2015
DOI: 10.1073/pnas.1424089112
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Epigenetic control of intestinal barrier function and inflammation in zebrafish

Abstract: The intestinal epithelium forms a barrier protecting the organism from microbes and other proinflammatory stimuli. The integrity of this barrier and the proper response to infection requires precise regulation of powerful immune homing signals such as tumor necrosis factor (TNF). Dysregulation of TNF leads to inflammatory bowel diseases (IBD), but the mechanism controlling the expression of this potent cytokine and the events that trigger the onset of chronic inflammation are unknown. Here, we show that loss o… Show more

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Cited by 170 publications
(180 citation statements)
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“…; Marjoram et al . ). It has been recently shown that TNF‐α can stimulate epithelial cell proliferation, and this occurs only when, in combination with IFN‐γ, TNF‐α induces epithelial cell apoptosis (Nava et al .…”
Section: Discussionmentioning
confidence: 97%
“…; Marjoram et al . ). It has been recently shown that TNF‐α can stimulate epithelial cell proliferation, and this occurs only when, in combination with IFN‐γ, TNF‐α induces epithelial cell apoptosis (Nava et al .…”
Section: Discussionmentioning
confidence: 97%
“…Promoter methylation of TNF-α, a strong pro-inflammatory cytokine, for example, has been identified as a triggering event in chronic inflammatory bowel disease [8] . Epigenetic modifiers, such as ten-eleven translocation proteins, mediate active chromatin regulation in a genespecific manner, eventually leading to repression of inflammatory gene transcription, such as interleukin (IL)-6 [9] .…”
Section: Introductionmentioning
confidence: 99%
“…Abnormal host-microbiota interactions are strongly implicated in the pathogenesis of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC) (Sartor and Wu 2016). Studies in mouse and zebrafish models of IBD have established that impaired intestinal epithelial cell (IEC) responses to microbiota are a key aspect of disease progression (Bates et al 2007;Kamada et al 2013;Marjoram et al 2015). Improved understanding of the molecular mechanisms by which microbiota evoke host responses in the intestinal epithelium can be expected to lead to new strategies for preventing or treating IBD and other microbiota-associated diseases.…”
mentioning
confidence: 99%