Epigenetic inheritance across multiple generations

Thamban, Thushara; Agarwaal, Viplove; Basu, Amitava; Rajeev, Ramisetti; Sinha, Anunay; Dwivedi, Ambey Prasad; Khosla, Sanjeev

doi:10.1016/b978-0-12-816363-4.00019-5

Cited by 4 publications

(2 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Examples of such methylation‐based regulatory mechanisms include reversible marking of boundaries between euchromatin and heterochromatin at m CHH (H = A, C, T) sites mediated by small interfering RNA (siRNA) (Khraiwesh et al., 2012; Li et al., 2015; Roudier et al., 2009), changes in the expression state of epialleles mediated by repeat sequences near the affected gene (Weigel & Colot, 2012), or methyltransferase enzymes that transfer or de novo create methylation marks at CpG, CpHpH or CpNpG (N = A, C, G, T) sites (Cao & Jacobsen, 2002). These mechanisms play a role in phenotypic plasticity (Nicotra et al., 2010) and stress‐related adaptation in plants (Boyko & Kovalchuk, 2008) and can be transmitted to the next generation (Henderson & Jacobsen, 2007; Jablonka & Raz, 2009; Thamban et al., 2019; Verhoeven & van Gurp, 2012). The involvement of epigenetic regulation in ecological and evolutionary responses could resolve the paradox of rapid local phenotypic differentiation in invasive plant species with limited genetic variation and a short time since introduction (Richards et al., 2012; Schrieber & Lachmuth, 2017).…”

Section: Introductionmentioning

confidence: 99%

Manipulation of cytosine methylation does not remove latitudinal clines in two invasive goldenrod species in Central Europe

et al. 2020

View full text Add to dashboard Cite

Invasive species frequently differentiate phenotypically in novel environments within a few generations, often even with limited genetic variation. For the invasive plants Solidago canadensis and S. gigantea, we tested whether such differentiation might have occurred through heritable epigenetic changes in cytosine methylation. In a 2-year common-garden experiment, we grew plants from seeds collected along a latitudinal gradient in their non-native Central European range to test for trait differentiation and whether differentiation disappeared when seeds were treated with the demethylation agent zebularine. Microsatellite markers revealed no population structure along the latitudinal gradient in S. canadensis, but three genetic clusters in S. gigantea. Solidago canadensis showed latitudinal clines in flowering phenology and growth. In S. gigantea, the number of clonal offspring decreased with latitude. Although zebularine had a significant effect on early growth, probably through effects on cytosine methylation, latitudinal clines remained (or even got stronger) in plants raised from seeds treated with zebularine. Thus, our experiment provides no evidence that epigenetic mechanisms by selective cytosine methylation contribute to the observed phenotypic differentiation in invasive goldenrods in Central Europe. K E Y W O R D S common-garden experiment, epigenetic variation, microsatellites, Solidago canadensis, Solidago gigantea, zebularine This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

show abstract

Section: Introductionmentioning

confidence: 99%

Manipulation of cytosine methylation does not remove latitudinal clines in two invasive goldenrod species in Central Europe

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Studies on various model organisms have revealed that in addition to inheritance of DNA and histone modifications, small non-coding RNAs such as siRNAs, miRNAs, and piRNAs also form vectors for inheritance of acquired non-genetic information [9, 10]. piRNAs and Piwi proteins are associated with the protection of the genome in the germline from transposable elements and have been shown to be inherited and inducer of transgenerational epigenetic silencing[11, 12].…”

Section: Introductionmentioning

confidence: 99%

DNMT3L interacts with Piwi and modulates the expression of piRNAs

Rajeev,

Mishra,

Khosla

2023

Preprint

Self Cite

View full text Add to dashboard Cite

The epigenetic modulator, DNMT3L, has been shown to be involved in nuclear reprogramming. Previous work from our laboratory had shown the accumulation and inheritance of epimutations across multiple generations when DNMT3L was ectopically expressed in transgenic DNMT3L Drosophila. Here, we show interaction of DNMT3L with Piwi, a member of a family of proteins known to perform their function through their association with piRNAs. Importantly, DNMT3L expression caused a significant alteration in the piRNA profile across multiple generations in transgenic Drosophila. As piRNAs are known to be passed on from one generation to another, we believe that the DNMT3L through its interaction with Piwi act to modify the inherited pool of piRNAs, which in turn allows accumulation of aberrant epigenetic modifications in subsequent generation. Furthermore, we show the interaction of DNMT3L with Histone H1, a non-core histone involved in higher order chromatin organisation. In light of these observations, it is proposed that in addition to its role in modulating core histone modifications, DNMT3L allows for inheritance of non-genetic information through its collaboration with Piwi, piRNAs and histone H1.

show abstract

Ecotoxicological epigenetics in invertebrates: Emerging tool for the evaluation of present and past pollution burden

Šrut

2021

Chemosphere

View full text Add to dashboard Cite

Epigenetic inheritance across multiple generations

Cited by 4 publications

References 113 publications

Manipulation of cytosine methylation does not remove latitudinal clines in two invasive goldenrod species in Central Europe

Manipulation of cytosine methylation does not remove latitudinal clines in two invasive goldenrod species in Central Europe

DNMT3L interacts with Piwi and modulates the expression of piRNAs

Ecotoxicological epigenetics in invertebrates: Emerging tool for the evaluation of present and past pollution burden

Contact Info

Product

Resources

About