Epigallocatechin-3-gallate (EGCG) protects the oocytes from methyl parathion-induced cytoplasmic deformities by suppressing oxidative and endoplasmic reticulum stress

Hegde, Shruti; Poojary, Keerthana Karunakar; Rasquinha, Rhea; Crasta, Daphne Norma; Gopalan, Divya; Mutalik, Srinivas; Siddiqui, Sazada; Adiga, Satish Kumar; Kalthur, Guruprasad

doi:10.1016/j.pestbp.2020.104588

Cited by 13 publications

(6 citation statements)

References 76 publications

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“…It consists of three branches, each of which transduces ER stress signals to the cytoplasm via transmembrane regulators (IRE1, PERK, or ATF6), thereby activating different downstream signaling pathways [26]. EGCG has beneficial effects in attenuating the toxic effects of methyl parathion on oocytes, and these effects appear to be associated with the downregulation of XBP1 downstream of IRE1 [17]. Our study showed that RNAi targeting ire-1 abolished the inhibitory effect of EGCG on Cd-induced ER stress in the nematode head (Figure 5A,B), suggesting that the beneficial effect of EGCG is associated with IRE-1.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown to have ameliorative effects on a wide range of chronic diseases such as cardiovascular disease, cancer, and neurodegenerative diseases [12]. It can reduce the toxicity caused by pesticides such as paraquat [15], dichlorodiphenyltrichloroethane (DDT) [16], and methyl parathion [17]. It has been shown to increase the viability of HL-7702 and PC12 cells under Cd exposure and ameliorate Cd-induced renal injury in adult male Wistar albino rats [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Epigallocatechin-3-Gallate Reduces Cd-Induced Developmental Toxicity of Bodysize in Caenorhabditis elegans via the PEK-1/eIF-2α/ATF-4 Pathway

Wang,

Chen,

2023

Molecules

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Cadmium (Cd), a harmful heavy metal that has no biological purpose, can harm healthy fetal and child development. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in tea, has been shown to increase cell viability under Cd exposure and ameliorate Cd-induced kidney injury in adult male rats. Using the Caenorhabditis elegans (C. elegans) model, we demonstrated that EGCG mitigated Cd-induced body size developmental toxicity through a mechanism that did not involve chelation with EGCG and was not associated with Cd accumulation and efflux. Our research indicated that the beneficial effects of EGCG on Cd-induced body size developmental toxicity were associated with the mitigation of endoplasmic reticulum stress. Furthermore, our observations indicate that EGCG reduced Cd-induced developmental toxicity in C. elegans via the PEK-1/eIF-2α/ATF-4 pathway. Our results provide important evidence for the potential benefits of consuming tea as a detoxification agent.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epigallocatechin-3-Gallate Reduces Cd-Induced Developmental Toxicity of Bodysize in Caenorhabditis elegans via the PEK-1/eIF-2α/ATF-4 Pathway

Wang,

Chen,

2023

Molecules

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“…ATP is necessary for proper spindle alignment, and glutathione is an important antioxidant found at very high concentrations in oocytes. This same group later found that methyl parathion led to aberrant mitochondria distribution patterns and increased indicators of oxidative and endoplasmic reticulum stress, effects that were rescued by cotreatment with the free radical scavenger, epigallocatechin-3gallate [97].…”

Section: Pesticidesmentioning

confidence: 92%

Toxicant effects on mammalian oocyte mitochondria†

Malott

Luderer

2021

Biology of Reproduction

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Oocyte mitochondria are unique organelles that establish a founder population in primordial germ cells (PGCs). As the oocyte matures in the postnatal mammalian ovary during folliculogenesis it increases exponentially in volume, and the oocyte mitochondria population proliferates to about 100,000 mitochondria per healthy, mature murine oocyte. The health of the mature oocyte and subsequent embryo is highly dependent on the oocyte mitochondria. Mitochondria are especially sensitive to toxic insults, as they are a main source of reactive oxygen species (ROS), they contain their own DNA (mtDNA) that is unprotected by histone proteins, they contain the electron transport chain that uses electron donors, including oxygen, to generate ATP, and they are important sensors for overall cellular stress. Here we review the effects that toxic insults including chemotherapeutics, toxic metals, plasticizers, pesticides, polycyclic aromatic hydrocarbons (PAHs), and ionizing radiation can have on oocyte mitochondria. This is very clearly a burgeoning field, as our understanding of oocyte mitochondria and metabolism is still relatively new, and we contend much more research is needed to understand the detrimental impacts of exposure to toxicants on oocyte mitochondria. Developing this field further can benefit our understanding of assisted reproductive technologies and the developmental origins of health and disease (DOHaD).

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“… S/N Flavonoids Organs/animal Target Disease condition References 1 Acacetin Liver ATF6 and CHOP Non-alcoholic fatty liver disease Jiang et al (2023) 2 Apigenin Liver and visceral fats p-PERK, GRP78, p-eIF2a, and CHOP Obesity Wu et al (2021) 3 Baicalein Spinal cord GRP78, ATF4, CHOP, and CASP12 Ischemia-reperfusion Injury Wu et al (2020) 5 EGCG Brain GRP78, CHOP, cleaved-caspase-12 and caspase-3. Alzheimer's disease Du et al (2018) Ovaries GRP78 and XBP1 Reproductive system disorder Hegde et al (2020) 6 Fisetin Liver ROS, GRP78 and CHOP NAFLD Dai et al (2022) Heart PERK, eIF2α, IRE1, XBP1 and CHOP Cardiomyopathy Ge et al (2019) 8 Hyperoside Heart BiP, CHOP and Nrf2 Cardiac ischemia-reperfusion injury Hou et al (2016) 9 Icariin Spinal cord ATF6, IRE1α, GRP78, XBP1 and eIF2α Neuronal apoptosis ...…”

Section: Flavonoidsmentioning

confidence: 99%

Endoplasmic reticulum stress in pancreatic β-cell dysfunction: The potential therapeutic role of dietary flavonoids

Mbara,

Fotsing,

Ndinteh

et al. 2024

Current Research in Pharmacology and Drug Discovery

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Epigallocatechin-3-gallate (EGCG) protects the oocytes from methyl parathion-induced cytoplasmic deformities by suppressing oxidative and endoplasmic reticulum stress

Cited by 13 publications

References 76 publications

Epigallocatechin-3-Gallate Reduces Cd-Induced Developmental Toxicity of Bodysize in Caenorhabditis elegans via the PEK-1/eIF-2α/ATF-4 Pathway

Epigallocatechin-3-Gallate Reduces Cd-Induced Developmental Toxicity of Bodysize in Caenorhabditis elegans via the PEK-1/eIF-2α/ATF-4 Pathway

Toxicant effects on mammalian oocyte mitochondria†

Endoplasmic reticulum stress in pancreatic β-cell dysfunction: The potential therapeutic role of dietary flavonoids

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