2024
DOI: 10.1038/s41586-024-07472-3
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Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs

A. Tomar,
M. Gomez-Velazquez,
R. Gerlini
et al.

Abstract: Spermatozoa harbour a complex and environment-sensitive pool of small non-coding RNAs (sncRNAs)1, which influences offspring development and adult phenotypes1–7. Whether spermatozoa in the epididymis are directly susceptible to environmental cues is not fully understood8. Here we used two distinct paradigms of preconception acute high-fat diet to dissect epididymal versus testicular contributions to the sperm sncRNA pool and offspring health. We show that epididymal spermatozoa, but not developing germ cells, … Show more

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Cited by 23 publications
(1 citation statement)
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“…A recent study from Tomar and colleagues adds a significant chapter to our understanding of both the breadth and impact epigenetic influences borne by sperm in mice and humans [1]. By tracking the origins and fate of mitochondrial tRNAs and their fragments (mt-tRNAs), this insightful and groundbreaking work links paternal health status at the time of conception to alterations in offspring metabolism via dietary inputs borne by sperm that materialize in an experimentally demonstrable fashion at the time of fertilization.…”
mentioning
confidence: 99%
“…A recent study from Tomar and colleagues adds a significant chapter to our understanding of both the breadth and impact epigenetic influences borne by sperm in mice and humans [1]. By tracking the origins and fate of mitochondrial tRNAs and their fragments (mt-tRNAs), this insightful and groundbreaking work links paternal health status at the time of conception to alterations in offspring metabolism via dietary inputs borne by sperm that materialize in an experimentally demonstrable fashion at the time of fertilization.…”
mentioning
confidence: 99%