Epigenenomic and transcriptomic characterization ofNPM1-mutated CN-AML subtypes
Lia N’Guyen,
Clara Tellez-Quijorna,
Julien Vernerey
et al.
Abstract:Cytogenetic normal AML with NPM1 mutations forms a distinct AML entity, associated with an intermediate prognosis and a heterogeneous response to treatment. We previously described an epigenetic biomarker, defined by the level of H3K27me3 on 70kb of the HIST1 cluster in patient blast DNA. This epigenetic mark separates cytogenetically normal NPM1mut AML into two groups of patients differing in their survival rate following chemotherapy. To better characterize the influence of the biomarker on disease progressi… Show more
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