2011
DOI: 10.1017/s0954422411000102
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Epigenetic mechanisms elicited by nutrition in early life

Abstract: A growing number of studies focusing on the developmental origin of health and disease hypothesis have identified links among early nutrition, epigenetic processes and diseases also in later life. Different epigenetic mechanisms are elicited by dietary factors in early critical developmental ages that are able to affect the susceptibility to several diseases in adulthood. The studies here reviewed suggest that maternal and neonatal diet may have long-lasting effects in the development of non-communicable chron… Show more

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Cited by 202 publications
(121 citation statements)
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“…Such changes in gut permeability might become more important as the individual matures since large molecules such as antibodies, leptin, and insulin cross the neonatal intestinal barrier and enter the circulation (287,349). Regardless of the specific mechanism, early postnatal nutrition and milk content might alter gut microbiota as an explanation for the increased obesity of diet-resistant pups cross-fostered to obese DIO dams (75,176,272,315).…”
Section: Gut Microbiotamentioning
confidence: 99%
“…Such changes in gut permeability might become more important as the individual matures since large molecules such as antibodies, leptin, and insulin cross the neonatal intestinal barrier and enter the circulation (287,349). Regardless of the specific mechanism, early postnatal nutrition and milk content might alter gut microbiota as an explanation for the increased obesity of diet-resistant pups cross-fostered to obese DIO dams (75,176,272,315).…”
Section: Gut Microbiotamentioning
confidence: 99%
“…10,11 Such plasticity permits a range of phenotypes to develop from a single genotype and is finalized to allow the organism to match its environment. 12 The evidence for invoking developmental plasticity as a biological property, which may influence the risk of disease, stems from numerous studies in animals in which dietary or endocrine challenges at various times from conception until weaning have been shown to induce persistent changes in cardiovascular and metabolic function in the offspring.…”
Section: The Mechanisms Of Programmingmentioning
confidence: 99%
“…The GC analysis of FAs profi le revealed that the designed bars, owing to milk fat contribution in their formulation, contained signifi cant quantities of SCSFAs (14.03 g/ 100 g FA on average). These acids are known for their very benefi cial properties to young organisms [Canani et al, 2011]. They are utilized in the body as an energetic fuel for muscles, heart, liver and kidneys.…”
Section: Discussionmentioning
confidence: 99%