Epigallocatechin-3-Gallate Suppresses IGF-I-Induced Lipogenesis and Cytokine Expression in SZ95 Sebocytes

Im, Myung; Kim, Soo Y.; Sohn, Kyung Cheol; Choi, Dae Kyoung; Lee, Young; Seo, Young‐Joon; Kim, Chang Deok; Hwang, Yul Lye; Zouboulis, Christos C.; Lee, Jeung H.

doi:10.1038/jid.2012.202

Cited by 50 publications

(37 citation statements)

References 38 publications

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“…Furthermore, IGF1 stimulates proliferation in rat preputial sebocytes, which aligns with the known stimulatory role of the PI3K/AKT/mTOR pathway in proliferation . However, there are conflicting data regarding the ability of IGF1 to stimulate proliferation in SZ95 cells . IGF1 and insulin also promote expression of proinflammatory cytokines and Toll‐receptors in SZ95 cells, indicating a possible role of IIS in the inflammatory component of acne.…”

Section: Factors Controlling Sebaceous Gland Homeostasissupporting

confidence: 66%

“…In vitro , IGF1 stimulates lipid synthesis in SZ95 and SEB‐1 sebocytes . Promotion of lipogenesis is induced via phosphoinositol‐3‐kinase (PI3K)/AKT‐mediated activation of the transcription factor SREBP‐1, an activator of genes involved in lipid metabolism (Appendix S1; see Supporting Information) .…”

Section: Factors Controlling Sebaceous Gland Homeostasismentioning

confidence: 99%

“…190 In vitro, IGF1 stimulates lipid synthesis in SZ95 and SEB-1 sebocytes. [191][192][193][194][195][196] Promotion of lipogenesis is induced via phosphoinositol-3-kinase (PI3K)/AKT-mediated activation of the transcription factor SREBP-1, an activator of genes involved in lipid metabolism (Appendix S1; see Supporting Information). 192,197 Insulin also promotes lipid production and proliferation in SZ95 cells through PI3K/AKT and mammalian target of rapamycin (mTOR) signalling.…”

Section: Erbb Family Receptor Signallingmentioning

confidence: 99%

“…196 However, there are conflicting data regarding the ability of IGF1 to stimulate proliferation in SZ95 cells. 194,195 IGF1 and insulin also promote expression of proinflammatory cytokines and Toll-receptors in SZ95 cells, 118,194,195 indicating a possible role of IIS in the inflammatory component of acne.…”

Section: Erbb Family Receptor Signallingmentioning

confidence: 99%

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Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

et al. 2019

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Summary Background Sebaceous glands (SGs) are appendages of mammalian skin that produce a mixture of lipids known as sebum. Acne vulgaris is an exceptionally common skin condition, characterized by elevated sebum production, altered sebum composition, and the formation of infundibular cysts, called comedones. Comedo‐associated SGs are atrophic, suggesting that comedo formation involves abnormal differentiation of progenitor cells that generate the SG and infundibulum: the ‘comedo switch’. Understanding the biological processes that govern SG homeostasis promises to highlight potential aetiological mechanisms underlying acne and other SG‐associated skin disorders. Results In this review, we discuss the clinical data, genetic mouse models and in vitro research that have highlighted major hormones, paracrine factors, transcription factors and signalling pathways that control SG homeostasis. These include, but are not limited to androgens, progestogens and oestrogens; retinoids; receptor tyrosine kinases such as ErbB family receptors, fibroblast growth factor receptor 2 and insulin/insulin‐like growth factor 1 receptors; peroxisome proliferator‐activated receptor γ; aryl hydrocarbon receptor; and the Wnt signalling pathway. Where possible, the cellular and molecular mechanisms by which these regulatory factors control SG biology are indicated, along with considerations as to how they might contribute to acne pathogenesis. Conclusions Future research should seek to establish the relative importance, and causative relationships, of altered sebum production, sebum composition, inflammation and abnormal differentiation of sebaceous progenitors to the process of comedo formation in acne. Such an understanding will allow for therapeutic targeting of regulatory factors that control SG homeostasis, with the aim of treating acne.

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Section: Factors Controlling Sebaceous Gland Homeostasissupporting

confidence: 66%

Section: Factors Controlling Sebaceous Gland Homeostasismentioning

confidence: 99%

Section: Erbb Family Receptor Signallingmentioning

confidence: 99%

Section: Erbb Family Receptor Signallingmentioning

confidence: 99%

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Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

et al. 2019

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“…The green tea-derived plant sterols have shown a therapeutic role in the treatment of acne vulgaris [22]. Im et al, 2012 provided experimental evidence that EGCG treatment of insulin growth factor (IGF-1) stimulated SZ95 sebocytes decreased mTOR phosphorylation and thus mTORC1 activity [23]. Additionally, Van Aller et al, 2011 [24] provided evidence that EGCG is an ATP-competitive inhibitor of both PI3K and mTOR.…”

Section: Introductionmentioning

confidence: 99%

Green Tea and Other Tea Polyphenols: Effects on Sebum Production and Acne Vulgaris

2016

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Polyphenols are antioxidant molecules found in many foods including nuts, fruits, vegetables, chocolate, wine, and tea. Polyphenols have antimicrobial, anti-inflammatory, and antineoplastic properties. Recent studies suggest that tea polyphenols may be used for reducing sebum production in the skin and for treatment of acne vulgaris. This review examines the evidence for use of topically and orally ingested tea polyphenols against sebum production and for acne treatment and prevention. The PubMed database was searched for studies on tea polyphenols, sebum secretion, and acne vulgaris. Of the 59 studies found, eight met the inclusion criteria. Two studies evaluated tea polyphenol effects on sebum production; six studies examined tea polyphenol effects on acne vulgaris. Seven studies evaluated topical tea polyphenols; one study examined systemic tea polyphenols. None of the studies evaluated both topical and systemic tea polyphenols. Tea polyphenol sources included green tea (six studies) and tea, type not specified (two studies). Overall, there is some evidence that tea polyphenols in topical formulation may be beneficial in reducing sebum secretion and in treatment of acne. Research studies of high quality and with large sample sizes are needed to assess the efficacy of tea polyphenols in topical and oral prevention of acne vulgaris and lipid synthesis by the sebaceous glands.

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The effects of green tea on acne vulgaris: A systematic review and meta‐analysis of randomized clinical trials

Kim

Park

Kim

et al. 2020

Phytotherapy Research

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Green tea extract (GTE) has been studied for the treatment of acne based on its anti‐inflammatory/antioxidant properties. This systematic review and meta‐analysis aimed to examine the effects of GTE on acne. Electronic databases, including PubMed, Embase, and the Cochrane Library were systematically searched up to August 2019. The effect size of acne lesion counts is presented as mean differences and 95% confidence intervals (CIs). Five randomized‐controlled studies were included in the meta‐analysis (N; experimental = 125, control = 122). GTE significantly reduced the number of inflammatory lesions (−9.38; 95% CI: −14.13 to −4.63). In subgroup analysis, topical GTE application significantly reduced the inflammatory lesion counts (−11.39; 95% CI: −15.91 to −6.86) whereas oral GTE intake showed minimal effect (−1.40; 95% CI: −2.50 to −0.30). Although GTE did not significantly reduce the number of non‐inflammatory lesions (−21.65; 95% CI: −47.52 to 4.22), when stratified by the route of admission, non‐inflammatory acne lesions were significantly reduced by topical GTE application (−32.44; 95% CI: −39.27 to −25.62) but not with oral GTE administration (0.20; 95% CI: 0.00 to 0.40). This systematic review and meta‐analysis suggest that topical GTE application is beneficial for the treatment of acne without causing significant adverse events while oral GTE intake has limited effects. Further high‐quality clinical trials are warranted.

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Epigallocatechin-3-Gallate Suppresses IGF-I-Induced Lipogenesis and Cytokine Expression in SZ95 Sebocytes

Cited by 50 publications

References 38 publications

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

Green Tea and Other Tea Polyphenols: Effects on Sebum Production and Acne Vulgaris

The effects of green tea on acne vulgaris: A systematic review and meta‐analysis of randomized clinical trials

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