Epigallocatechin gallate-derived carbonized polymer dots: A multifunctional scavenger targeting Alzheimer's β-amyloid plaques

Lin, Xiaoding; Liu, Wei; Dong, Xiaoyan; Sun, Yan

doi:10.1016/j.actbio.2022.11.063

Cited by 29 publications

(12 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, by comparing the fluorescence of PS-CPDs with previously reported nitrogen-doped carbonized polymer dots (CPDs) (Figure S1f), it concluded that photosensitizers have been successfully doped into CPDs. Notably, the fluorescence of the photosensitizer precursors existed in the synthesized PS-CPDs due to the retention of fluorescent groups of the photosensitizers, which provided the basis for the following photooxygenation assays. Then, the UV–vis absorption of PS-CPDs was recorded in Figures b, S2a and S2b.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, compared with the previously reported bPEI@CDs (500 μg/mL, white light, 2 days) 54 and Apta@ CDs (25 μg/mL, 10 mW/cm 2 , 2 h), 46 MB-CPDs could effectively inhibit Aβ aggregation at a low concentration (0.5 μg/mL) with short light irradiation time (80 mW/cm 2 , 10 min). Of note, compared with other classical CDs, 45 photoactivated MB-CPDs also exhibited more potent inhibitory capability at a very low concentration of 0.5 μg/mL. AFM was then used to further observe the morphology of the Aβ 40 aggregates.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Methylene Blue-Doped Carbonized Polymer Dots: A Potent Photooxygenation Scavenger Targeting Alzheimer’s β-Amyloid

Lin,

Zhang,

Liu

et al. 2023

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

The abnormal aggregation of β-amyloid protein (Aβ) is one of the main pathological hallmarks of Alzheimer's disease (AD), and thus development of potent scavengers targeting Aβ is considered an effective strategy for AD treatment. Herein, photosensitizer-doped carbonized polymer dots (PS-CPDs) were synthesized by a one-step hydrothermal method using photosensitizer (PS) and o-phenylenediamine (oPD) as precursors, and furtherly applied to inhibit Aβ aggregation via photooxygenation. The inhibition efficiency of such PS-CPDs can be adjusted by varying the type of photosensitizer, and among them, methylene blue-doped carbonized polymer dots (MB-CPDs) showed the strongest photooxygenation inhibition capability. The results demonstrated that under 650 nm NIR light irradiation, MB-CPDs (2 μg/mL) produced reactive oxygen species (ROS) to efficiently inhibit Aβ fibrillization and disaggregate mature Aβ fibrils and increased the cultured cell viability from 50% to 83%. In vivo studies confirmed that MB-CPDs extended the lifespan of AD nematodes by 4 days. Notably, the inhibitory capability of MB-CPDs is much stronger than that of MB and previously reported carbonized polymer dots. This work indicated that potent photooxygenation carbon dots can be obtained by using a photosensitizer as one of the precursors, and the results have provided new insights into the design of potent photooxygenation carbon nanomaterials targeting Aβ in AD treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Methylene Blue-Doped Carbonized Polymer Dots: A Potent Photooxygenation Scavenger Targeting Alzheimer’s β-Amyloid

Lin,

Zhang,

Liu

et al. 2023

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

show abstract

“…[230] The therapeutical effect of EGCG-derived carbonized polymer dots (E-CPDs) (Table 1), which specifically target A𝛽 fibrillation, has also been observed in Caenorhabditis elegans CL2006. [231] And to improve the limitation of usual carbon CDs appliance in the clearance of A𝛽 in vivo, Chaoren Yan et al proposed a yellow fluorescent carbon dots assembled with photosensitizers (chlorine e6, a photosensitizer generating 1 O 2 under NIR irradiation). The yCDs-Ce6 (Table 1) equipped with photothermal characteristics could inhibit and eliminate A𝛽1-42 in the deeper brain areas in vivo under an 808 nm laser.…”

Section: D Carbon-based Nanomaterialsmentioning

confidence: 99%

Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials

Huang,

Liao,

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease that constitutes the third most common cause of death among elderly individuals. AD patients suffer from behavioral problems regularly, like memory loss, thinking deficits, and cognitive disorders. Currently, the incidence rate of AD has been on the rise worldwide. Therefore, it is imperative to develop effective strategies for the treatment and prevention of AD. The inherent characteristics of low‐dimensional nanomaterials, primarily their smaller size and surface structure, make them well‐suited for fulfilling the essential requirements of therapeutic drug design. Consequently, these nanomaterials offer a highly appealing and alternative approach to treating AD. Here, the low‐dimensional nanomaterials used in the treatment of AD to provide new ideas, methods, and comprehensive perspectives for the management of AD are reviewed. This review will advance the comprehensive understanding of the potential of low‐dimensional nanomaterials in the field of neuro medicine, which also will have a positive impact on future research.

show abstract

“…As reported previously, diverse Ab scavengers, including small molecules, 12,13 proteins, 14 nanomaterials, 15,16 and peptides, 17,18 have been designed to modulate the on-pathway fibrillization. When compared with others, the scavengers based on nanomaterials display outstanding advantages, such as easy functionalization, desirable biodegradability, and high biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Design of aggregation-induced emission-active fluorogen-based nanoparticles for imaging and scavenging Alzheimer's β-amyloid by photo-oxygenation

Liu,

Sun

et al. 2023

J. Mater. Chem. B

Self Cite

View full text Add to dashboard Cite

show abstract

Epigallocatechin gallate-derived carbonized polymer dots: A multifunctional scavenger targeting Alzheimer's β-amyloid plaques

Cited by 29 publications

References 67 publications

Methylene Blue-Doped Carbonized Polymer Dots: A Potent Photooxygenation Scavenger Targeting Alzheimer’s β-Amyloid

Methylene Blue-Doped Carbonized Polymer Dots: A Potent Photooxygenation Scavenger Targeting Alzheimer’s β-Amyloid

Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials

Design of aggregation-induced emission-active fluorogen-based nanoparticles for imaging and scavenging Alzheimer's β-amyloid by photo-oxygenation

Contact Info

Product

Resources

About