Epigenetic modulation of mechanisms involved in inflammation: Influence of selected polyphenolic substances on histone acetylation state

Kiss, Anna K.; Granica, Sebastian; Stolarczyk, Magdalena; Melzig, Matthias F.

doi:10.1016/j.foodchem.2011.09.109

Cited by 43 publications

(26 citation statements)

References 24 publications

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“…86 Metabolites of ellagitannins, ellagic acid and the bacterial metabolites, urolithin B and C, also act as epigenetic modulators. At physiologic concentrations, ellagic acid and urolithins reduced HAT activity in a tumor necrosis factor (TNF) stimulated monocyte cell line 82 suggesting a plausible epigenetic mechanism mediated through gut microbial metabolites that is consistent with the observations that ellagitannins are an anti-inflammatory component of diet.…”

Section: Ellagitanninssupporting

confidence: 77%

“…76, 77 This mechanism is mediated by altering the availability of methyl groups that are used to methylate catechol groups on polyphenols by catecohol-O-methyltransferase (EC 2.1.16). Additionally, the microbial metabolites of EGCG, gallic acid (GA) and epigallocatechin (EGC) influence epigenetic gene expression by acting as HAT inhibitors 78-82 although not as strongly as EGCG. 82 …”

Section: Egcgmentioning

confidence: 99%

“…Additionally, the microbial metabolites of EGCG, gallic acid (GA) and epigallocatechin (EGC) influence epigenetic gene expression by acting as HAT inhibitors 78-82 although not as strongly as EGCG. 82 …”

Section: Egcgmentioning

confidence: 99%

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Diet, the Gut Microbiome, and Epigenetics

Hullar

Fu²

2014

The Cancer Journal

173

116

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Increasingly, the gut microbiome is implicated in the etiology of cancer, not only as an infectious agent, but also by altering exposure to dietary compounds that influence disease risk. While the composition and metabolism of the gut microbiome is influenced by diet, the gut microbiome can also modify dietary exposures in ways that are beneficial or detrimental to the human host. The colonic bacteria metabolize macronutrients, either as specialists or in consortia of bacteria, in a variety of diverse metabolic pathways. Microbial metabolites of diet can also be epigenetic activators of gene expression that may influence cancer risk in humans. Epigenetic involves heritable changes in gene expression via post translational and post transcriptional modifications. Microbial metabolites can influence epigenetics by altering the pool of compounds used for modification or by directly inhibiting enzymes involved in epigenetic pathways. Colonic epithelium is immediately exposed to these metabolites, although some metabolites are also found in systemic circulation. In this review, we discuss the role of the gut microbiome in dietary metabolism and how microbial metabolites may influence gene expression linked to colon cancer risk.

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Section: Ellagitanninssupporting

confidence: 77%

Section: Egcgmentioning

confidence: 99%

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Diet, the Gut Microbiome, and Epigenetics

Hullar

Fu²

2014

The Cancer Journal

173

116

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“…Oenothein B and valoneic acid dilactone isolated from the herb of Epilobium angustifolium L. were investigated for their influence on histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity, which play a role in inflammation. Thereby, oenothein B restored cell viability and reversed the effect of TNF-α on HAT and HDAC activities (Kiss et al, 2012). The flavonoid myricetin 3- O -β-D-glucuronide, isolated from the leaves of Epilobium angustifolium, exhibited anti-inflammatory activity on carrageenan-induced edema in the rat hind paw and an inhibitory effect on prostaglandin biosynthesis (Hiermann et al, 1991).…”

Section: Resultsmentioning

confidence: 99%

Ethnopharmacological in vitro studies on Austria's folk medicine—An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs

Vogl

Picker

Mihály-Bison

et al. 2013

Journal of Ethnopharmacology

225

130

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Ethnopharmacological relevanceIn Austria, like in most Western countries, knowledge about traditional medicinal plants is becoming scarce. Searching the literature concerning Austria's ethnomedicine reveals its scant scientific exploration.Aiming to substantiate the potential of medicinal plants traditionally used in Austria, 63 plant species or genera with claimed anti-inflammatory properties listed in the VOLKSMED database were assessed for their in vitro anti-inflammatory activity.Material and methods71 herbal drugs from 63 plant species or genera were extracted using solvents of varying polarities and subsequently depleted from the bulk constituents, chlorophylls and tannins to avoid possible interferences with the assays. The obtained 257 extracts were assessed for their in vitro anti-inflammatory activity. The expression of the inflammatory mediators E-selectin and interleukin-8 (IL-8), induced by the inflammatory stimuli tumor necrosis factor alpha (TNF-α) and the bacterial product lipopolysaccharide (LPS) was measured in endothelial cells. The potential of the extracts to activate the nuclear factors PPARα and PPARγ and to inhibit TNF-α-induced activation of the nuclear factor-kappa B (NF-κB) in HEK293 cells was determined by luciferase reporter gene assays.ResultsIn total, extracts from 67 of the 71 assessed herbal drugs revealed anti-inflammatory activity in the applied in vitro test systems. Thereby, 30 could downregulate E-selectin or IL-8 gene expression, 28 were strong activators of PPARα or PPARγ (inducing activation of more than 2-fold at a concentration of 10 µg/mL) and 21 evoked a strong inhibition of NF-κB (inhibition of more than 80% at 10 µg/mL).ConclusionOur research supports the efficacy of herbal drugs reported in Austrian folk medicine used for ailments associated with inflammatory processes. Hence, an ethnopharmacological screening approach is a useful tool for the discovery of new drug leads.

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“…Additionally, the stilbene resveratrol has been demonstrated to target the class III HDAC Sirt1, the HAT p300, and non-coding RNA expression (156–158). Unlike other polyphenol metabolites, ellagic acid does not affect HDAC activity, but rather has been shown to decrease HAT activity in TNF-stimulated THP-1 cells (159). The polyphenol metabolites ECGC and flavonoids (catechin and quercetin) and the isothiocyanate sulforaphane have been demonstrated to inhibit DNMTs (160–162).…”

Section: Regulation Of Chromatin Modification By Endogenous Metabolitmentioning

confidence: 99%

Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin

Krautkramer

Dhillon

Denu

et al. 2017

Translational Research

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The mammalian gut microbiota has been linked to host developmental, immunologic, and metabolic outcomes. This collection of trillions of microbes inhabits the gut and produces a myriad of metabolites, which are measurable in host circulation and contribute to the pathogenesis of human diseases. The link between endogenous metabolite availability and chromatin regulation is a well-established and active area of investigation, however, whether microbial metabolites can elicit similar effects is less understood. In this review, we focus on seminal and recent research that establishes chromatin regulatory roles for both endogenous and microbial metabolites. We also highlight key physiologic and disease settings where microbial metabolite-host chromatin interactions have been established and/or may be pertinent.

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Epigenetic modulation of mechanisms involved in inflammation: Influence of selected polyphenolic substances on histone acetylation state

Cited by 43 publications

References 24 publications

Diet, the Gut Microbiome, and Epigenetics

Diet, the Gut Microbiome, and Epigenetics

Ethnopharmacological in vitro studies on Austria's folk medicine—An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs

Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin

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