Epigallocatechin-3-gallate inhibits VCAM-1 expression and apoptosis induction associated with LC3 expressions in TNFα-stimulated human endothelial cells

Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3

“…Zhou et al 76 demonstrated that EGCG stimulates autophagy in HepG2 cells and in mice on a high-fat diet, 76 while further evidence has proved that EGCG exhibited an antiautophagic effect in Hep3B cells, retinal pigment epithelial cells, skeletal muscle cells, etc. 77 – 82 Interestingly, in our mouse model of AIH with EGCG pretreatment, the change in gene and protein expression levels of Bcl-2, Caspase-9, and Caspase-3, as well as Beclin-1, P62, and LC3-II, suggested that as expected, EGCG had a protective effect in liver injury by inhibiting apoptosis and autophagy.…”

l‐Theanine inhibits proinflammatory PKC/ERK/ICAM‐1/IL‐33 signaling, apoptosis, and autophagy formation in substance P‐induced hyperactive bladder in rats

“…Lee et al have reported that high‐fat diet‐induced abnormal mitochondrial β‐oxidation was moderated by the consumption of caffeine‐ and theanine‐enriched green tea. l ‐Theanine can inhibit TNF‐α‐induced monocytic cell adhesion, apoptosis, and autophagy in the human endothelial cells by affecting LC3 expression‐related processes . In the results of Figure , SP evoked ROS formation and subsequently resulted in LC3 II‐mediated autophagic cell death and Caspase 3/PARP‐mediated apoptotic cell death suggesting these two types of programmed cell death involving in hyperactive bladder.…”

“…L-Theanine can inhibit TNF-a-induced monocytic cell adhesion, apoptosis, and autophagy in the human endothelial cells by affecting LC3 expression-related processes. 39 In the results of Figure 5, SP evoked ROS formation and subsequently resulted in LC3 IImediated autophagic cell death and Caspase 3/PARP-mediated apoptotic cell death suggesting these two types of programmed cell death involving in hyperactive bladder. The use of theanine can ameliorate SP-induced hyperactive bladder and inhibit autophagy and apoptosis in the damaged bladders possibly through antioxidant and anti-inflammation.…”

Effects of catechins and caffeine on the development of atherosclerosis in mice

“…Moreover, EGCG suppressed VCAM-1 expression in human vascular endothelial cells stimulated by TNF-α in vitro. 27) Therefore, it was considered that the expression of these adhesion molecules is decreased by catechins and caffeine. However, there was no change in mRNA expression of VCAM-1 in aorta from catechins and catechins + caffeine groups.…”