Epigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21–AMPK pathway in mice fed a high fat diet

Zhang, Yuanyuan; Yin, Ruili; Lang, Jianan; Fu, Ying; Yang, Longyan; Zhao, Dong

doi:10.1186/s13098-022-00823-y

Cited by 10 publications

(5 citation statements)

References 31 publications

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“…We hence suggest that curcumin intervention attenuate HFD induced FGF21 resistance [ 4 ]. Other dietary polyphenols including anthocyanin and resveratrol, as well as certain other nutraceuticals of plant origin were also shown to regulating hepatic FGF21 production, reported by our team and by others [ 42 , 46 ], [ 47 ], [ 48 ], [ 49 ], [ 50 ].…”

Section: Hepatic Fgf21 Expression Can Be Regulated By Dietary Polyphe...supporting

confidence: 58%

Fibroblast growth factor 21 and dietary interventions: what we know and what we need to know next

Jin

2022

Medical Review

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Dietary interventions include the change of dietary styles, such as fasting and dietary or nutrient restrictions; or the addition of plant-derived compounds (such as polyphenols known as curcumin, resveratrol, or anthocyanin, or other nutraceuticals) into the diet. During the past a few decades, large number of studies have demonstrated therapeutic activities of these dietary interventions on metabolic and other diseases in human subjects or various animal models. Mechanisms underlying those versatile therapeutic activities, however, remain largely unclear. Interestingly, recent studies have shown that fibroblast growth factor 21 (FGF21), a liver-derived hormone or hepatokine, mediates metabolic beneficial effects of certain dietary polyphenols as well as protein restriction. Here I have briefly summarized functions of FGF21, highlighted related dietary interventions, and presented literature discussions on role of FGF21 in mediating function of dietary polyphenol intervention and protein restriction. This is followed by presenting my perspective view, with the involvement of gut microbiota. It is anticipated that further breakthroughs in this field in the near future will facilitate conceptual merge of classical medicine and modern medicine.

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Section: Hepatic Fgf21 Expression Can Be Regulated By Dietary Polyphe...supporting

confidence: 58%

Fibroblast growth factor 21 and dietary interventions: what we know and what we need to know next

Jin

2022

Medical Review

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“…119 Moreover, EGCG also ameliorated hepatocyte injury in NAFLD by alleviating fibroblast growth factor-21 (FGF21) resistance and reducing oxidative stress through regulating the FGFR/AMPK pathway. 76 Similarly, TFs could reduce the production of ROS in steatotic hepatocytes. TFs also stimulated AMPK through the liver kinase B1 (LKB1) and ROS pathways, thereby inhibiting the activity of acetyl-CoA carboxylase.…”

Section: The Regulatory Mechanism Of Tea Active Compounds On Nafldmentioning

confidence: 99%

“…EGCG could alleviate endoplasmic reticulum stress and oxidative stress in NAFLD by regulating pathways such as TLR4/NF-κB and PI3K/AKT/FoxO1 . Moreover, EGCG also ameliorated hepatocyte injury in NAFLD by alleviating fibroblast growth factor-21 (FGF21) resistance and reducing oxidative stress through regulating the FGFR/AMPK pathway . Similarly, TFs could reduce the production of ROS in steatotic hepatocytes.…”

Section: The Regulatory Mechanism Of Tea Active Compounds On Nafldmentioning

confidence: 99%

Regulatory Effects and Molecular Mechanisms of Tea and Its Active Compounds on Nonalcoholic Fatty Liver Disease

Yang

Huang

et al. 2023

J. Agric. Food Chem.

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Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease, is a multifactorial disease resulting from the interaction between environment, genetic background, and metabolic stress. Most treatments for NAFLD include dietary intervention and exercise show limited efficacy due to the complex mechanisms involved in NAFLD. Meanwhile, drug therapy is accompanied by serious side effects. The development of high-efficiency natural supplements is a sustainable strategy for the prevention and treatment of NAFLD. As the second most consumed beverage, tea has health benefits that have been widely recognized. Nevertheless, the intervention of tea active compounds in NAFLD has received limited attention. Tea contains abundant bioactive compounds with potential effects on NAFLD, such as catechins, flavonoids, theanine, tea pigments, and tea polysaccharides. We reviewed the intrinsic and environmental factors and pathogenic mechanisms that affect the occurrence and development of NAFLD, and summarized the influences of exercise, drugs, diet, and tea drinking on NAFLD. On this basis, we further analyzed the potential effects and molecular regulatory mechanisms of tea active compounds on NAFLD and proposed future development directions. This review hopes to provide novel insights into the development and application of tea active compounds in the prevention and treatment of NAFLD.

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“…In addition, alleviating HFD-induced NAFLD in rats can be achieved by inhibiting the Akt/mTOR/ULK1 pathway to activate lipophagy in the liver ( 69 ). Furthermore, FGF21 has been found to be closely associated with the occurrence and progression of NAFLD and may serve as a key therapeutic target for NAFLD ( 70 , 71 ).…”

Section: Hfd Promotes the Development Of Metabolic Diseasesmentioning

confidence: 99%

Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders

Jia,

Chen,

et al. 2023

Front. Nutr.

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In the past two decades, the rapid increase in the incidence of metabolic diseases, including obesity, diabetes, dyslipidemia, non-alcoholic fatty liver disease, hypertension, and hyperuricemia, has been attributed to high-fat diets (HFD) and decreased physical activity levels. Although the phenotypes and pathologies of these metabolic diseases vary, patients with these diseases exhibit disease-specific alterations in the composition and function of their gut microbiota. Studies in germ-free mice have shown that both HFD and gut microbiota can promote the development of metabolic diseases, and HFD can disrupt the balance of gut microbiota. Therefore, investigating the interaction between gut microbiota and HFD in the pathogenesis of metabolic diseases is crucial for identifying novel therapeutic strategies for these diseases. This review takes HFD as the starting point, providing a detailed analysis of the pivotal role of HFD in the development of metabolic disorders. It comprehensively elucidates the impact of HFD on the balance of intestinal microbiota, analyzes the mechanisms underlying gut microbiota dysbiosis leading to metabolic disruptions, and explores the associated genetic factors. Finally, the potential of targeting the gut microbiota as a means to address metabolic disturbances induced by HFD is discussed. In summary, this review offers theoretical support and proposes new research avenues for investigating the role of nutrition-related factors in the pathogenesis of metabolic disorders in the organism.

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Epigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21–AMPK pathway in mice fed a high fat diet

Cited by 10 publications

References 31 publications

Fibroblast growth factor 21 and dietary interventions: what we know and what we need to know next

Fibroblast growth factor 21 and dietary interventions: what we know and what we need to know next

Regulatory Effects and Molecular Mechanisms of Tea and Its Active Compounds on Nonalcoholic Fatty Liver Disease

Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders

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