with integrated light guides for spectroscopic tissue characterization

A Fiber Optic Fabry–Perot Cavity Sensor for the Probing of Oily Samples

Fiber optic photoacoustic probe with ultrasonic tracking for guiding minimally invasive procedures

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