2021
DOI: 10.1016/j.dci.2020.103840
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Epigenetic control of myeloid cells behavior by Histone Deacetylase activity (HDAC) during tissue and organ regeneration in Xenopus laevis

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Cited by 5 publications
(5 citation statements)
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“…The red dashed line indicates the amputation plane cellular level, ROC (regeneration-organizing cell) migration and high levels of apoptosis was observed during the refractory period compared to the regenerationcompetent stage [6,7]. In addition, studies have shown that immune and inflammatory signaling pathways are tightly regulated during tail regeneration [8] and that regeneration can be enabled during the refractory period by activating either BMP or Notch signaling pathways [9]. However, the role of these pathways, particularly the endogenous genes, have not been investigated due to the difficulty for genetic studies in the pseudo-tetraploid organism.…”
Section: Open Accessmentioning
confidence: 99%
“…The red dashed line indicates the amputation plane cellular level, ROC (regeneration-organizing cell) migration and high levels of apoptosis was observed during the refractory period compared to the regenerationcompetent stage [6,7]. In addition, studies have shown that immune and inflammatory signaling pathways are tightly regulated during tail regeneration [8] and that regeneration can be enabled during the refractory period by activating either BMP or Notch signaling pathways [9]. However, the role of these pathways, particularly the endogenous genes, have not been investigated due to the difficulty for genetic studies in the pseudo-tetraploid organism.…”
Section: Open Accessmentioning
confidence: 99%
“…Hence, for a long time, many researchers have been comparing embryogenesis and regeneration with an intention to use knowledge on embryonic development to unlock hidden regenerative potential and eventually aid in the development of regenerative medicines [38]. Interestingly, our study has revealed here numerous genes and pathways involved in tail development, such as Hippo signaling pathway, smad1/5/8, Id, Hes1/5, Mps1, Slug and HDAC, etc., reported to be important for regeneration [32,[39][40][41][42][43][44][45]. Slug in Hippo signaling pathway has been reported to modulate mammary epithelial stem cell activity and differentiation in vivo and the absence of Slug lead to the loss of mammary stem cell activity necessary for tissue regeneration and cancer initiation [44].…”
Section: Discussionmentioning
confidence: 99%
“…PACs derived from the first wave of hematopoiesis appear to employ less components of the ancestral PAC toolkit. This view is supported by the fact that first‐wave PACs are mostly involved in establishing the regenerative tissue repair response because the knockdown of the amphibian PAC master gene SpiB correlates with impairment of the regenerative tissue repair program 146 . In addition, loss‐of‐function experiments have demonstrated that ablation of PACs (macrophages) in urodele amphibians culminates in high levels of inflammatory cytokines and low levels of anti‐inflammatory mediators 4 …”
Section: Deuterostomiamentioning
confidence: 99%
“…This view is supported by the fact that first-wave PACs are mostly involved in establishing the regenerative tissue repair response because the knockdown of the amphibian PAC master gene SpiB correlates with impairment of the regenerative tissue repair program. 146 In addition, loss-of-function experiments have demonstrated that ablation of PACs (macrophages) in urodele amphibians culminates in high levels of inflammatory cytokines and low levels of anti-inflammatory mediators. 4 However, the decrease in regenerative tissue repair potential observed during metamorphosis overlaps the increase in adaptive cell and lymphoid organ development.…”
Section: Amphibian Pacs: Hematopoieticderived Cells That Belong To Th...mentioning
confidence: 99%