Epigenetic diet: impact on the epigenome and cancer

Hardy, Tabitha M.; Tollefsbol, Trygve O.

doi:10.2217/epi.11.71

Cited by 331 publications

(242 citation statements)

References 213 publications

(217 reference statements)

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“…2D), a trend also found in hepatocellular carcinoma (42). We found some uniquely differentially methylated loci in our study, different from other studies so far, a possible indication of specific epigenetic marks linked with our cohort and patient geography as the epigenome is known to be dynamic and highly dependent on environmental and dietary factors (43).…”

Section: Discussioncontrasting

confidence: 99%

A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes

Krishnan

Dhas

Nair

et al. 2016

Molecular Cancer Research

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Oral tongue squamous cell carcinomas (OTSCC) are a homogenous group of aggressive tumors in the head and neck region that spread early to lymph nodes and have a higher incidence of regional failure. In addition, there is a rising incidence of oral tongue cancer in younger populations. Studies on functional DNA methylation changes linked with altered gene expression are critical for understanding the mechanisms underlying tumor development and metastasis. Such studies also provide important insight into biomarkers linked with viral infection, tumor metastasis, and patient survival in OTSCC. Therefore, we performed genome-wide methylation analysis of tumors (N ¼ 52) and correlated altered methylation with differential gene expression. The minimal tumor-specific DNA 5-methylcytosine signature identified genes near 16 different differentially methylated regions, which were validated using genomic data from The Cancer Genome Atlas cohort. In our cohort, hypermethylation of MIR10B was significantly associated with the differential expression of its target genes NR4A3 and BCL2L11 (P ¼ 0.0125 and P ¼ 0.014, respectively), which was inversely correlated with disease-free survival (P ¼ 9EÀ15 and P ¼ 2EÀ15, respectively) in patients. Finally, differential methylation in FUT3, TRIM5, TSPAN7, MAP3K8, RPS6KA2, SLC9A9, and NPAS3 genes was found to be predictive of certain clinical and epidemiologic parameters.Implications: This study reveals a functional minimal methylation profile in oral tongue tumors with associated risk habits, clinical, and epidemiologic outcomes. In addition, NR4A3 downregulation and correlation with patient survival suggests a potential target for therapeutic intervention in oral tongue tumors. Data from the current study are deposited in the NCBI Geo database (accession number GSE75540).

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Section: Discussioncontrasting

confidence: 99%

A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes

Krishnan

Dhas

Nair

et al. 2016

Molecular Cancer Research

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“…A number of dietary components were shown to interfere with epigenetic gene regulation [26][27][28] , and diet is a major factor driving the composition and metabolism of the microorganisms in the intestine. Recent studies highlight the ways in which bacterial and viral pathogens affect host epigenetic status by influencing DNA methylation and histone modification 17,29) .…”

Section: Special Issue (Mini Review) Gut Microbiota and Epigeneticsmentioning

confidence: 99%

Commensal microbiota-derived signals regulate host immune system through epigenetic modifications

Takahashi

Hase

2015

Inflammation and Regeneration

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Commensal microbiota colonizing the digestive tract is a symbiotic partner of its host, as it plays a critical role in nutrient metabolism as well as the development and maturation of the host immune system. Although it is clear that regulation of the host-commensal relationship is crucial to mammalian health, the underlying mechanisms regulating gut homeostasis are yet to be elucidated. Epigenetic modifications, including DNA methylation and histone methylation/acetylation, alter the structure of chromatin to regulate the transcriptional program of eukaryotic cells. At the whole genome level, these modifications possibly play a key role in regulating the mutually beneficial relationship between the host and the gut microbiota. In this review, we describe how the commensal microbiota and its metabolic by-products modify the epigenome of host cells, and in turn, change their development and functional behavior.Rec.2/24/2015, Acc.3/1/2015, pp129-136

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“…Within this diet, olive oil appears to reduce breast cancer risk specifically (Tsuji et al, 2012). Other aspects of the 'Mediterranean diet' have beneficial properties and may protect against other types of cancer, but are discussed thoroughly in other reviews (Egeberg et al, 2009;Taylor et al, 2009;Kabat et al, 2010;Alexander et al, 2011;Fortes and Boffetta, 2011;Fu et al, 2011;Hardy and Tollefsbol, 2011;Hauner et al, 2011;Jansen et al, 2011;Shanmugam et al, 2011;Magalhaes et al, 2012).…”

Section: Monounsaturated Fats and Olive Oilmentioning

confidence: 99%

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

Alegre¹,

Knowles²,

Robison³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Cancer prevention is rapidly emerging as a major strategy to reduce cancer mortality. In the field of breast cancer, significant strides have recently been made in the understanding of underlying preventive mechanisms. Currently, three major strategies have been linked to an increase in breast cancer risk: obesity, lack of physical exercise, and high levels of saturated dietary fat. As a result, prevention strategies for breast cancer are usually centered on these lifestyle factors. Unfortunately, there remains controversy regarding epidemiological studies that seek to determine the benefit of these lifestyle changes. We have identified crucial mechanisms that may help clarify these conflicting studies. For example, recent reports with olive oil have demonstrated that it may influence crucial transcription factors and reduce breast tumor aggressiveness by targeting HER2. Similarly, physical exercise reduces sex hormone levels, which may help protect against breast cancer. Obesity promotes tumor cell growth and cell survival through upregulation of leptin and insulin-like growth factors. This review seeks to discuss these underlying mechanisms, and more behind the three major prevention strategies, as a means of understanding how breast cancer can be prevented.

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Epigenetic diet: impact on the epigenome and cancer

Cited by 331 publications

References 213 publications

A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes

A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes

Commensal microbiota-derived signals regulate host immune system through epigenetic modifications

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

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