Epigenetic markers of exposure to polycyclic aromatic hydrocarbons in Mexican brickmakers: A pilot study

Alegría-Torres, Jorge Alejandro; Barretta, Francesco; Batres-Esquivel, Lilia E.; Carrizales-Yáñez, Leticia; Pérez-Maldonado, Iván N.; Baccarelli, Andrea; Bertazzi, Pier Alberto

doi:10.1016/j.chemosphere.2012.11.077

Cited by 49 publications

(32 citation statements)

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“…139 Diesel exhaust particle exposure (DEP) has been associated with DNA methylation changes in peripheral blood 144 and lung epithelial cells. 145 DNA methylation in adults 146 and children both as a result of direct 147 and in utero 148, 149 exposure is also influenced by PAHs, a bi-product of incomplete combustion of organic materials in airborne pollution. In children, PAH exposure has been associated with increased methylation of IFNG 148 and the T reg transcription factor FOXP3 as well as impaired T reg function.…”

Section: Epigenetic Changes Associated With Exposure To Air Pollutionmentioning

confidence: 99%

The environment, epigenome, and asthma

Yang

Lozupone

Schwartz

2017

Journal of Allergy and Clinical Immunology

132

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Asthma prevalence has been on the increase, especially in North America compared to other continents. However, the prevalence of asthma differs worldwide and in many countries the prevalence of asthma is stable or decreasing. This highlights the influence of environmental exposures, such as allergens, air pollution, and environmental microbiome, on disease etiology and pathogenesis. The epigenome may provide the unifying mechanism that translates the influence of environmental exposures to changes in gene expression, respiratory epithelial function, and immune cell skewing that are hallmarks of asthma. In this review, we will introduce the concept of the environmental epigenome in asthma, summarize previous publications of relevance to this field, and discuss future directions.

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Section: Epigenetic Changes Associated With Exposure To Air Pollutionmentioning

confidence: 99%

The environment, epigenome, and asthma

Yang

Lozupone

Schwartz

2017

Journal of Allergy and Clinical Immunology

132

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“…Recently, an increasing number of scientific investigations have demonstrated that epigenetic alterations play an important role in the onset, establishment, and development of adverse health outcomes associated with environmental exposures (Marsit, 2015;Hodjat et al, 2017;Sun et al, 2018), including CVD (Alegría-Torres et al, 2013;Perez-Vazquez et al, 2017;Sun et al, 2018). Epigenetic changes include DNA methylation, non-coding RNAs (such as microRNAs), chromatin remodeling, and histone modifications (Tammen et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Expression levels of circulating microRNAs‐126, ‐155, and ‐145 in Mexican women exposed to polycyclic aromatic hydrocarbons through biomass fuel use

Ruíz-Vera

Ochoa-Martínez

Pruneda-Álvarez

et al. 2019

Environ and Mol Mutagen

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Human exposure to polycyclic aromatic hydrocarbons (PAHs) has been considered a risk determinant for the development of cardiovascular diseases (CVD). Therefore, the aim of this study was to assess expression levels of vascular‐related miRNAs, miR‐126, miR‐155, and miR‐145, in plasma from women (aged 19–81 years) exposed (n = 100) and non‐exposed (n = 20) to PAHs via biomass combustion smoke.1‐hydroxypyrene (1‐OHP) was determined in urine as a biomarker of exposure to PAHs using high‐resolution liquid chromatography. Plasma expression levels of proposed miRNAs were determined by quantitative real‐time PCR. Additionally, traditional risk factors (age, blood pressure, serum lipid profile, blood glucose, and among others) associated with CVD were evaluated. Urinary 1‐OHP concentrations and plasma expression levels of miR‐126 and miR‐155 were significantly higher (P < 0.05) in women using wood as a fuel source in their homes (indoor) compared to women from the reference group (non‐exposed to biomass smoke). Besides, multivariate linear regression analyses revealed that miR‐126[β = 0.61; 95% confidence interval (0.32–0.90)] and miR‐155 [β = 0.45; 95% confidence interval (0.13–0.84)] expression levels were significantly associated with urinary 1‐OHP concentrations after being adjusted by traditional risk factors (P < 0.05). In contrast, no significant relationship was found between miR‐145 and urinary 1‐OHP levels. Furthermore, miRNAs assessed in this investigation are associated with CVD events. Consequently, actions to reduce exposure to PAHs in the evaluated population are warranted. Environ. Mol. Mutagen. 60:546–558, 2019. © 2019 Wiley Periodicals, Inc.

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“…Kile et al (2013) pyrosequenced NOS2 and repetitive elements in the blood from 38 welders, finding PM 2.5 associations with NOS2 but not with repeats [19]. Alegria-Torres et al (2013) pyrosequenced several genes in the blood from 39 male brick manufacturers, finding associations with polycyclic aromatic hydrocarbons (measured in urine) and DNA methylation of loci mapped to IL12, TNFA, p53, and Alu repeats [17]; note that IL12 and TNFA reflect immune response. Tarantini et al (2013) pyrosequenced several targets in the blood from 63 steel workers, studying association between DNA methylation and particulate matter assumed to be rich in metals [23].…”

Section: Environmental Exposuresmentioning

confidence: 99%

“…Because access to blood specimens is typically much more convenient to obtain from human subjects, the bulk of published studies have used whole blood (sometimes referred to as peripheral blood). A wide variety of phenotypes and health conditions have been studied: aging [4][5][6][7][8], cancer [9][10][11][12], obesity [5,13], cardiovascular disease [14], prenatal exposures/perinatal outcomes [15,16], environmental exposures [17][18][19][20][21][22][23][24] (tobacco in particular [25,26]), inflammatory diseases [27, 28•], psychiatric conditions [21,[29][30][31][32], and fertility [33]. While many of these studies have used candidate gene approaches with bisulfite-pyrosequencing, an increasing number have conducted epigenome-wide association studies (EWAS) using commercially available microarrays such as the Infinium HumanMethylation450 BeadChip assay ("450K," produced by Illumina, Inc.), its predecessor, the Infinium HumanMethylation27 BeadChip ("27K"), or an This article is part of the Topical Collection on Environmental Epigenetics older Illumina product based on the company's GoldenGate product.…”

Section: Introductionmentioning

confidence: 99%

DNA Methylation in Whole Blood: Uses and Challenges

Houseman

Kim

Kelsey

et al. 2015

Curr Envir Health Rpt

119

105

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Due to its convenience, the blood is commonly used in epigenomic studies, but its heterogeneous nature leads to interpretation difficulties, given the now widely recognized potential for confounding by cell composition effects. Many recent publications have reported significant associations between DNA methylation and a variety of health conditions or exposures. In this review, we summarize many of these recent publications, highlighting the findings in the context of potential cell composition effects, particularly findings that are indicative of immune response or inflammation. While there is substantial evidence for confounding by cell composition, there is nevertheless also evidence for differential DNA methylation suggestive of processes that are not cell mediated. We conclude that important biological insights still may be gained from studying DNA methylation in whole blood, either by investigating the cell composition effects themselves or processes that demonstrate associations even after adjusting for cell composition effects.

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Epigenetic markers of exposure to polycyclic aromatic hydrocarbons in Mexican brickmakers: A pilot study

Cited by 49 publications

References 50 publications

The environment, epigenome, and asthma

The environment, epigenome, and asthma

Expression levels of circulating microRNAs‐126, ‐155, and ‐145 in Mexican women exposed to polycyclic aromatic hydrocarbons through biomass fuel use

DNA Methylation in Whole Blood: Uses and Challenges

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