Epidural vs intramuscular administration of lecirelin, a GnRH analogue, for the resolution of follicular cysts in dairy cows

Annalisa, Rizzo; Campanile, Debora; Mutinati, Maddalena; Minoia, Giuseppe; Spedicato, Massimo; Luigi, Sciorsci Raffaele

doi:10.1016/j.anireprosci.2011.04.013

Cited by 11 publications

(2 citation statements)

References 25 publications

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“…Altogether, an intriguing opportunity to try to overcome this low response to GnRH, particularly in Bos indicus cattle, could then be to increase the dose of GnRH. Alternatively, the low response of LH release to GnRH treatment in Bos indicus may suggest that the blood-brain barrier in these cattle breeds is less permeable to the GnRH molecule when given intramuscularly and further investigation addressing whether GnRH given directly into the spinal cord fluid [33] could bring important insights on this plausible question. Additionally, LH storage can perhaps be depleted sooner in Bos indicus cattle following a gonadotropin release stimulus.…”

Section: Discussionmentioning

confidence: 99%

The effect of circulating progesterone on magnitude of the GnRH-induced LH surge: Are there any differences between Bos indicus and Bos taurus heifers?

Batista¹,

Valle²,

Ortolan³

et al. 2017

Theriogenology

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This study evaluated the effects of differing circulating progesterone (P4) levels on the luteinizing hormone (LH) surge profile following treatment with gonadotropin releasing hormone (GnRH) in B. indicus (Nelore, n = 13) and B. taurus (Holstein, n = 16) heifers. All heifers were synchronized with a hormonal protocol to induce either a Low or High circulating P4 environment at the time of GnRH treatment. Heifers were randomly assigned to a 2 × 2 factorial design composed by two genetic groups (B. indicus and B. taurus) and two levels of circulating P4 concentrations (Low or High). Blood samples were collected every 30 min from -30 to 210 min and at 270 min after GnRH treatment. As expected, mean P4 concentration was greater for cows in the High than in the Low P4 group (P = 0.0008) and in Bos indicus than in Bos taurus heifers (P = 0.06). Despite genetic group, the area under the curve of LH release was greater in the Low-P4 than in High-P4 concentration group (P < 0.0001). Interestingly, it appears that High P4 concentrations had a more pronounced effect on LH peak in B. indicus than in B. taurus heifers, as indicated by the interaction (P = 0.01) between genetic group and P4 levels. In conclusion, circulating P4 concentration have a great impact on the GnRH-induced LH surge of both B. indicus and B. taurus heifers, but it does not explain the much lower LH peak in B. indicus with low circulating P4. Thus, more studies are essential to uncover some of the underlying physiological factors other than circulating P4 that are limiting LH release following a GnRH treatment in B. indicus cattle.

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Section: Discussionmentioning

confidence: 99%

The effect of circulating progesterone on magnitude of the GnRH-induced LH surge: Are there any differences between Bos indicus and Bos taurus heifers?

Batista¹,

Valle²,

Ortolan³

et al. 2017

Theriogenology

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“…There has also been a recommendation to treat cows with 21 µg of buserelin intramuscularly for beneficial therapeutic effects in dairy cows [ 89 ]. The administration of lecirelin via epidural administration has shown a beneficial impact on reproductive parameters in treating follicular cysts [ 90 ]. The intramuscular administration of lecirelin (0.1 mg) has been reported as an effective therapy for ovarian cysts in dairy cows that are over 90 days postpartum following confirmation of the presence of a cystic follicle (>20 mm in diameter) [ 91 ].…”

Section: Gnrh and Cystic Ovarian Disease (Cod) “Follicular Cyst”mentioning

confidence: 99%

Gonadotropin-Releasing Hormone (GnRH) and Its Agonists in Bovine Reproduction II: Diverse Applications during Insemination, Post-Insemination, Pregnancy, and Postpartum Periods

Hassanein,

Szelényi,

Szenci

2024

Animals

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The administration of GnRH and its agonists benefits various aspects of bovine reproductive programs, encompassing physiological stages such as estrous synchronization, post-insemination, pregnancy, and the postpartum period. The positive impact of GnRH administration in overcoming challenges like repeat breeder cows, early embryonic loss prevention, and the management of cystic ovarian disease (COD) is thoroughly surveyed. Furthermore, this review focuses on the significance of GnRH administration during the postpartum period, its role in ovulation induction, and how it enhances the productivity of embryo transfer (ET) programs. An emerging feature of this field is introduced, focusing on nano-drug delivery systems for GnRH agonists, and the potential benefits that may arise from such advancements are highlighted. While this review offers valuable insights into various applications of GnRH in bovine reproduction, it emphasizes the crucial need for further research and development in this field to advance reproductive efficiency and health management in dairy cattle.

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Cystic ovarian follicles and thyroid activity in the dairy cow

Mutinati

Rizzo

Sciorsci

2013

Animal Reproduction Science

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Epidural vs intramuscular administration of lecirelin, a GnRH analogue, for the resolution of follicular cysts in dairy cows

Cited by 11 publications

References 25 publications

The effect of circulating progesterone on magnitude of the GnRH-induced LH surge: Are there any differences between Bos indicus and Bos taurus heifers?

The effect of circulating progesterone on magnitude of the GnRH-induced LH surge: Are there any differences between Bos indicus and Bos taurus heifers?

Gonadotropin-Releasing Hormone (GnRH) and Its Agonists in Bovine Reproduction II: Diverse Applications during Insemination, Post-Insemination, Pregnancy, and Postpartum Periods

Cystic ovarian follicles and thyroid activity in the dairy cow

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