Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1

Sun, Weixia; Liu, Xiuxia; Zhang, Haifeng; Song, Yanyan; Li, Tie; Liu, Xiaona; Liu, Yanze; Guo, Le; Wang, Fuchun; Yang, Ting; Guo, Weiying; Wu, Junduo; Jin, Hang; Wu, Hao

doi:10.1016/j.freeradbiomed.2017.04.365

Cited by 121 publications

(99 citation statements)

References 49 publications

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“…In another very recent study, catechin administration at different dosages after cadmium exposure significantly attenuated the nephrotoxic effects of cadmium exposure by reducing oxidative stress, inflammation and by protecting the renal mitochondrial structure and function [125]. A protective role for EGCG in the development of diabetic nephropathy in mice has also been reported [126][127][128][129][130], by upregulating the nuclear factor erythroid 2-related factor 2 (NRF2), which plays a key role in cellular defence against diabetesinduced oxidative stress [130]. In a double-blind RCT, supplementation with green tea polyphenols containing 800 mg of EGCG was able to reduce albuminuria in patients with diabetic nephropathy receiving the maximum recommended dose of RAS inhibition through a reduction in the podocyte apoptosis by activation of the WNT pathway [131].…”

Section: Green Tea and Coffeementioning

confidence: 89%

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

Cosola

Sabatino

Bari

et al. 2018

Preprint

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Abstract:Chronic kidney disease (CKD) affects worldwide 8-16% of the population. In developed countries, the most important risk factors for CKD are diabetes, hypertension and obesity, calling into question the importance of educating and acting on lifestyles and nutrition. A balanced nutrition and supplementation can indeed support the maintenance of a general health status, including preservation of renal function, and help to manage and curb the main risk factors for renal damage. While the concepts of protein and salt restriction in nephrology are historically acknowledged, the role of some nutrients on renal health and the importance of nutrition as a preventative measure for renal care are less known.In this review, we provide an overview of the demonstrated and potential actions of some selected nutrients, nutraceuticals and xenobiotics on renal health and function. The effects on kidney of fibres, proteins, fatty acids, curcumin, steviol glycosides, green tea, coffee, nitrates, nitrites, and alcohol, both direct and indirect, in CKD and non-CKD condition, are reviewed here. In a view of a functional and personalized nutrition, understanding the renal and systemic effects of dietary components is essential since many chronic conditions and CKD are related to systemic dysfunctions such as chronic low-grade inflammation.

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Section: Green Tea and Coffeementioning

confidence: 89%

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

Cosola

Sabatino

Bari

et al. 2018

Preprint

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“…A study by Sun et al (2017) showed that EGCG prevented diabetes-driven molecular changes associated with diabetic neuropathy such as fibrosis, oxidative stress and inflammation in a mouse model of streptozotocin-induced diabetes (Sun et al, 2017). However, in Nrf2 knockout animals in the same study, the protective roles of EGCG were diminished indicating that the antioxidant action of EGCG is mediated through the Nrf2 pathway (Sun et al, 2017).…”

Section: Epigallocatechin Gallatementioning

confidence: 98%

“…Apart from ROS scavenging ability, activation of Nrf2 signalling has been proposed to be a major mechanism through which EGCG alleviates oxidative stress (Han, Han, Toborek, & Hennig, ; Shin, Jeon, Park, & Chang, ; Figure and Table ). A study by Sun et al () showed that EGCG prevented diabetes‐driven molecular changes associated with diabetic neuropathy such as fibrosis, oxidative stress and inflammation in a mouse model of streptozotocin‐induced diabetes (Sun et al, ). However, in Nrf2 knockout animals in the same study, the protective roles of EGCG were diminished indicating that the antioxidant action of EGCG is mediated through the Nrf2 pathway (Sun et al, ).…”

Section: Antioxidant Dietary Compounds and Their Capacity To Combat Omentioning

confidence: 99%

“…A study by Sun et al () showed that EGCG prevented diabetes‐driven molecular changes associated with diabetic neuropathy such as fibrosis, oxidative stress and inflammation in a mouse model of streptozotocin‐induced diabetes (Sun et al, ). However, in Nrf2 knockout animals in the same study, the protective roles of EGCG were diminished indicating that the antioxidant action of EGCG is mediated through the Nrf2 pathway (Sun et al, ). Activation of Nrf2 consequently leads to up‐regulation of Nrf2 responsive genes, which can explain increased expression of antioxidant enzymes, such as SOD, GST, GSH and CAT, upon treatment with EGCG (Han et al, ; Shin et al, ).…”

Section: Antioxidant Dietary Compounds and Their Capacity To Combat Omentioning

confidence: 99%

“…For instance, EGCG at low concentration (<10 μM) prevented DNA damage caused by hydrogen peroxide in lymphoblastoid cells (Sugisawa, Kimura, Fenech, & Umegaki, 2004). Antioxidant treatment with EGCG has been suggested to prevent the progression of diabetesinduced oxidative damage and diabetic neuropathy in animal models (Sun et al, 2017). Apart from ROS scavenging ability, activation of Nrf2 signalling has been proposed to be a major mechanism through which EGCG alleviates oxidative stress (Han, Han, Toborek, & Hennig, 2012;Shin, Jeon, Park, & Chang, 2016; Figure 4 and Table 1).…”

Section: Epigallocatechin Gallatementioning

confidence: 99%

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Dietary antioxidants remodel DNA methylation patterns in chronic disease

Beetch

Harandi-Zadeh

Shen

et al. 2019

British J Pharmacology

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Chronic diseases account for over 60% of all deaths worldwide according to the World Health Organization reports. Majority of cases are triggered by environmental exposures that lead to aberrant changes in the epigenome, specifically, the DNA methylation patterns. These changes result in altered expression of gene networks and activity of signalling pathways. Dietary antioxidants, including catechins, flavonoids, anthocyanins, stilbenes and carotenoids, demonstrate benefits in the prevention and/or support of therapy in chronic diseases. This review provides a comprehensive discussion of potential epigenetic mechanisms of antioxidant compounds in reversing altered patterns of DNA methylation in chronic disease. Antioxidants remodel the DNA methylation patterns through multiple mechanisms, including regulation of epigenetic enzymes and chromatin remodelling complexes. These effects can further contribute to antioxidant properties of the compounds. On the other hand, decrease in oxidative stress itself can impact DNA methylation delivering additional link between antioxidant mechanisms and epigenetic effects of the compounds. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Role of ferroptosis inhibitors in the management of diabetes

Mohandas

Ramkumar

2022

BioFactors

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Ferroptosis, the iron‐dependent, lipid peroxide‐mediated cell death, has garnered attention due to its critical involvement in crucial physiological and pathological cellular processes. Indeed, several studies have attributed its role in developing a range of disorders, including diabetes. As accumulating evidence further the understanding of ferroptotic mechanisms, the impact this specialized mode of cell death has on diabetic pathogenesis is still unclear. Several in vivo and in vitro studies have highlighted the association of ferroptosis with beta‐cell death and insulin resistance, supported by observations of marked alterations in ferroptotic markers in experimental diabetes models. The constant improvement in understanding ferroptosis in diabetes has demonstrated it as a potential therapeutic target in diabetic management. In this regard, ferroptosis inhibitors promise to rescue pancreatic beta‐cell function and alleviate diabetes and its complications. This review article elucidates the key ferroptotic pathways that mediate beta‐cell death in diabetes, and its complications. In particular, we share our insight into the cross talk between ferroptosis and other hallmark pathogenic mediators such as oxidative and endoplasmic reticulum stress regulators relevant to diabetes progression. Further, we extensively summarize the recent developments on the role of ferroptosis inhibitors and their therapeutic action in alleviating diabetes and its complications.

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Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1

Cited by 121 publications

References 49 publications

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

Dietary antioxidants remodel DNA methylation patterns in chronic disease

Role of ferroptosis inhibitors in the management of diabetes

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