Epigenetic adaptations in drug-tolerant tumor cells

Mani, Nilanjana; Daiya, Ankita; Chowdhury, Rajdeep; Mukherjee, Sudeshna; Chowdhury, Shibasish

doi:10.1016/bs.acr.2022.12.006

Cited by 5 publications

(2 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As one of the important components of epigenetics, ncRNAs have been demonstrated to be important regulatory factors for every cellular process. They can affect gene expression and act as oncogenes or tumor suppressors in a variety of tumors 164–166 . Increasing evidence suggests that miRNAs play an important role in epigenetic regulation of various phenotypic states of cancer cells 167–170 .…”

Section: Key Molecular Processes In Dtcsmentioning

confidence: 99%

“…They can affect gene expression and act as oncogenes or tumor suppressors in a variety of tumors. 164 , 165 , 166 Increasing evidence suggests that miRNAs play an important role in epigenetic regulation of various phenotypic states of cancer cells. 167 , 168 , 169 , 170 miRNAs could influence genetic programs through posttranscriptional silencing of target genes either by promoting translational repression or degrading the target mRNA.…”

Section: Key Molecular Processes In Dtcsmentioning

confidence: 99%

See 1 more Smart Citation

Targeting drug‐tolerant cells: A promising strategy for overcoming acquired drug resistance in cancer cells

Song,

Lan,

Zheng

et al. 2023

MedComm

View full text Add to dashboard Cite

Drug resistance remains the greatest challenge in improving outcomes for cancer patients who receive chemotherapy and targeted therapy. Surmounting evidence suggests that a subpopulation of cancer cells could escape intense selective drug treatment by entering a drug‐tolerant state without genetic variations. These drug‐tolerant cells (DTCs) are characterized with a slow proliferation rate and a reversible phenotype. They reside in the tumor region and may serve as a reservoir for resistant phenotypes. The survival of DTCs is regulated by epigenetic modifications, transcriptional regulation, mRNA translation remodeling, metabolic changes, antiapoptosis, interactions with the tumor microenvironment, and activation of signaling pathways. Thus, targeting the regulators of DTCs opens a new avenue for the treatment of therapy‐resistant tumors. In this review, we first provide an overview of common characteristics of DTCs and the regulating networks in DTCs development. We also discuss the potential therapeutic opportunities to target DTCs. Last, we discuss the current challenges and prospects of the DTC‐targeting approach to overcome acquired drug resistance. Reviewing the latest developments in DTC research could be essential in discovering of methods to eliminate DTCs, which may represent a novel therapeutic strategy for preventing drug resistance in the future.

show abstract

Section: Key Molecular Processes In Dtcsmentioning

confidence: 99%