Epigenetic Control of the Host Gene by Commensal Bacteria in Large Intestinal Epithelial Cells

Takahashi, Kyôko; Sugi, Yutaka; Nakano, Kou; Tsuda, Masato; Kurihara, Kenta; Hosono, Akira; Kaminogawa, Shuichi

doi:10.1074/jbc.m111.271007

Cited by 151 publications

(126 citation statements)

References 33 publications

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“…Evidence for the involvement of underlying epigenetic modifications in long-term studies emerges with regard to the gastrointestinal tract. More precisely, microbiota is involved in modulating the host epigenome at the gut level [28,29]. Such results, in addition to their well-known prebiotic properties, lead to the idea that scFOS may modulate early bacterial colonization of piglets and by this way modulate metabolic responses later on.…”

Section: Scfos Supplementation Results In Long-term Effects On Growthmentioning

confidence: 99%

Effect of Dietary Supplementation with Short-Chain Fructooligosaccharides in Lactating Sows and Newly Weaned Piglets on Reproductive Performance of Sows, Immune Response and Growth Performance of Piglets from Birth to Slaughter

Apper¹,

Meymerit²,

Bodin³

et al. 2016

J Anim Res Nutr

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Objective: The effects of an early-life dietary supplementation with short-chain fructooligosaccharides (scFOS) on immune response and growth performance of pigs from birth to slaughter were evaluated. The hypothesis was that scFOS have long-term effects on immune response, and growth performance. Methods:One hundred and twenty-nine sows received a control diet (CTRL, 10 g/d maltodextrins) or a diet supplemented with scFOS (10 g/d) from d 109 of gestation to the weaning of the piglets.After weaning, the piglets of each litter were divided into two groups to receive the CTRL or the scFOS diet (1.2 g/d maltodextrin or scFOS) during the pre-starter period. At 53 and 74 d of age, the piglets were vaccinated against Influenza.Performance of sows and composition of colostrum were measured. Blood serum of the piglets was sampled one d prior vaccination, at d 74 and 95 to measure Influenza-IgG levels. The growth parameters of the piglets were recorded from birth to slaughter. Results:Supplementation of the sows with scFOS decreased farrowing duration (p=0.012), colostrum fat content (p=0.006) and increased IgG content in colostrum of sows with parity of 4 or higher (p=0.006) without modifying the performance of suckling piglets. Back fat thickness at weaning tended to be higher in supplemented sows (p=0.091). Diet with scFOS improved growth performance during the breeding period, resulting in reduced feeding time needed to reach a 120 kg body weight at slaughter. Piglets fed scFOS had higher Influenza-IgG titer (p=0.05) after vaccination against Influenza virus. Conclusion:These data suggest scFOS supplementation of sows during suckling period and of piglets during the postweaning period leads to long-term positive effects on growth of fattening pigs and to better physiological conditions of sows.

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Section: Scfos Supplementation Results In Long-term Effects On Growthmentioning

confidence: 99%

Effect of Dietary Supplementation with Short-Chain Fructooligosaccharides in Lactating Sows and Newly Weaned Piglets on Reproductive Performance of Sows, Immune Response and Growth Performance of Piglets from Birth to Slaughter

Apper¹,

Meymerit²,

Bodin³

et al. 2016

J Anim Res Nutr

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“…In the intestine, some PRC2 target genes are subject to aberrant DNA methylation following chronic inflammation (Hahn et al 2008). In a noninflammatory context, the LPS-sensing receptor encoding gene TLR4 is down-regulated in intestinal epithelial cells and there is evidence for a role of commensal bacteria in TLR4 methylation (Takahashi et al 2011). This is proposed to maintain intestinal homeostasis by preventing an excessive inflammatory reaction toward the gut microbiota.…”

Section: Dna Methylationmentioning

confidence: 99%

Epigenetics and Bacterial Infections

Bierne¹,

Hamon²,

Cossart³

2012

Cold Spring Harbor Perspectives in Medicine

315

230

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Epigenetic mechanisms regulate expression of the genome to generate various cell types during development or orchestrate cellular responses to external stimuli. Recent studies highlight that bacteria can affect the chromatin structure and transcriptional program of host cells by influencing diverse epigenetic factors (i.e., histone modifications, DNA methylation, chromatin-associated complexes, noncoding RNAs, and RNA splicing factors). In this article, we first review the molecular bases of the epigenetic language and then describe the current state of research regarding how bacteria can alter epigenetic marks and machineries. Bacterial-induced epigenetic deregulations may affect host cell function either to promote host defense or to allow pathogen persistence. Thus, pathogenic bacteria can be considered as potential epimutagens able to reshape the epigenome. Their effects might generate specific, long-lasting imprints on host cells, leading to a memory of infection that influences immunity and might be at the origin of unexplained diseases.

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“…Commensal bacteriaderived signals also influence host epigenetic pathways, particularly through DNA and histone methylation [32][33][34][35][36] and histone acetylation and deacetylation [37][38][39][40][41] . The commensal microbiota produces multiple low-molecular-weight byproducts that modify the host cell epigenome and may alter the functional behavior of host cells.…”

Section: Special Issue (Mini Review) Gut Microbiota and Epigeneticsmentioning

confidence: 99%

Commensal microbiota-derived signals regulate host immune system through epigenetic modifications

Takahashi

Hase

2015

Inflammation and Regeneration

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Commensal microbiota colonizing the digestive tract is a symbiotic partner of its host, as it plays a critical role in nutrient metabolism as well as the development and maturation of the host immune system. Although it is clear that regulation of the host-commensal relationship is crucial to mammalian health, the underlying mechanisms regulating gut homeostasis are yet to be elucidated. Epigenetic modifications, including DNA methylation and histone methylation/acetylation, alter the structure of chromatin to regulate the transcriptional program of eukaryotic cells. At the whole genome level, these modifications possibly play a key role in regulating the mutually beneficial relationship between the host and the gut microbiota. In this review, we describe how the commensal microbiota and its metabolic by-products modify the epigenome of host cells, and in turn, change their development and functional behavior.Rec.2/24/2015, Acc.3/1/2015, pp129-136

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Epigenetic Control of the Host Gene by Commensal Bacteria in Large Intestinal Epithelial Cells

Cited by 151 publications

References 33 publications

Effect of Dietary Supplementation with Short-Chain Fructooligosaccharides in Lactating Sows and Newly Weaned Piglets on Reproductive Performance of Sows, Immune Response and Growth Performance of Piglets from Birth to Slaughter

Effect of Dietary Supplementation with Short-Chain Fructooligosaccharides in Lactating Sows and Newly Weaned Piglets on Reproductive Performance of Sows, Immune Response and Growth Performance of Piglets from Birth to Slaughter

Epigenetics and Bacterial Infections

Commensal microbiota-derived signals regulate host immune system through epigenetic modifications

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