2015
DOI: 10.1681/asn.2014121161
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Epigenetic Changes Induced by Hypoxia-Inducible Factor

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Cited by 9 publications
(6 citation statements)
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“…; Nangaku et al . ), beyond the scope of this review. The complex scheme of HIF generation and degradation, with differential expression and regulation of various components, may explain cell‐ and organ‐specific susceptibility to hypoxic insults, with diverse phenotypic outcomes and biological function.…”
Section: Hypoxia‐inducible Factors (Hifs)mentioning
confidence: 92%
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“…; Nangaku et al . ), beyond the scope of this review. The complex scheme of HIF generation and degradation, with differential expression and regulation of various components, may explain cell‐ and organ‐specific susceptibility to hypoxic insults, with diverse phenotypic outcomes and biological function.…”
Section: Hypoxia‐inducible Factors (Hifs)mentioning
confidence: 92%
“…The HIF αβ heterodimers, either directly or through mediators such as miR‐687, induce transient epigenetic changes in the DNA, with histone modification and chromosomal conformational changes, leading to transactivation of HIF‐target genes (Nangaku et al . ). Over 2000 HREs were identified along the mouse genome and there are over 200 genes clearly controlled by HIF (Schödel et al .…”
Section: Hypoxia‐inducible Factors (Hifs)mentioning
confidence: 97%
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“…Specifically, studies of cultured tubular cells have shown that the transcriptional factor hypoxia-inducible factor-1 (HIF-1), targeting genes involved in erythropoiesis and angiogenesis to increase oxygen delivery, induces miR-687 expression during hypoxia. Up-regulation of miR-687, in turn, results in repression of the tumour suppressor phosphatase and tensin homologue (PTEN) gene, cell cycle activation and accelerated kidney repair [218]. Intriguingly, in vivo studies showed paradoxical results, as mice treated with anti-mir-687 were protected against kidney injury.…”
Section: Microrna-based Therapy In Ckdmentioning
confidence: 99%
“…In the brain, it attenuates ischemic injury caused by proinflammatory cytokines. miR-205 regulates HIF-1 expression [50]. HIF-1 in turn modulates expression of miR-21 [51], a miRNA thought to play a protective antiapoptotic role against ischemic injury.…”
Section: Mirna In Cerebrovascular Diseasesmentioning
confidence: 99%