Epigenetic approach in obesity: DNA methylation in a prepubertal population which underwent a lifestyle modification

Gallardo-Escribano, Cristina; Buonaiuto, Verónica; Ruiz-Moreno, María Isabel; Vargas-Candela, Antonio; Vilches-Pérez, Alberto; Benítez-Porres, Javier; Romance-García, Ángel Ramón; Ruiz-Moreno, Alejandro; Huelgas, Ricardo Gómez; Bernal-López, Rosa

doi:10.1186/s13148-020-00935-0

Cited by 23 publications

(20 citation statements)

References 47 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Activated macrophages polarize towards various functional phenotypes [ 67 ]. Future targeting of specific epigenetic pathways in cardiovascular disease may, thus, offer exciting novel approaches for the treatment of disease [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

“…Cardiovascular diseases contribute from a multifactorial and complex interplay of genetic, environmental, and lifestyle factors [ 53 ]. Epigenetic changes can modify gene transcription by altering the accessibility of gene transcription machinery, and these changes are predisposed by factors of nutrition, inflammation, sex, age, and lifestyle changes [ 54 ]. Chronic exposure to novel lifestyle factors coinciding with disease mechanisms involving chronic low-grade systemic inflammation affects vascular health [ 2 ].…”

Section: Epigenetics and Cardiovascular Diseases (Cvd)mentioning

confidence: 99%

See 1 more Smart Citation

Emerging Role of Epigenetics in Explaining Relationship of Periodontitis and Cardiovascular Diseases

et al. 2021

View full text Add to dashboard Cite

Cardiovascular diseases such as ischemic heart diseases or stroke are among the leading cause of deaths globally, and evidence suggests that these diseases are modulated by a multifactorial and complex interplay of genetic, environmental, and lifestyle factors. Genetic predisposition and chronic exposure to modifiable risk factors have been explored to be involved in the pathophysiology of CVD. Environmental factors contribute to an individual’s propensity to develop major cardiovascular risk factors through epigenetic modifications of DNA and histones via miRNA regulation of protein translation that are types of epigenetic mechanisms and participate in disease development. Periodontal disease (PD) is one of the most common oral diseases in humans that is characterized by low-grade inflammation and has been shown to increase the risk of CVDs. Risk factors involved in PD and CVD are determined both genetically and behaviorally. Periodontal diseases such as chronic inflammation promote DNA methylation. Epigenetic modifications involved in the initiation and progression of atherosclerosis play an essential role in plaque development and vulnerability. Epigenetics has opened a new world to understand and manage human diseases, including CVDs and periodontal diseases. Genetic medicine has started a new era of epigenetics to overcome human diseases with various new methodology. Epigenetic profiling may aid in better diagnosis and stratification of patients showing potential predisposed states for disease. A better understanding of the exact regulatory mechanisms of epigenetic pathways driving inflammation is slowly emerging and will aid in developing novel tools for the treatment of disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Epigenetics and Cardiovascular Diseases (Cvd)mentioning

confidence: 99%

Emerging Role of Epigenetics in Explaining Relationship of Periodontitis and Cardiovascular Diseases

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The lnc-MEG3 provoked apoptosis of trophoblast cells via NF-κB and Bax/Bcl2 signaling pathways [9]; also, Yu et al declared that the lnc-MEG3 downregulation is involved in PE through suppression of migration, invasion, and EMT of placental trophoblast cells by TGF-β pathway inhibitors [5]. Epigenetic changes such as DNA methylation are in uenced by environmental factors including life style [25].…”

Section: Discussionmentioning

confidence: 99%

Preeclampsia and Keap1 (rs11085735) variants and lncRNA MEG3 methylation status: Association with lncRNA MEG3 hypermethylation

Zangeneh

Heydarian

Seifi

et al. 2021

Preprint

View full text Add to dashboard Cite

Background. Preeclampsia (PE) is one of the complications of pregnancy. Genetic and epigenetic mechanisms are involved in the preeclampsia pathophysiology. The aims of present study were to investigate the role of Keap1 (rs11085735) variants and the methylation status of long non-coding RNA-maternally expressed gene 3 (lncRNA MEG3) in the pathogenesis of PE in a population from Western Iran with Kurdish ethnic background.Results. There was no significant difference in the frequency of Keap1 genotypes comparing 75 patients with PE and 75 women with normal pregnancy. The frequencies of hemi methylated and full methylated lnc-MEG3 were 94 and 6% (P=0.04), respectively in all patients (50 women), 86.4, and 13.6% (P=0.04), respectively in patients with severe preeclampsia and 98 and 0% in controls (50 women). The frequency of full methylated lnc-MEG3 was 14.3% in early-onset and 2.8% in late-onset preeclampsia (P=0.12). The frequency of full methylated lnc-MEG3 was higher in patients with BMI >25 kg/m2 compared to normal weight patients. The PE patients had significantly higher levels of liver biomarkers (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total bilirubin) and significantly lower platelet count than healthy pregnant women. Conclusions. Hypermethylation status of lnc-MEG3 increased in patients with PE compared to controls that could be contributed in the pathogenesis and development of preeclampsia and its severe form. However, Keap1 variants might not be involved in the pathogenesis of preeclampsia.

show abstract

“…It is frequently suggested that the main factor contributing to varying degrees of obesity susceptibility may be epigenetics and gene expression [ 130 , 131 , 132 ]. First studies concerning the role of DNA methylation in obesity were conducted in 2013 by Xu et al, in which the authors identified several CpG sites and DNA methylation variances associated with obesity in young African Americans [ 133 ].…”

Section: Genetic Determinants Of Obesity In the Context Of The Endmentioning

confidence: 99%

What Role Does the Endocannabinoid System Play in the Pathogenesis of Obesity?

et al. 2021

View full text Add to dashboard Cite

The endocannabinoid system (ECS) is an endogenous signaling system formed by specific receptors (cannabinoid type 1 and type 2 (CB1 and CB2)), their endogenous ligands (endocannabinoids), and enzymes involved in their synthesis and degradation. The ECS, centrally and peripherally, is involved in various physiological processes, including regulation of energy balance, promotion of metabolic process, food intake, weight gain, promotion of fat accumulation in adipocytes, and regulation of body homeostasis; thus, its overactivity may be related to obesity. In this review, we try to explain the role of the ECS and the impact of genetic factors on endocannabinoid system modulation in the pathogenesis of obesity, which is a global and civilizational problem affecting the entire world population regardless of age. We also emphasize that the search for potential new targets for health assessment, treatment, and the development of possible therapies in obesity is of great importance.

show abstract

Epigenetic approach in obesity: DNA methylation in a prepubertal population which underwent a lifestyle modification

Cited by 23 publications

References 47 publications

Emerging Role of Epigenetics in Explaining Relationship of Periodontitis and Cardiovascular Diseases

Emerging Role of Epigenetics in Explaining Relationship of Periodontitis and Cardiovascular Diseases

Preeclampsia and Keap1 (rs11085735) variants and lncRNA MEG3 methylation status: Association with lncRNA MEG3 hypermethylation

What Role Does the Endocannabinoid System Play in the Pathogenesis of Obesity?

Contact Info

Product

Resources

About