Epigallocatechin-3-gallate alleviates galactose-induced aging impairment <i>via</i> gut–brain communication

Luo, Yi; Tang, Xiaofang; Zhang, Yichi; Chen, Su-Mei; Wu, Qiong; Li, Wenjuan

doi:10.1039/d2fo00994c

Cited by 9 publications

(5 citation statements)

References 36 publications

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“…A key observation of growth and development in mice is the change in body weight, while the degree of cellular senescence can be reflected by the organ index. Numerous studies have observed significant decreases in the organ indices of immune organs in aging mice [15]. In our study, the organ indices of mice in the model group were significantly lower than those of the other groups, and the organ indices of brain, liver and spleen in the dagliflozin intervention group showed significant increases compared to those of the senescent group.…”

Section: Discussioncontrasting

confidence: 38%

Protective Effect of SGLT2 Inhibitor on D-Galactose-Induced Senescence in Mice and Its Mechanism

Ma¹,

Xu²,

Jin³

et al. 2023

JBM

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Objective: To observe the cerebral protective effect of dagliflozin, a sodium-glucose co-transport protein 2 (SGLT2) inhibitor, in aging mice and to explore its molecular mechanism. Methods: 1. 66 male C57BL/6 mice were divided into control group (13) and model group ( 53), and the model group was moulded by subcutaneous injection of D-galactose into the back of the neck, while the control group was treated with equal amount of saline for 8 weeks. The weight of each group of mice was observed and recorded every 7 days, and two groups of mice were randomly selected for frozen sections of brain tissue at the end of the modelling period to verify the aging model. 2. After the aging model was successfully established, the aging groups were divided into 5 groups: model group, dagliflozin-treated group (high and low dose), and dagliflozin + ex527-inhibited group (high and low dose). Fasting blood glucose was measured in each group every 2 weeks for 8 weeks. At the end of treatment, Morris water maze was performed at the end of the treatment. After execution of the mice, the organ indices of heart, brain, liver, kidney and spleen were measured; the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in serum were determined. Results: After the successful establishment of the aging model, it was found that during the treatment phase of dagliflozin. 1) The organ indices of mice in the aging group were significantly lower than those of other groups, and no significant hypoglycemia was observed throughout the treatment process. 2) In the water maze test, mice in the aging group had a significantly longer latency in the plateau phase compared to the control and treatment groups, while the number of times the mice crossed the original plateau and the percentage of time spent exploring the original plateau quadrant were reduced after the plateau was removed. 3

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Section: Discussioncontrasting

confidence: 38%

Protective Effect of SGLT2 Inhibitor on D-Galactose-Induced Senescence in Mice and Its Mechanism

Ma¹,

Xu²,

Jin³

et al. 2023

JBM

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“…When the gut homeostasis is compromised, anti-inflammatory molecules such as SCFAs are decreased and an imbalance occurs with levels of pro-inflammatory molecules (e.g., LPS or biofilm amyloid fibres) [97,98] resulting in greater permeability of the intestinal wall, increased mitochondrial ROS production, neuronal peroxisome proliferation, as well as neurotoxin aggregation and, potentially, neurodegeneration. The decline in free radicals in the brain, through the reduction of oxidation by the modulation of the gut microbiome with the consumption of (poly)phenolic compounds, is reflected by the decrease in the level of malondialdehyde (MDA) and ROS, which is concordant with the changes in SCFAs production or the increase in SCFA-producing bacteria in several studies [74,80,82,85,[99][100][101][102][103][104][105][106] (Table 1). This interplay between gut microbiota and brain oxidative stress highlights the potential of the gut microbiome to modulate the brain redox status.…”

Section: Insight Into Associated Molecular Mechanismsmentioning

confidence: 62%

“…This is notably illustrated by an a posteriori increase in neuroinflammation, which was observed following menopause and the associated fall in oestrogen levels [109,110]. In models of (neuro)inflammatory diseases, e.g., direct administration of amyloid beta Aβ1-42 peptide [111], D-galactose [68,[80][81][82]99,104,105] or by other neurotoxins [111], oxidative stress, inflammation and mitochondrial dysfunction occur, usually in parallel to an abnormal gut ecosystem. This is of major importance as it validates the bidirectionality of the gut-brain axis, with induced neuro-disorders causing deleterious changes at the level of the microbiome.…”

Section: Insight Into Associated Molecular Mechanismsmentioning

confidence: 99%

Dietary (Poly)phenols and the Gut–Brain Axis in Ageing

Láng,

McArthur,

Lazar

et al. 2024

Nutrients

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As the population ages, the incidence of age-related neurodegenerative diseases is rapidly increasing, and novel approaches to mitigate this soaring prevalence are sorely needed. Recent studies have highlighted the importance of gut microbial homeostasis and its impact on brain functions, commonly referred to as the gut–brain axis, in maintaining overall health and wellbeing. Nonetheless, the mechanisms by which this system acts remains poorly defined. In this review, we will explore how (poly)phenols, a class of natural compounds found in many plant-based foods and beverages, can modulate the gut–brain axis, and thereby promote neural health. While evidence indicates a beneficial role of (poly)phenol consumption as part of a balanced diet, human studies are scarce and mechanistic insight is still lacking. In this regard, we make the case that dietary (poly)phenols should be further explored to establish their therapeutic efficacy on brain health through modulation of the gut–brain axis, with much greater emphasis on carefully designed human interventions.

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“…Taxifolin was reported to alleviate dextran sulfate sodium (DSS)-induced ulcerative colitis by acting on gut microbiome to produce butyric acid (Li et al, 2022). In addition, hesperetin-7-Oglucoside (Wu et al, 2021), rutin (Cheng et al, 2022), icariside I (Chen et al, 2021), quercetin (Liu et al, 2019a), epigallocatechin-3-gallate (Luo et al, 2022), epigallocatechin-3-gallate, and caffeine (Zhu et al, 2021) likewise showed similar effect. SCFAs maintain human health and may regulate some signaling pathways.…”

Section: Short-chain Fatty Acids (Scfas)mentioning

confidence: 98%

Dietary flavonoids and gut microbiota interaction: A focus on animal and human studies to maximize their health benefits

Yang,

Gao,

Farag

et al. 2023

Food Frontiers

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Flavonoids are phytochemicals that widely exist in plants, fruits, and vegetables and have a variety of activities. However, due to their complex structure, it is often rarely absorbed into the blood. Intestinal bacteria regarded as the third kind of human organ have attracted extensive attention in recent years. Complex structural flavonoids can be catabolized into low molecular weight phenolic acids under the action of intestinal bacteria and then absorbed into the blood, showing several protective effects on the body. In addition, the intake of flavonoids can also regulate the composition and function of intestinal flora. This paper comprehensively summarizes the interaction between flavonoids and intestinal flora, as well as the impact on human health, in order to provide some insights on how to combine intestinal microorganisms to select and ingest dietary polyphenols for future applications in medicine.

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Epigallocatechin-3-gallate alleviates galactose-induced aging impairment via gut–brain communication

Abstract: The study aimed to determine whether gut-brain communication could be modulated by Epigallocatechin-3-gallate (EGCG) in a mouse aging model that was established by daily injection of D-galactose (D-gal) for 10...

Cited by 9 publications

References 36 publications

Protective Effect of SGLT2 Inhibitor on D-Galactose-Induced Senescence in Mice and Its Mechanism

Protective Effect of SGLT2 Inhibitor on D-Galactose-Induced Senescence in Mice and Its Mechanism

Dietary (Poly)phenols and the Gut–Brain Axis in Ageing

Dietary flavonoids and gut microbiota interaction: A focus on animal and human studies to maximize their health benefits

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