Epigenetic Basis of Polyphenols in Cancer Prevention and Therapy

Kaleem, Mohammed; Alhosin, Mahmoud; Khan, Kabiruddin; Ahmad, Wasim; Hosawi, Salman; Nur, Suza Mohammad; Choudhry, Hani; Zamzami, Mazin A.; Al‐Abbasi, Fahad A.; Javed, Nazir

doi:10.1007/978-981-16-4935-6_6

Cited by 4 publications

(2 citation statements)

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“…Epigenetic modifications, encompassing DNA methylation, histone methylation, or acetylation, significantly influence abnormal gene expressions during tumor initiation and progression (Kanwal & Gupta, 2012). Polyphenols act as epigenetic modifiers, influencing DNA and histone modifications, and play a crucial role in regulating key lncRNAs (Kaleem et al, 2021). For instance, curcumin inhibits the transcription of lncRNA PVT1 in pancreatic ductal adenocarcinoma cells by disrupting the expression of the PRC2 subunit EZH2 (Yoshida et al, 2017).…”

Section: Resveratrolmentioning

confidence: 99%

Modulation of long noncoding RNAs by polyphenols as a novel potential therapeutic approach in lung cancer: A comprehensive review

Lv,

Qian,

et al. 2024

Phytotherapy Research

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Lung cancer stands as a formidable global health challenge, necessitating innovative therapeutic strategies. Polyphenols, bioactive compounds synthesized by plants, have garnered attention for their diverse health benefits, particularly in combating various cancers, including lung cancer. The advent of whole‐genome and transcriptome sequencing technologies has illuminated the pivotal roles of long noncoding RNAs (lncRNAs), operating at epigenetic, transcriptional, and posttranscriptional levels, in cancer progression. This review comprehensively explores the impact of polyphenols on both oncogenic and tumor‐suppressive lncRNAs in lung cancer, elucidating on their intricate regulatory mechanisms. The comprehensive examination extends to the potential synergies when combining polyphenols with conventional treatments like chemotherapy, radiation, and immunotherapy. Recognizing the heterogeneity of lung cancer subtypes, the review emphasizes the need for the integration of nanotechnology for optimized polyphenol delivery and personalized therapeutic approaches. In conclusion, we collect the latest research, offering a holistic overview of the evolving landscape of polyphenol‐mediated modulation of lncRNAs in lung cancer therapy. The integration of polyphenols and lncRNAs into multidimensional treatment strategies holds promise for enhancing therapeutic efficacy and navigating the challenges associated with lung cancer treatment.

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Section: Resveratrolmentioning

confidence: 99%

Modulation of long noncoding RNAs by polyphenols as a novel potential therapeutic approach in lung cancer: A comprehensive review

Lv,

Qian,

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…[1][2][3] It is caused by an imbalance between the expression of oncogenes and proto-oncogenes, which is caused by genetic and epigenetic abnormalities. 4,5 Globally, the number of cancer diagnoses has climbed to 19.3 million, and each year, 10 million deaths related to cancer are reported. The most common type of cancer among women is breast cancer (BC), globally.…”

Section: Introductionmentioning

confidence: 99%