Epigenetic alterations and advancement of lymphoma treatment

Zhuang, Shuhui; Yang, Zhaobo; Cui, Zhuangzhuang; Zhang, Yuanyuan; Che, Fengyuan

doi:10.1007/s00277-023-05395-z

Cited by 5 publications

(2 citation statements)

References 176 publications

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“…Our findings can be explained in terms of the relevant mechanisms. Lymphomas are clonal neoplasms that arise from B-cell, T-cell, and natural killer (NK)-cell subsets at various stages of maturation ( 22 ), whereas TETs are rare tumors arising from thymic epithelial cells. The difference in origin cells of lymphomas and TETs may explain the relatively young age of those with lymphoma compared to those with TETs ( 14 ) since young people tend to have more active immune cells which can increase the risk of lymphomas emergence; meanwhile, the physiological involution of the thymus progresses with age ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

The combination of maximum standardized uptake value and clinical parameters for improving the accuracy in distinguishing primary mediastinal lymphomas from thymic epithelial tumors

Yan,

Wang,

Lei

et al. 2024

Quant Imaging Med Surg

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Background Anterior mediastinal masses are relatively uncommon, and mediastinal lymphomas are the malignancies most likely to be confused with thymic epithelial tumors (TETs). The aim of this study was to investigate whether the combination of 18 fluorine-fluorodeoxyglucose positron emission tomography-computed tomography ( 18 F-FDG PET-CT) findings and clinical parameters is useful in differentiating lymphoma from TETs in anterior mediastinal masses. Methods This retrospective study consecutively included 304 patients with anterior mediastinal masses (244 TETs and 60 lymphomas) who underwent 18 F-FDG PET-CT 1 to 2 weeks before tumor resection or biopsy between August 2016 and March 2022. The correlations between the maximum standardized uptake value (SUVmax) of tumors and clinical parameters of patients with histology subtypes were analyzed. Receiver operating characteristic curve analysis was used to obtain the optimal cutoff values of age, lactate dehydrogenase (LDH), tumor size, and SUVmax to predict lymphoma. Logistic regression analysis was used to identify potential predictive factors for lymphoma. Results Lymphoma was significantly associated with younger patient age, higher LDH level, larger tumor size, and higher SUVmax compared to TETs (P<0.001). In the modeling cohort, age ≤40.5 years, LDH level ≥197 U/L, tumor size ≥10.72 cm, and SUVmax ≥11.95 were identified as independent predictors for lymphoma with odds ratios of 20.14 [95% confidence interval (CI): 6.02–67.40; P<0.001], 4.89 (95% CI: 1.27–18.89; P=0.021), 8.82 (95% CI: 2.31–33.69; P=0.001), and 30.01 (95% CI: 6.59–136.72; P<0.001), respectively. The accuracy of age, LDH, tumor size, and SUVmax in predicting lymphoma was 84.8%, 67.8%, 85.2%, and 78.3% respectively. The combination of the four above parameters could improve the predictive accuracy to 89.1%, and in the validation cohort, this combination increased the predictive accuracy to 87.8%. Conclusions SUVmax on 18 F-FDG PET-CT has the potential ability to discriminate lymphomas from TETs in the diagnosis of anterior mediastinal masses, and the combination of SUVmax with clinical parameters can improve the diagnostic accuracy. This combination may therefore may be helpful in avoiding unnecessary operation in patients with anterior mediastinal lymphomas.

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Section: Discussionmentioning

confidence: 99%

The combination of maximum standardized uptake value and clinical parameters for improving the accuracy in distinguishing primary mediastinal lymphomas from thymic epithelial tumors

Yan,

Wang,

Lei

et al. 2024

Quant Imaging Med Surg

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“…The heterogeneity of lymphoma derives from the diversity of lymphocytes and their genetic and epigenetic abnormalities [37–39]. Each lymphoma subtype differs in pathogenesis, clinical features, treatment modalities, response to therapy, and prognosis assessment [40]. In the study, 76.7% (33/43) of lymphoma patients were diagnosed as DLBCLs, which are phenotypically and genetically heterogeneous.…”

Section: Discussionmentioning

confidence: 99%

Differentiation of cancer of unknown primary and lymphoma in head and neck metastatic poorly differentiated cancer using 18F-FDG PET/CT tumor metabolic heterogeneity index

Xu,

Gu,

Zhang

et al. 2023

Nuclear Medicine Communications

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Objective To explore the value of 18F-FDG PET/CT tumor metabolic heterogeneity index (HI) and establish and validate a nomogram model for distinguishing head and neck cancer of unknown primary (HNCUP) from lymphoma with head and neck metastatic poorly differentiated cancer. Methods This retrospective analysis was conducted on 1242 patients with cervical metastatic poorly differentiated cancer. 108 patients, who were clinically and pathologically confirmed as HNCUP or lymphoma, were finally enrolled. Two independent sample t-tests and χ2 test were used to compare the clinical and imaging features. Binary logistic regression was used to screen for independent predictive factors. Results Among the 108 patients), 65 patients were diagnosed with HNCUP and 43 were lymphoma. Gender (P = 0.001), SUVmax (P < 0.001), SUVmean (P < 0.001), TLG (P = 0.012), and HI (P < 0.001) had statistical significance in distinguishing HNCUP and lymphoma. Female (OR = 4.546, P = 0.003) and patients with HI ≥ 2.37 (OR = 3.461, P = 0.047) were more likely to be diagnosed as lymphoma. Conclusion For patients with cervical metastatic poorly differentiated cancer, gender and HI were independent predictors of pathological type. For such patients, clinical attention should be paid to avoid misdiagnosing lymphoma as HNCUP, which may delay treatment.

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YTHDC1 is a therapeutic target for B-cell acute lymphoblastic leukemia by attenuating DNA damage response through the KMT2C-H3K4me1/me3 epigenetic axis

Li,

Zheng,

et al. 2024

Leukemia

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Epigenetic alterations and advancement of lymphoma treatment

Cited by 5 publications

References 176 publications

The combination of maximum standardized uptake value and clinical parameters for improving the accuracy in distinguishing primary mediastinal lymphomas from thymic epithelial tumors

The combination of maximum standardized uptake value and clinical parameters for improving the accuracy in distinguishing primary mediastinal lymphomas from thymic epithelial tumors

Differentiation of cancer of unknown primary and lymphoma in head and neck metastatic poorly differentiated cancer using 18F-FDG PET/CT tumor metabolic heterogeneity index

YTHDC1 is a therapeutic target for B-cell acute lymphoblastic leukemia by attenuating DNA damage response through the KMT2C-H3K4me1/me3 epigenetic axis

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