(-)-Epigallocatechin-3-gallate provides neuroprotection via AMPK activation against traumatic brain injury in a mouse model

Wu, Yinyin; Cui, Jing

doi:10.1007/s00210-020-01841-1

Cited by 23 publications

(16 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the biological activities of green tea extracts are linked to this composition [79]. Several experimental studies have reported that EGCG causes neuroprotection against neurodegenerative diseases [80], brain injury [81], SCI [82], and peripheral nerve damage [83] through its antiapoptotic, anti-inflammatory, and antioxidant properties [84]. The presence of hydroxyl groups in rings B and D of the catechins makes them bind free radicals [85].…”

Section: Polyphenols Target Upstream Mediators Of Oxidative Stress After Scimentioning

confidence: 99%

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Fakhri

Abbaszadeh

Moradi

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Despite the progression in targeting the complex pathophysiological mechanisms of neurodegenerative diseases (NDDs) and spinal cord injury (SCI), there is a lack of effective treatments. Moreover, conventional therapies suffer from associated side effects and low efficacy, raising the need for finding potential alternative therapies. In this regard, a comprehensive review was done regarding revealing the main neurological dysregulated pathways and providing alternative therapeutic agents following SCI. From the mechanistic point, oxidative stress and inflammatory pathways are major upstream orchestras of cross-linked dysregulated pathways (e.g., apoptosis, autophagy, and extrinsic mechanisms) following SCI. It urges the need for developing multitarget therapies against SCI complications. Polyphenols, as plant-derived secondary metabolites, have the potential of being introduced as alternative therapeutic agents to pave the way for treating SCI. Such secondary metabolites presented modulatory effects on neuronal oxidative stress, neuroinflammatory, and extrinsic axonal dysregulated pathways in the onset and progression of SCI. In the present review, the potential role of phenolic compounds as critical phytochemicals has also been revealed in regulating upstream dysregulated oxidative stress/inflammatory signaling mediators and extrinsic mechanisms of axonal regeneration after SCI in preclinical and clinical studies. Additionally, the coadministration of polyphenols and stem cells has shown a promising strategy for improving post-SCI complications.

show abstract

Section: Polyphenols Target Upstream Mediators Of Oxidative Stress After Scimentioning

confidence: 99%

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Fakhri

Abbaszadeh

Moradi

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…This composition is related to the biological functions of green tea extracts [ 56 ]. EGCG's anti-apoptotic, anti-inflammatory, and antioxidant actions have been demonstrated to prevent against NDDs [ 57 ], brain injury [ 58 ], SCI [ 59 ], and peripheral nerve damage [ 60 ] in many experiments conducted. The hydroxyl groups in the catechins ring B and D cause them to interact with free radicals [ 61 ].…”

Section: Polyphenols In Spinal Cord Injurymentioning

confidence: 99%

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

Islam

Bepary

Nafady

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

A spinal cord injury (SCI) occurs when the spinal cord is deteriorated or traumatized, leading to motor and sensory functions lost even totally or partially. An imbalance within the generation of reactive oxygen species and antioxidant defense levels results in oxidative stress (OS) and neuroinflammation. After SCI, OS and occurring pathways of inflammations are significant strenuous drivers of cross-linked dysregulated pathways. It emphasizes the significance of multitarget therapy in combating SCI consequences. Polyphenols, which are secondary metabolites originating from plants, have the promise to be used as alternative therapeutic agents to treat SCI. Secondary metabolites have activity on neuroinflammatory, neuronal OS, and extrinsic axonal dysregulated pathways during the early stages of SCI. Experimental and clinical investigations have noted the possible importance of phenolic compounds as important phytochemicals in moderating upstream dysregulated OS/inflammatory signaling mediators and axonal regeneration’s extrinsic pathways after the SCI probable significance of phenolic compounds as important phytochemicals in mediating upstream dysregulated OS/inflammatory signaling mediators. Furthermore, combining polyphenols could be a way to lessen the effects of SCI.

show abstract

“…Also, Romani et al (1999) reported that MC contained phenolic compounds such as catechin and myricetin-derived compounds as major constituents [20]. In previous studies, these compounds have been reported to have ameliorative effects in different traumatic brain injury models [45][46][47][48][49]. In addition, it was shown that catechin-derived compounds had the protective effects on the functions of brain in mice fed with HFD [50,51].…”

Section: Discussionmentioning

confidence: 97%

Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

Özbeyli¹,

YARIMBAŞ²,

Ertaş³

et al. 2020

JRP

View full text Add to dashboard Cite

Obesity causes cognitive weakening and increases the risk of neurodegenerative diseases. Myrtus communis extract (MC) has anti-inflammatory and antioxidant properties. In this study, it is aimed to investigate the effects of Myrtus communis on oxidative brain damage caused by a high-fat diet (HFD), using behavioral and biochemical parameters. Twenty-four Wistar albino rats (200-250 g) were divided into three groups. The control group (C) received a standard diet, while HFD groups were received HFD for 16 weeks. MC (100 mg/kg, oral) was given to the HFD + MC group for the last 4 weeks. At the end of the study, the novel object recognition test (NORT) was performed and the hippocampus and blood samples were collected. Acetylcholinesterase (AChE) and Na + /K +-ATPase activities, malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and reduced glutathione (GSH) levels were measured in the hippocampal samples and cholesterol levels were analyzed in sera. Findings have shown that NORT performance of the HFD group was reduced, while administration of MC prevents this reduction and in parallel, increased AChE and decreased Na⁺ /K⁺-ATPase activities were ameliorated by administration of MC. Increased MDA and 8-OHdG levels observed in the HFD group, were decreased in the MC treated HFD group. Our results point out that MC has ameliorative effects on hippocampal oxidative stress and cognitive impairment in high fat nutritioninduced obesity.

show abstract

(-)-Epigallocatechin-3-gallate provides neuroprotection via AMPK activation against traumatic brain injury in a mouse model

Cited by 23 publications

References 48 publications

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

Contact Info

Product

Resources

About