Epigallocatechin-3-Gallate Inhibits Oxidative Stress Through the Keap1/Nrf2 Signaling Pathway to Improve Alzheimer Disease

Tang, Shi; Zhang, Yong; Botchway, Benson O. A.; Wang, Xichen; Huang, Min; Liu, Xuehong

doi:10.1007/s12035-024-04498-6

Mol Neurobiol

2024

DOI: 10.1007/s12035-024-04498-6

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Epigallocatechin-3-Gallate Inhibits Oxidative Stress Through the Keap1/Nrf2 Signaling Pathway to Improve Alzheimer Disease

Shi Tang,

Yong Zhang,

Benson O. A. Botchway

et al.

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2024

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Cited by 2 publications

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Health Benefits of Epigallocatechin Gallate and Forskolin with a Special Emphasis on Glaucoma and Other Retinal Diseases

Rusciano

2024

Medicina

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This review highlights the therapeutic potential of epigallocatechin gallate (EGCG) and forskolin in managing retinal diseases, with a focus on glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy. EGCG, a potent polyphenol from green tea, exhibits significant antioxidant, anti-inflammatory, and neuroprotective effects, making it a promising candidate for reducing oxidative stress and inflammation in ocular tissues. Forskolin, a diterpene from Coleus forskohlii, increases cyclic AMP (cAMP) levels, which helps lower intraocular pressure (IOP) and provides neuroprotection. Both compounds target critical pathways involved in retinal disease progression, including oxidative stress, mitochondrial dysfunction, and inflammation, offering complementary therapeutic benefits. This review consolidates preclinical and clinical studies, highlighting the potential of EGCG and forskolin as adjunctive or alternative treatments for retinal diseases. Future research should explore the synergistic effects of these compounds, particularly in combination therapies aimed at addressing multiple pathogenic mechanisms in retinal health.

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Health Benefits of Epigallocatechin Gallate and Forskolin with a Special Emphasis on Glaucoma and Other Retinal Diseases

Rusciano

2024

Medicina

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Oxidative Stress in the Pathogenesis of Neurodegenerative Diseases

Jurcau,

Diaconu

2024

Stresses

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Neurodegenerative diseases are devastating conditions with a rising incidence and prevalence due to the aging of the population for which we currently do not have efficient therapies. Despite compelling evidence provided by basic research on the involvement of oxidative stress in their pathogenesis, most trials with antioxidants have failed. The reasons may relate to the low bioavailability of the used compounds or to starting therapy late, when the pathogenic cascades have already induced irreversible damage. The current review discusses the sources of oxidative stress in the central nervous system, the involvement of reactive oxygen species in the pathogenesis of Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, and the importance of further research on improved delivery methods of antioxidants as well as the search for biomarkers that could help in early diagnosis in the hope of finding more efficient therapies for these diseases.

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Epigallocatechin-3-Gallate Inhibits Oxidative Stress Through the Keap1/Nrf2 Signaling Pathway to Improve Alzheimer Disease

Cited by 2 publications

References 118 publications

Health Benefits of Epigallocatechin Gallate and Forskolin with a Special Emphasis on Glaucoma and Other Retinal Diseases

Health Benefits of Epigallocatechin Gallate and Forskolin with a Special Emphasis on Glaucoma and Other Retinal Diseases

Oxidative Stress in the Pathogenesis of Neurodegenerative Diseases

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