Epigenetic effects of selenium and their implications for health

Speckmann, Bodo; Grune, Tilman

doi:10.1080/15592294.2015.1013792

Cited by 118 publications

(90 citation statements)

References 86 publications

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“…Indiscriminate use of dietary Se supplements, even at doses recently considered to be safe may lead to severely affected redox status with subsequent adverse health effects, as also suggested by an increasing body of epidemiologic evidence. Moreover, Se has other effects yet uninvestigated, for example the potential of epigenetic regulation of DNA and histones [251][252][253] or interaction with the gut microbiota [254][255][256], which need to be carefully addressed. At the same time, the unclear interactions between Se and heavy metals also need clarification.…”

Section: Discussionmentioning

confidence: 99%

Selenium and Human Health: Witnessing a Copernican Revolution?

Jabłońska

Vinceti

2015

Journal of Environmental Science and Health, Part C

140

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In humans, selenium was hypothesized to lower the risk of several chronic diseases, mainly due to the antioxidant activity of selenium-containing proteins. Recent epidemiologic and laboratory Downloaded by [New York University] at 16:24 19 June 2015 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 2studies, however, are changing our perception of the biological effects of this nutritionally essential trace element. We reviewed the most recent epidemiologic and biochemical literature on selenium, synthesizing the findings from these studies into a unifying view. Randomized trials have shown that selenium did not protect against cancer and other chronic diseases, but even increased the risk of specific neoplasms such as advanced prostate cancer and skin cancer, in addition to type 2 diabetes. Biochemical studies indicate that selenium may exert a broad pattern of toxic effects at unexpectedly low concentrations. Furthermore, its upregulation of antioxidant proteins (selenium-dependent and selenium-independent) may be a manifestation of self-induced oxidative stress. In conclusion, toxic effects of selenium species occur at lower concentrations than previously believed. Those effects may include a large range of proteomic changes and adverse health effects in humans. Since the effects of environmental exposure to this element on human health still remain partially unknown, but are potentially serious, the toxicity of selenium exposure should be further investigated and considered as a public health priority.

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Section: Discussionmentioning

confidence: 99%

Selenium and Human Health: Witnessing a Copernican Revolution?

Jabłońska

Vinceti

2015

Journal of Environmental Science and Health, Part C

140

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“…Surgeon's experience the method of drug administration (root, dosage, and timing) might affect the outcomes as well (22). Moreover, it is believed that Se biology is cell-tissue dependent, complex and is affected by the disease process and it can have effects on the other metabolic pathways (15,49). The human pharmacodynamic conditions are not well-known; it is largely unknown whether genetic background of patients, their genotype and phenotype might contribute to Se distributions (22, 50).…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that trace elements such as Se might serve this goal. Selenium as an essential metabolic agent is cost effective and simple to use with antioxidant and anti-inflammatory properties (11)(12)(13)(14)(15). It is a large body of literature which indicates that the cardiac surgery is correlated with a decrease of antioxidant capacity related to a significant depletion of Se circulating levels during the CABG surgery.…”

Section: Introductionmentioning

confidence: 99%

“…During the study period, patients were observed for any adverse events, which was defined as undesirable signs or symptoms not necessary related to our intervention. If the patients showed any clinical signs of Se overdose such as, gastrointestinal disturbances, garlic smell in the exhaled air, nausea, vomiting, dizziness, pulmonary edema, and muscle cramps (15,25,26), they were excluded and immediate measurement of the Se serum level and symptomatic therapy were performed.…”

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confidence: 99%

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Effect of Selenium on Ischemia-Reperfusion Injury in the Coronary Artery Bypass Graft Surgery: A Clinical Trial Study

Sedighinejad

Imantalab

Mirmansouri

et al. 2016

Iran Red Crescent Med J

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Background: In patients with coronary artery stenosis, coronary artery bypass graft surgery (CABG) is the most effective strategy to limit infarct size and improving outcomes. However, the rapid restoring of blood flow to the tissue can paradoxically induce cardiac damage. This phenomenon termed as myocardial ischemic/reperfusion (I/R) injury which is exacerbated under cardiopulmonary bypass (CPB) and is the cause of poor clinical outcomes. Therefore, it is essential to search for novel strategies with further cardio protective effects.

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“…However, as Scly utilizes Sec as its substrate, it is possible to infer that the observed effects on metabolism could be considerably different if the selenium source of the diet was an organic form, such as selenomethionine (SeMet). SeMet is decomposed through the transsulfuration pathway into Sec (27,60), which can be utilized by Scly to provide selenium for selenoprotein synthesis (29). Nevertheless, SeMet is also incorporated nonspecifically in place of methionine (8), potentially hindering metabolic effects that are hard to distinguish.…”

Section: Obesity In the Scly Ko Mousementioning

confidence: 99%

Diet-Induced Obesity in the Selenocysteine Lyase Knockout Mouse

Seale

Gilman

Hashimoto

et al. 2015

Antioxidants & Redox Signaling

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Aims: Selenocysteine lyase (Scly) mediates selenocysteine decomposition. It was previously demonstrated that, upon adequate caloric intake (12% kcal fat) and selenium deficiency, disruption of Scly in mice leads to development of metabolic syndrome. In this study, we investigate the effect of a high-fat (45% kcal) seleniumadequate diet in Scly knockout (KO) mice on development of metabolic syndrome. Involvement of selenoproteins in energy metabolism after Scly disruption was also examined in vitro in the murine hepatoma cell line, Hepa1-6, following palmitate treatment. Results: Scly KO mice were more susceptible to diet-induced obesity than their wild-type counterparts after feeding a high-fat selenium-adequate diet. Scly KO mice had aggravated hyperinsulinemia, hypercholesterolemia, glucose, and insulin intolerance, but unchanged inflammatory cytokines and expression of most selenoproteins, except increased serum selenoprotein P (Sepp1). Scly KO mice also exhibited enhanced hepatic levels of pyruvate and enzymes involved in the regulation of pyruvate cycling, such as pyruvate carboxylase (Pcx) and pyruvate dehydrogenase (Pdh). However, in vitro silencing of Scly in Hepa1-6 cells led to diminished Sepp1 expression, and concomitant palmitate treatment decreased Pdh expression. Innovation: The role of selenium in lipid metabolism is recognized, but specific selenium-dependent mechanisms leading to obesity are unclear. This study uncovers that Scly has a remarkable effect on obesity and metabolic syndrome development triggered by high-fat exposure, independent of the expression of most selenoproteins. Conclusion: Diet-induced obesity in Scly KO mice is aggravated, with effects on pyruvate levels and consequent activation of energy metabolism independent of selenoprotein levels. Antioxid. Redox Signal. 23, 761-774.

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Epigenetic effects of selenium and their implications for health

Cited by 118 publications

References 86 publications

Selenium and Human Health: Witnessing a Copernican Revolution?

Selenium and Human Health: Witnessing a Copernican Revolution?

Effect of Selenium on Ischemia-Reperfusion Injury in the Coronary Artery Bypass Graft Surgery: A Clinical Trial Study

Diet-Induced Obesity in the Selenocysteine Lyase Knockout Mouse

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