Epigenetic mechanisms of nicotine dependence

Muenstermann, Caspar; Clemens, Kelly J.

doi:10.1016/j.neubiorev.2023.105505

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2024

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Cited by 9 publications

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“…Secondly, personalized precision therapies tailored to individual genetic profiles emerge as imperative for effective intervention. Accumulating evidence supports a role for epigenetics (DNA methylation; Histone acetylation; Histone methylation) in the development and maintenance of nicotine dependence to many drugs of abuse [ 139 , 140 ]. As more powerful sequence detection tools are developed, including analysis of common, low-frequency, and rare variants, as well as incorporating or complementing familial and environmental risk factors, this will provide even better risk stratification, unlocking the full potential of personalized treatment.…”

Section: Discussionmentioning

confidence: 99%