2003
DOI: 10.1111/j.1749-6632.2003.tb05962.x
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Epigenetic Control during Lymphoid Development and Immune Responses

Abstract: Methylation of cytosines controls a number of biologic processes such as imprinting and X chromosomal inactivation. DNA hypermethylation is closely associated with transcriptional silencing, while DNA hypomethylation is associated with transcriptional activation. Hypoacetylation of histones leads to compact chromatin with reduced accessibility to the transcriptional machinery. Methyl-CpG binding proteins can recruit corepressors and histone deacetylases; thus, the interplay between these epigenetic mechanisms … Show more

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Cited by 18 publications
(12 citation statements)
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References 108 publications
(111 reference statements)
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“…21 This could originate from abnormal epigenetic modifications stably induced in cells of lymphoid tissues, affecting not only cytokine production but also B-cell traffic and homing, resulting in insufficient B-cell stimulation and/or an insufficient period of time of B-cell differentiation. [51][52][53][54] Abnormal cytokine release pattern or kinetics, the regulation of cellular signaling pathway intermediates, and the putative threshold effect in collaboration between cytokines such as IL-21 and IL-4 on B-cell activation could also account for the failure of in vivo B-cell differentiation in IgAD and CVID. 43,[55][56][57] In conclusion, our findings shed light on the potential immunotherapeutic perspective of IL-21 to revert the differentiation blockage of Ig-committed B cells and to expand the proportion of Ig-producing switched B cells in CVID and IgAD.…”
Section: Discussionmentioning
confidence: 99%
“…21 This could originate from abnormal epigenetic modifications stably induced in cells of lymphoid tissues, affecting not only cytokine production but also B-cell traffic and homing, resulting in insufficient B-cell stimulation and/or an insufficient period of time of B-cell differentiation. [51][52][53][54] Abnormal cytokine release pattern or kinetics, the regulation of cellular signaling pathway intermediates, and the putative threshold effect in collaboration between cytokines such as IL-21 and IL-4 on B-cell activation could also account for the failure of in vivo B-cell differentiation in IgAD and CVID. 43,[55][56][57] In conclusion, our findings shed light on the potential immunotherapeutic perspective of IL-21 to revert the differentiation blockage of Ig-committed B cells and to expand the proportion of Ig-producing switched B cells in CVID and IgAD.…”
Section: Discussionmentioning
confidence: 99%
“…For instance, HDACi and DNMT inhibitors have been tested for the treatment of aggressive non-Hodgkin's Lymphomas (NHLs) [136][137][138][139][140][141][142][143][144][145].…”
Section: Hematological Malignanciesmentioning
confidence: 99%
“…8,12 Such inappropriate methylation has been observed during the infection process of several different viruses. 18 Viral infection of human cells disrupts the dynamics of the epigenome presumably through the methylation of the viral genome and the de novo methylation of host genes. 19,20 The alteration of cellular methylation patterns in some cases leads to the mutation or repression of tumor suppressor genes (p16 INK4A , von Hippel-Lindau, BRCA1).…”
Section: Introductionmentioning
confidence: 99%