Epigenetic inactivation of the E-cadherin gene in eyelid sebaceous gland carcinoma

Abstract

Epigenetic inactivation of the E-cadherin gene causes loss of membrane-bound E-cadherin and could contribute to the reduced disease-free survival in eyelid sebaceous gland carcinoma. Mutations in the β-catenin gene do not seem to be involved in the pathogenesis of eyelid sebaceous gland carcinoma.

miRNA-200c and miRNA-141 as potential prognostic biomarkers and regulators of epithelial-mesenchymal transition in eyelid sebaceous gland carcinoma

“…The role of EMT regulators ZEB2 and E-cadherin proteins in eyelid SGC has been reported earlier, where overexpression of ZEB2 and loss of E-cadherin was associated with poor prognosis 13. E-cadherin gene silencing by promoter hypermethylation has also been reported in ocular SGC 14. The present study was designed to determine the status and prognostic significance of miRNA-200c and miRNA-141 in eyelid SGC, and to correlate with clinicopathological high-risk features.…”

ZEB2/SIP1 as novel prognostic indicator in eyelid sebaceous gland carcinoma

“…E-cadherin gene silencing by promoter hypermethylation in 72% of cases has been earlier reported in ocular SGC [15]. Mutations in the E-cadherin gene may also contribute to the loss of E-cadherin.…”

“…E-cadherin loss and its promoter hypermethylation status have been earlier reported in eyelid SGC; however, its role in EMT remains to be explored [15]. The present study was, therefore, designed to evaluate the status of EMT regulators ZEB2 and E-cadherin in SGC of the eyelid.…”

Sebaceous Carcinoma of the Eyelid

“…50,54 Adhesion Protein Expression and Epithelial Mesenchymal Transition-Related Markers: Similar to other types of aggressive carcinomas, such as lobular carcinoma of the breast, PSC (in particular, poorly differentiated PSC) has been shown to disrupt the intercellular and cell stroma adhesion machinery with loss or diminished membranous E-cadherin and beta-catenin protein expression in 53% to 83% and 56% to 61% of cases, respectively. 55,56 Loss or diminished expression of these markers was correlated with the presence of the epigenetic promoter methylation of CDH1 (16q22.1). 55 Similarly, PSC also appears to overexpress ZEB2 in up to 68% of cases.…”