Epigenetic Histone Modifications in the Pathogenesis of Diabetic Kidney Disease

Lu, Hongbin; Dai, Wenni; He, Liyu

doi:10.2147/dmso.s288500

Cited by 13 publications

(6 citation statements)

References 148 publications

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“…Histone methylation has monomethyl, dimethyl, and trimethyl forms, and the extent of histone methylation is known to modulate gene transcription [ 148 ] and influence DKD pathogenesis [ 155 ]. SUV39H1 is a histone methyltransferase that catalyzes methylation of the K9 residue in H3 with dimethyl or trimethyl groups.…”

Section: Epigenetic Modifications and The Pathogenesis Of Dkdmentioning

confidence: 99%

Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis

Hung

Hsu

Chen

et al. 2021

IJMS

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Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the detailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.

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Section: Epigenetic Modifications and The Pathogenesis Of Dkdmentioning

confidence: 99%

Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis

Hung

Hsu

Chen

et al. 2021

IJMS

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“…Genetic studies of DKD investigated mainly the association between genomic DNA variants (for example, single nucleotide polymorphisms, copy number variants, etc ) and clinical phenotypes of DKD in both T1DM and T2DM[ 26 ]. Epigenetic modifications (histone modifications and DNA methylation) may play a critical role in DKD as it was shown that histone acetylation and methylation are involved in the regulation of inflammation and fibrosis in DKD[ 27 ]. Epigenetics studies of DKD investigated the potentially inherited changes in gene expression that occur without changing the DNA nucleotide sequence.…”

Section: Pathophysiologymentioning

confidence: 99%

Diabetic kidney disease in pediatric patients: A current review

Muntean¹,

Stârcea²,

Banescu³

2022

WJD

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In the last decades, a significant increase in the incidence of diabetic kidney disease (DKD) was observed concomitant with rising diabetes mellitus (DM) incidence. Kidney disease associated with DM in children and adolescents is represented by persistent albuminuria, arterial hypertension, progressive decline in estimated glomerular filtration rate to end-stage renal disease and increased cardiovascular and all-cause morbidity and mortality of these conditions. In medical practice, the common and still the “gold standard” marker for prediction and detection of diabetic kidney involvement in pediatric diabetes is represented by microalbuminuria screening even if it has low specificity to detect early stages of DKD. There are some known limitations in albuminuria value as a predictor biomarker for DKD, as not all diabetic children with microalbuminuria or macroalbuminuria will develop end-stage renal disease. As tubular damage occurs before the glomerular injury, tubular biomarkers are superior to the glomerular ones. Therefore, they may serve for early detection of DKD in both type 1 DM and type 2 DM. Conventional and new biomarkers to identify diabetic children and adolescents at risk of renal complications at an early stage as well as renoprotective strategies are necessary to delay the progression of kidney disease to end-stage kidney disease. New biomarkers and therapeutic strategies are discussed as timely diagnosis and therapy are critical in the pediatric diabetic population.

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“…Epigenetics mainly involves DNA methylation, histone modification, and chromosomal remodeling, among which histone covalent modification includes methylation, acetylation, phosphorylation, and ubiquitination ( 136 – 138 ). Acetylation modifications mainly include “Reader” for specific recognition of protein lysine, “Writer” as acetyltransferase, and “Eraser” as deacetylation HDACs ( 139 , 140 ), while Sirtuin is the first discovered class III HDAC. In DKD studies, SIRT1 was involved in the phosphorylation of histone H3 ( 52 ) and the acetylation of H3K9 ( 44 , 108 ).…”

Section: Role Of the Sirtuin Family In Diabetic Kidney Diseasementioning

confidence: 99%

Sirtuin Family and Diabetic Kidney Disease

Bian

Ren

2022

Front. Endocrinol.

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Diabetes mellitus (DM) is gradually attacking the health and life of people all over the world. Diabetic kidney disease (DKD) is one of the most common chronic microvascular complications of DM, whose mechanism is complex and still lacks research. Sirtuin family is a class III histone deacetylase with highly conserved NAD+ binding domain and catalytic functional domain, while different N-terminal and C-terminal structures enable them to bind different deacetylated substrates to participate in the cellular NAD+ metabolism. The kidney is an organ rich in NAD+ and database exploration of literature shows that the Sirtuin family has different expression localization in renal, cellular, and subcellular structures. With the progress of modern technology, a variety of animal models and reagents for the Sirtuin family and DKD emerged. Machine learning in the literature shows that the Sirtuin family can regulate pathophysiological injury mainly in the glomerular filtration membrane, renal tubular absorption, and immune inflammation through various mechanisms such as epigenetics, multiple signaling pathways, and mitochondrial function. These mechanisms are the key nodes participating in DKD. Thus, it is of great significance for target therapy to study biological functions of the Sirtuin family and DKD regulation mechanism in-depth.

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Epigenetic Histone Modifications in the Pathogenesis of Diabetic Kidney Disease

Cited by 13 publications

References 148 publications

Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis

Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis

Diabetic kidney disease in pediatric patients: A current review

Sirtuin Family and Diabetic Kidney Disease

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