Epigenetic disease markers in primary sclerosing cholangitis and primary biliary cholangitis—methylomics of cholestatic liver disease
Brian D. Juran,
Bryan M. McCauley,
Elizabeth J. Atkinson
et al.
Abstract:Background:
The epigenome, the set of modifications to DNA and associated molecules that control gene expression, cellular identity, and function, plays a major role in mediating cellular responses to outside factors. Thus, evaluation of the epigenetic state can provide insights into cellular adaptions occurring over the course of disease.
Methods:
We performed epigenome-wide association studies of primary sclerosing cholangitis (PSC) and primary biliar… Show more
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