Epigenetic Alterations Associated with the Overall Survival and Recurrence Free Survival among Oral Squamous Cell Carcinoma Patients

Ghantous, Yasmine; Nashef, Aysar; Abu-El-Naaj, Imad

doi:10.3390/jcm9041035

Cited by 16 publications

(17 citation statements)

References 46 publications

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“…It is commonly believed that epigenetic changes, such as DNA methylation, can drive abnormal gene expression of crucial genes involved in the development and progression of cancer, including head and neck cancer 35 . Hypermethylation of tumor suppressor genes and hypomethylation of proto-oncogenes at the promoter sites are associated with carcinogenesis and progression of OSCC 36 , 37 . For example, several studies have suggested that hypermethylation of PAX1 and ZNF582 genes is associated with aggressive progression and poor survival 38 – 40 .…”

Section: Discussionmentioning

confidence: 99%

Prognostic and therapeutic prediction by screening signature combinations from transcriptome–methylome interactions in oral squamous cell carcinoma

Shi

Liu

Tian

et al. 2022

Sci Rep

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DNA methylation pattern in oral squamous cell carcinoma (OSCC) remains poorly described. This study aimed to perform a genome-wide integrated analysis of the transcriptome and methylome and assess the efficacy of their prognostic signature model in patients with OSCC. We analyzed transcriptome and methylome data from 391 OSCC samples and 41 adjacent normal samples. A total of 8074 differentially expressed genes (DEGs) and 10,084 differentially expressed CpGs (DMCpGs) were identified. Then 241 DEGs with DMCpGs were identified. According to the prognostic analysis, the prognostic signature of methylation-related differentially expressed genes (mrDEGPS) was established. mrDEGPS consisted of seven prognostic methylation-related genes, including ESRRG, CCNA1, SLC20A1, COL6A6, FCGBP, CDKN2A, and ZNF43. mrDEGPS was a significant stratification factor of survival (P < 0.00001) irrespective of the clinical stage. The immune effector components, including B cells, CD4+ T cells, and CD8+ T cells, were decreased in the tumor environment of patients with high mrDEGPS. Immune checkpoint expressions, including CTLA-4, PD-1, LAG3, LGALS9, HAVCR2, and TIGHT, were comprehensively elevated (P < 0.001). The estimated half-maximal inhibitory concentration difference between low- and high-risk patients was inconsistent among chemotherapeutic drugs. In conclusion, the transcriptome–methylome interaction pattern in OSCC is complex. mrDEGPS can predict patient survival and responses to immunotherapy and chemotherapy and facilitate clinical decision-making in patients with OSCC.

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Section: Discussionmentioning

confidence: 99%

Prognostic and therapeutic prediction by screening signature combinations from transcriptome–methylome interactions in oral squamous cell carcinoma

Shi

Liu

Tian

et al. 2022

Sci Rep

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“…Squamous cell carcinoma (SCC) of oral cavity is a fatal disease caused by complex interactions between environmental, genomic and epigenetic alterations [ 61 ]. Surgical resection with microscopically clear margins of the primary tumor and prophylactic or therapeutic clearance of the neck lymph nodes, followed by various reconstructive approaches, remains the fundamental treatment for Oral Squamous Cell Carcinoma (OSCC) with adjuvant therapy reserved for high-risk disease [ 62 , 63 , 64 , 65 , 66 ].…”

Section: Am Process In Virtual Surgical Treatment Planning Surgicmentioning

confidence: 99%

Three-Dimensional Technology Applications in Maxillofacial Reconstructive Surgery: Current Surgical Implications

et al. 2020

Self Cite

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Defects in the oral and maxillofacial (OMF) complex may lead to functional and esthetic impairment, aspiration, speech difficulty, and reduced quality of life. Reconstruction of such defects is considered one of the most challenging procedures in head and neck surgery. Transfer of different auto-grafts is still considered as the “gold standard” of regenerative and reconstructive procedures for OMF defects. However, harvesting of these grafts can lead to many complications including donor-site morbidity, extending of surgical time, incomplete healing of the donor site and others. Three-dimensional (3D) printing technology is an innovative technique that allows the fabrication of personalized implants and scaffolds that fit the precise anatomy of an individual’s defect and, therefore, has attracted significant attention during the last few decades, especially among head and neck surgeons. Here we discuss the most relevant applications of the 3D printing technology in the oral and maxillofacial surgery field. We further show different clinical examples of patients who were treated at our institute using the 3D technology and discuss the indications, different technologies, complications, and their clinical outcomes. We demonstrate that 3D technology may provide a powerful tool used for reconstruction of various OMF defects, enabling optimal clinical results in the suitable cases.

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“…The incidence of oral cavity cancer is estimated to increase by up to 40% by 2040, with a corresponding increase in mortality also predicted [2]. Oral cavity cancer is reportedly most common in South and Southeast Asia and some countries in southern Europe [3]. Histologically, oral cavity squamous cell carcinoma (OSCC) is by far the most frequent type of oral cavity cancer and accounts for more than 90% of cases.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Neutrophil Percentage-to-Albumin Ratio in Patients with Oral Cavity Cancer

Fang

Tsai

et al. 2022

Cancers

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This study investigated preoperative neutrophil percentage-to-albumin ratio (NPAR) for predicting oral cavity squamous cell carcinoma (OSCC) survival. We retrospectively analyzed 368 patients who received curative OSCC surgery between 2008 and 2017. Receiver operating characteristic curve analyses were employed to identify the optimal NPAR cutoff (16.93), and the patients were then separated into low-NPAR and high-NPAR groups. Intergroup differences in survival were determined through Kaplan–Meier analysis and log-rank tests. Disease-free survival (DFS) and overall survival (OS) predictors were identified using Cox proportional-hazards models. A nomogram integrating independent prognostic factors was proposed to increase the accuracy of OS prediction. A high NPAR (≥16.93) was associated with worse median OS and DFS than was a low NPAR (both p < 0.001); this finding was confirmed through multivariate analyses (hazard ratio (HR) for OS = 2.697, p < 0.001; and HR for DFS = 1.671, p = 0.008). The nomogram’s favorable predictive ability was confirmed by the calibration plots and concordance index (0.784). The preoperative NPAR is thus a promising prognostic biomarker in patients with OSCC after external validation in a larger cohort. Our nomogram can facilitate clinical use of the NPAR and provides accurate individualized OS predictions.

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Epigenetic Alterations Associated with the Overall Survival and Recurrence Free Survival among Oral Squamous Cell Carcinoma Patients

Cited by 16 publications

References 46 publications

Prognostic and therapeutic prediction by screening signature combinations from transcriptome–methylome interactions in oral squamous cell carcinoma

Prognostic and therapeutic prediction by screening signature combinations from transcriptome–methylome interactions in oral squamous cell carcinoma

Three-Dimensional Technology Applications in Maxillofacial Reconstructive Surgery: Current Surgical Implications

Prognostic Value of Neutrophil Percentage-to-Albumin Ratio in Patients with Oral Cavity Cancer

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