Epigallocatechin-3-Gallate Ameliorates Experimental Autoimmune Encephalomyelitis by Altering Balance among CD4+ T-Cell Subsets

Wang, Junpeng; Ren, Zhihong; Xu, Yun; Xiao, Sheng; Meydani, Simin Nikbin; Wu, Dayong

doi:10.1016/j.ajpath.2011.09.007

Cited by 86 publications

(80 citation statements)

References 72 publications

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“…In this regard, epigallocatechin-3-gallate, a flavan-3-ol abundant in green tea, reduces the autoimmune response in the EAE through the inhibition of immune cell infiltration and the regulation of pro-and anti-autoimmune CD4(?) T cells (Wang et al 2012).…”

Section: Demyelination/remyelination and Nutrientsmentioning

confidence: 99%

Nutritional factors and aging in demyelinating diseases

Adamo

2013

Genes Nutr

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Demyelination is a pathological process characterized by the loss of myelin around axons. In the central nervous system, oligodendroglial damage and demyelination are common pathological features characterizing white matter and neurodegenerative disorders. Remyelination is a regenerative process by which myelin sheaths are restored to demyelinated axons, resolving functional deficits. This process is often deficient in demyelinating diseases such as multiple sclerosis (MS), and the reasons for the failure of repair mechanisms remain unclear. The characterization of these mechanisms and the factors involved in the proliferation, recruitment, and differentiation of oligodendroglial progenitor cells is key in designing strategies to improve remyelination in demyelinating disorders. First, a very dynamic combination of different molecules such as growth factors, cytokines, chemokines, and different signaling pathways is tightly regulated during the remyelination process. Second, factors unrelated to this pathology, i.e., age and genetic background, may impact disease progression either positively or negatively, and in particular, age-related remyelination failure has been proven to involve oligodendroglial cells aging and their intrinsic capacities among other factors. Third, nutrients may either help or hinder disease progression. Experimental evidence supports the anti-inflammatory role of omega-6 and omega-3 polyunsaturated fatty acids through the competitive inhibition of arachidonic acid, whose metabolites participate in inflammation, and the reduction in T cell proliferation. In turn, vitamin D intake and synthesis have been associated with lower MS incidence levels, while vitamin D-gene interactions might be involved in the pathogenesis of MS. Finally, dietary polyphenols have been reported to mitigate demyelination by modulating the immune response.

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Section: Demyelination/remyelination and Nutrientsmentioning

confidence: 99%

Nutritional factors and aging in demyelinating diseases

Adamo

2013

Genes Nutr

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“…These results strongly suggest a promising potential for using EGCG as a therapeutic agent in MS and possibly in other T-cell mediated autoimmune diseases [33].…”

Section: Real-time Pcrmentioning

confidence: 88%

“…Epigallocatechin-3-gallate attenuated symptoms and pathological features (leukocyte infiltration and demyelination) in the CNS and inhibited antigen specific T-cell proliferation and delayed type hypersensitivity of skin responses. These results demonstrate that EGCG may attenuate experimental autoimmune encephalomyelitis (EAE) autoimmune responses by inhibiting immune cell infiltration and modulating the balance among pro-and anti-autoimmune CD4 + T-cells [33]. It was shown that EGCG might be the most promising neuroprotective compound.…”

Section: Introductionmentioning

confidence: 86%

“…Administration of EGCG to EAE mice reduced brain inflammation, clinical symptoms, and neuronal damage. It was shown that treatment with EGCG reduced plasma levels of soluble intercellular adhesion molecule-1 and CD4 + T-cells expressing C-C chemokine receptor 6 (CCR6) in EAE mice [33]. It was also shown that EGCG treatment induced up-regulation of anti-apoptotic Bcl-2 and down-regulation of proapoptotic Bax in injured spinal tissues [14].…”

Section: Real-time Pcrmentioning

confidence: 93%

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Effects of green tea epigallocatechin-3-gallate on the proteolipid protein and oligodendrocyte transcription factor 1 messenger RNA gene expression in a mouse model of multiple sclerosis

Semnani¹,

Mashayekhi²,

Azarnia³

et al. 2017

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A b s t r a c t The cuprizone multiple sclerosis (MS) animal model is characteristic for toxic demyelination and represents a reversible demyelination and remyelination system. It has been shown that green tea epigallocatechin-3-gallate (EGCG) might be effective in improving the symptoms and pathological conditions associated with autoimmune inflammatory diseases in several animal models. In this study the effects of EGCG on proteolipid protein (PLP) and oligodendrocyte transcription factor 1 (Olig1) expression in the cerebral cortex of a murine model of cuprizone-induced demyelination was investigated. C57BL/6 mice were treated with cuprizone for six weeks in order to induce demyelination. Immediately after the cessation of cuprizone the animals were divided into 6 groups (n = 10 for each group). The first two groups were injected intraperitoneally (IP) with EGCG in the amount of 50 mg/kg/daily body weight for 2 and 4 weeks. The second two groups (SHAM) were injected IP with phosphate-buffered saline (PBS) for

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“…In this scenario, anti-inflammatory cytokines and regulatory T cells (Treg) may be important mediators, since they are competent suppressors of effector immune responses, mainly mediated by T helper (Th) cells (Elkord, 2008). Accordingly, some nutraceuticals have been shown to impact on Treg numbers or function both in vivo and in vitro (Issazadeh-Navikas, Teimer, & Bockermann, 2012;Wang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%