Epigenetic modulators of thyroid cancer

Rodríguez-Rodero, Sandra; Delgado, Elías; Díaz-Naya, Lucia; Martín-Nieto, Alicia; Torre, Edelmiro Menéndez

doi:10.1016/j.endinu.2016.09.006

Cited by 19 publications

(17 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most often upregulated miRNAs in PC are miR-146b, miR-222, miR-221 and miR-181b. Overexpressed miR-146b targets retinoic acid receptor beta (RARβ) and reduces expression of this gene leading to increased tumour aggressiveness and extrathyroidal invasion [117][118][119][120].…”

Section: Mirnas In Thyroid Tumoursmentioning

confidence: 99%

“…Reduced expression of p27 results in increased proliferation of tumour cells. These processes are related to aggressive behaviour of tumour, extrathyroidal invasion and spread to lymph nodes [117][118][119][120]. MiR-181b is also overexpressed in PC compared to normal thyroid tissue.…”

Section: Mirnas In Thyroid Tumoursmentioning

confidence: 99%

“…MiR-451 functions as a tumour suppressor by targeting the PI3/AKT pathway. Downregulation of miR-451a is associated with aggressive tumour course and the presence of extrathyroidal invasion [118,120]. In PC, miR-613 is involved in cell proliferation and invasion [117,118], but downregulated miR-137 leads to increased cellular proliferation, invasion and migration [118].…”

Section: Mirnas In Thyroid Tumoursmentioning

confidence: 99%

“…The miRNAs found in FC are also frequently present in other subtypes of thyroid cancer [120]. MiR-199a-5p is downregulated, but miR-197 and miR-346 are upregulated in FC resulting in increased cancer cell proliferation [118].…”

Section: Mirnas In Thyroid Tumoursmentioning

confidence: 99%

“…Loss of miR-200 expression in anaplastic carcinoma results in EMT that represses the epithelial features of cancer cells and disrupts the cell-cell adhesion mediated by loss of E-cadherin. This process enables cells to migrate and invade [116,118,120].…”

Section: Mirnas In Thyroid Tumoursmentioning

confidence: 99%

See 4 more Smart Citations

Thyroid Nodules in Diagnostic Pathology: From Classic Concepts to Innovations

Fridrihsone¹,

Štrumfa²,

Strumfs³

et al. 2018

Histopathology - An Update

View full text Add to dashboard Cite

Thyroid nodules are frequent in general population, found in 3.7-7% of people by palpation and 42-67% by ultrasonography (US). The differential diagnosis ranges from papillary (PC), follicular (FC) and medullary (MC) carcinomas to follicular adenoma (FA) and colloid goitre. Cancer risk in thyroid nodules varies: 5% in masses found by palpation, 1.6-15% by US, 3.9-11.3% by computed tomography (CT), 5-6% by magnetic resonance imaging (MRI) and 30-50% by positron emission tomography (PET). The final diagnosis depends on fine needle aspiration (FNA) findings and histopathology. The recent WHO classification (2017) is based on classic morphology, including assessment of invasion and nuclei. New entities are defined to designate tumours with doubtful invasion or controversial nuclear features. By immunohistochemistry, PC expresses HBME-1, TROP-2, CITED1 and CK19. Notably, PC can stain for CD20. MC is recognised by neuroendocrine differentiation. To distinguish FA vs. FC, evaluation of HBME-1, p27 and galectin has been suggested. Regarding miRNAs, miR-146b, miR-222, miR-221 and miR-181b are upregulated, while miR-145, miR-451, miR-613 and miR-137 are downregulated in PC. FC features downregulated miR-199a-5p and upregulated miR-197 and miR-346. In MC, miR-21 and miR-129-5p are downregulated. In addition, increased systemic inflammatory reaction can be poor prognostic factor in thyroid cancer. The aim of this chapter is to review classic and innovative histopathology of thyroid nodules for diagnostic pathology practice and research in multidisciplinary thyroid teams.

show abstract

Section: Mirnas In Thyroid Tumoursmentioning

confidence: 99%

Section: Mirnas In Thyroid Tumoursmentioning

confidence: 99%

Section: Mirnas In Thyroid Tumoursmentioning

confidence: 99%

Section: Mirnas In Thyroid Tumoursmentioning

confidence: 99%

Section: Mirnas In Thyroid Tumoursmentioning

confidence: 99%

See 3 more Smart Citations

Thyroid Nodules in Diagnostic Pathology: From Classic Concepts to Innovations

Fridrihsone¹,

Štrumfa²,

Strumfs³

et al. 2018

Histopathology - An Update

View full text Add to dashboard Cite

show abstract

Epigenetic signatures in cardiac fibrosis, special emphasis on DNA methylation and histone modification

et al. 2018

View full text Add to dashboard Cite

Cardiac fibrosis is defined as excess deposition of extracellular matrix (ECM), resulting in tissue scarring and organ dysfunction. In recent years, despite the underlying mechanisms of cardiac fibrosis are still unknown, numerous studies suggest that epigenetic regulation of cardiac fibrosis. Cardiac fibrosis is regulated by a myriad of factors that converge on the transcription of genes encoding extracellular matrix protein, a process the epigenetic machinery plays a pivotal role. Epigenetic modifications contain three main processes: DNA methylation, histone modifications, and noncoding RNAs. Here, we review recent studies that have illustrated key roles for epigenetic events in the control of pro-fibrotic gene expression, and highlight the potential of molecule mechanisms that target epigenetic regulators as a means of treating cardiac fibrosis.

show abstract