Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells

Tsang, Wing Pui; Kwok, Tim Tak

doi:10.1016/j.jnutbio.2008.12.003

Cited by 301 publications

(201 citation statements)

References 33 publications

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“…In addition, Zhang et al (38) reported that curcumin downregulates miR-186 and therefore induces cell apoptosis in lung cancer cells. The main component of tea catechins, EGCG, was found to upregulate miR-16 and downregulate its targeted gene Bcl-2 to induce apoptosis in human cancer cells (23). This previous study also demonstrated that EGCG modified the expression of various miRs in human hepatocellular carcinoma HepG2 cells.…”

Section: Discussionmentioning

confidence: 70%

“…The inhibitory effects of tea catechins against experimental carcinogenesis have also been demonstrated in many animal models (19)(20)(21). In recent years, it has been reported that tea catechins induce the modification of the expression profile of miRs and mediate the apoptotic effect in human cancer cells (22,23). Furthermore, let-7 is known as a tumor suppressor in lung cancer cells or animal models by repressing cell proliferation (10,(24)(25)(26) and its expression profile may be altered by various agents (23,27,28).…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, it has been reported that tea catechins induce the modification of the expression profile of miRs and mediate the apoptotic effect in human cancer cells (22,23). Furthermore, let-7 is known as a tumor suppressor in lung cancer cells or animal models by repressing cell proliferation (10,(24)(25)(26) and its expression profile may be altered by various agents (23,27,28). However, the effect and mechanism of tea catechins on let-7 expression in human lung cancer remain unknown.…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of proliferation of human lung cancer cells by green tea catechins is mediated by upregulation of let-7

Zhong

Dong

Yang

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. Green tea catechins are known to function as anticancer agents via inhibition of carcinogenesis during the initiation, promotion and progression stages. Many potential mechanisms have been proposed, yet the precise mechanism of lung cancer prevention by green tea catechins remains unclear. microRNAs (miRs) are a class of 21-24 nucleotide small non-coding RNAs and play critical roles throughout cellular development and regulation. Emerging evidence demonstrates that tea catechins influence the expression of miRs in human cancer cells to inhibit tumorigenesis. Both let-7a-1 and let-7g were detected in the human lung cancer cells treated with tea catechins. The cell viability and cell cycle were analyzed after tea catechins treatment. In the present study, we found that tea catechins upregulated the tumor-suppressor miRs, let-7a-1 and let-7g, in lung cancer cell lines. The upregulation of let-7a/7g repressed the expression of their targets, C-MYC and the regulatory protein of LIN-28, at the mRNA and protein levels. Moreover, the cell growth assay indicated that tea catechins significantly inhibited cell proliferation, and the flow cytometric analysis revealed an increase in the number of cells in the G2/M phase and a decrease in the number of cells in the S phase after treatment with tea catechins. These observations suggest that green tea catechins mediate the inhibition of proliferation of lung cancer cells through the let-7 signaling pathway.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of proliferation of human lung cancer cells by green tea catechins is mediated by upregulation of let-7

Zhong

Dong

Yang

et al. 2012

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

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“…In particular, miR-16 target CCDN1 and c-myc inhibiting apoptosis and promoting the entry of cells in the G1 phase of the cell cycle (Wu et al, 2011). This role was further confirmed by Tsang and Kwok (2010), who showed that the introduction of epigallocathechinagallate (EGCG) increases tissue levels of miR-16 favoring the suppression of Bcl-2. Similarly, it has been reported that serum levels of miR-16 are significantly lower in HCC than in chronic liver disease (CLD) patients or control subjects (Ge et al, 2014).…”

Section: Mir-16mentioning

confidence: 83%

HepatomiRNoma: The proposal of a new network of targets for diagnosis, prognosis and therapy in hepatocellular carcinoma

Bronte

Fanale

et al. 2016

Critical Reviews in Oncology/Hematology

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“…Viral genes can be a major regulator in DNA methylation [76]. miR-152 is frequently downregulated in HBV-HCC mice and the HepG2.2.15 cell line.…”

Section: Mirnas Add Complexity To Epigenetic Modificationmentioning

confidence: 99%

The role and clinical implications of microRNAs in hepatocellular carcinoma

Zhao

Yang

et al. 2012

Sci. China Life Sci.

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Hepatocellular carcinoma (HCC) is common and one of the most aggressive of all human cancers. Recent studies have indicated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early diagnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumorigenesis.

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Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells

Cited by 301 publications

References 33 publications

Inhibition of proliferation of human lung cancer cells by green tea catechins is mediated by upregulation of let-7

Inhibition of proliferation of human lung cancer cells by green tea catechins is mediated by upregulation of let-7

HepatomiRNoma: The proposal of a new network of targets for diagnosis, prognosis and therapy in hepatocellular carcinoma

The role and clinical implications of microRNAs in hepatocellular carcinoma

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