2017
DOI: 10.1016/j.pharep.2017.04.008
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Epigallocatechin-3-gallate promotes apoptosis in human breast cancer T47D cells through down-regulation of PI3K/AKT and Telomerase

Abstract: This study suggests that EGCG may be a useful adjuvant therapeutic agent for the treatment of breast cancer.

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Cited by 98 publications
(61 citation statements)
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References 28 publications
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“…PTEN is a significant negative regulator of the PI3K/Akt/mTOR pathway, which is involved in many cellular actions like proliferation, migration and differentiation. Also, this pathway is involved in cancer cell survival, proliferation and progression [33]. However, RA did not affect the expression level of PTEN in our study.…”
Section: Resultscontrasting
confidence: 60%
“…PTEN is a significant negative regulator of the PI3K/Akt/mTOR pathway, which is involved in many cellular actions like proliferation, migration and differentiation. Also, this pathway is involved in cancer cell survival, proliferation and progression [33]. However, RA did not affect the expression level of PTEN in our study.…”
Section: Resultscontrasting
confidence: 60%
“…19 EGCG also reported to initiate the mitochondrial pathway of apoptosis in different cancer cells [47][48][49] as well as in HeLa cells. 19 EGCG also reported to initiate the mitochondrial pathway of apoptosis in different cancer cells [47][48][49] as well as in HeLa cells.…”
Section: Discussionmentioning
confidence: 95%
“…After 25 min incubation at 37 °C in the dark, cytospin slides were prepared and stained with Giemsa. Differentiated cells were recognized by their intracellular reduced dark blue formazan granules (300 cells were scored for the presence of the granules, Moradzadeh, Hosseini, Erfanian, & Rezaei, ; Moradzadeh et al, ).…”
Section: Methodsmentioning
confidence: 99%