Epigenetic implications in maternal diabetes and metabolic syndrome‐associated risk of orofacial clefts

Sun, Bo; Reynolds, Kurt; Garland, Michael A.; McMahon, Michelle M.; Saha, Subbroto Kumar; Zhou, Chengji J.

doi:10.1002/bdr2.2226

Cited by 3 publications

(1 citation statement)

References 137 publications

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“…Specifically, MetS-related parameters, IR, dyslipidemia, and AH are contributors to systemic pathologies [18], including negative pregnancy and neonatal outcomes like heightened preeclampsia risk, altered fetal growth, and premature birth [20][21][22]. MAFLD, as the hepatic component of MetS, is associated with a high risk of adverse outcomes for both the mother and the fetus [23,24].…”

Section: Introductionmentioning

confidence: 99%

The Role of Helicobacter pylori and Metabolic Syndrome-Related Mast Cell Activation Pathologies and Their Potential Impact on Pregnancy and Neonatal Outcomes

Tzitiridou-Chatzopoulou,

Kazakos,

Orovou

et al. 2024

JCM

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Helicobacter pylori infection, a significant global burden beyond the gastrointestinal tract, has long been implicated in various systemic pathologies. Rising evidence suggests that the bacterium’s intricate relationship with the immune system and its potential to induce chronic inflammation impact diverse pathophysiological processes in pregnant women that may in turn affect the incidence of several adverse pregnancy and neonate outcomes. Helicobacter pylori infection, which has been linked to metabolic syndrome and other disorders by provoking pericyte dysfunction, hyperhomocysteinemia, galectin-3, atrial fibrillation, gut dysbiosis, and mast cell activation pathologies, may also contribute to adverse pregnancy and neonatal outcomes. Together with increasing our biological understanding of the individual and collective involvement of Helicobacter pylori infection-related metabolic syndrome and concurrent activation of mast cells in maternal, fetus, and neonatal health outcomes, the present narrative review may foster related research endeavors to offer novel therapeutic approaches and informed clinical practice interventions to mitigate relevant risks of this critical topic among pregnant women and their offspring.

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Section: Introductionmentioning

confidence: 99%

The Role of Helicobacter pylori and Metabolic Syndrome-Related Mast Cell Activation Pathologies and Their Potential Impact on Pregnancy and Neonatal Outcomes

Tzitiridou-Chatzopoulou,

Kazakos,

Orovou

et al. 2024

JCM

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Maternal Metabolic Status and Orofacial Cleft Risk: A Case-Control Study in Thailand

Pisek,

McKinney,

Muktabhant

et al. 2024

International Dental Journal

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Maternal factors increase risk of orofacial cleft: a meta-analysis

Ács,

Cavalcante,

Bănărescu

et al. 2024

Sci Rep

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Orofacial clefts are among the most prevalent birth defects, with severe medical and psychosocial consequences. Cleft lip with or without cleft palate (CL ± P) and cleft palate only (CPO) affect on average nearly 1/700 births worldwide. The cause of most non-syndromic cases is unknown. Maternal factors and disorders are assumed to modify the risk of orofacial clefting. In the present study, we performed a systematic review and meta-analysis to analyze the effects of maternal underweight, obesity, hypertension, diabetes, as well as smoking, and alcohol consumption on the development of orofacial clefts. As CL ± CP and CPO have distinct pathogenetic backgrounds, these cleft subtypes were assessed separately. Altogether, 5,830 studies were identified and 64 of them met the inclusion and exclusion criteria. Obesity significantly elevated the odds of clefting (OR = 1.28, CI:1.08–1.51) (ORCL±CP = 1.23, CI:1.01–1.50; ORCPO = 1.31, CI:0.97–1.77). Maternal underweight also significantly increased the odds of clefting (OR = 1.21 CI:1.06–1.38). In mothers with type 1 diabetes, the odds of cleft development were significantly elevated (OR = 1,75, CI:1.45–2.12). Essential hypertension was also associated with higher odds of developing cleft (OR = 1.55, CI:1.18–2.03). Smoking during pregnancy significantly elevated the odds of cleft development (OR = 1.55, CI:1.34–1.79) (ORCL±CP = 1.58, CI:1.36–1.83; ORCPO = 1.50, CI:1.15–1.96). Passive smoking was even more damaging than active tobacco use, but alcohol consumption had no effect. In conclusion, this study clearly showed the importance of maintaining normal maternal body weight and emphasized the importance of hypertension and type 1 diabetes care in the first months of pregnancy. It also highlighted similarnegative effects of passive and active smoking, while alcohol consumption did not seem to be a significant risk factor for cleft development. However, there is a complete lack of available studies on the interactions of these factors, which is an essential direction for improving prevention.

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Epigenetic implications in maternal diabetes and metabolic syndrome‐associated risk of orofacial clefts

Cited by 3 publications

References 137 publications

The Role of Helicobacter pylori and Metabolic Syndrome-Related Mast Cell Activation Pathologies and Their Potential Impact on Pregnancy and Neonatal Outcomes

The Role of Helicobacter pylori and Metabolic Syndrome-Related Mast Cell Activation Pathologies and Their Potential Impact on Pregnancy and Neonatal Outcomes

Maternal Metabolic Status and Orofacial Cleft Risk: A Case-Control Study in Thailand

Maternal factors increase risk of orofacial cleft: a meta-analysis

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