Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer

Selmin, Ornella I.; Donovan, Micah G.; Stillwater, Barbara; Neumayer, Leigh; Romagnolo, Donato F.

doi:10.3389/fnut.2020.00159

Cited by 10 publications

(5 citation statements)

References 117 publications

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“…Song et al [ 344 ] demonstrated the anti-angiogenic effect of CAPE in a chick embryo chorioallantoic membrane (CAM) assay system. CAPE also suppressed VEGF secretion by MDA-MB-231 cells and the development of capillary-like tubes by endothelial cells, further indicating its anti-angiogenic potential [ 345 , 346 , 347 , 348 ]. Similarly, Izuta et al [ 347 ] reported that CAPE inhibits VEGF expression in human umbilical vein endothelial cells (HUVECs).…”

Section: Antitumor Activity Of Propolis and Its Polyphenolic/flavonoi...mentioning

confidence: 99%

“…In addition, P10.EE reduced total biomass and proliferation of human brain-microvascular endothelial cells and reduced vessel sprouting in the CAM assay. The effects of Chinese red propolis and its related products on VEGF-induced proliferation and migration of HUVECs were also investigated [ 345 , 346 , 347 , 348 ]. Chinese red propolis inhibited both VEGF-induced HUVEC proliferation and migration.…”

Section: Antitumor Activity Of Propolis and Its Polyphenolic/flavonoi...mentioning

confidence: 99%

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Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Oršolić

Jembrek

2022

IJMS

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In recent years, interest in natural products such as alternative sources of pharmaceuticals for numerous chronic diseases, including tumors, has been renewed. Propolis, a natural product collected by honeybees, and polyphenolic/flavonoid propolis-related components modulate all steps of the cancer progression process. Anticancer activity of propolis and its compounds relies on various mechanisms: cell-cycle arrest and attenuation of cancer cells proliferation, reduction in the number of cancer stem cells, induction of apoptosis, modulation of oncogene signaling pathways, inhibition of matrix metalloproteinases, prevention of metastasis, anti-angiogenesis, anti-inflammatory effects accompanied by the modulation of the tumor microenvironment (by modifying macrophage activation and polarization), epigenetic regulation, antiviral and bactericidal activities, modulation of gut microbiota, and attenuation of chemotherapy-induced deleterious side effects. Ingredients from propolis also ”sensitize“ cancer cells to chemotherapeutic agents, likely by blocking the activation of the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). In this review, we summarize the current knowledge related to the the effects of flavonoids and other polyphenolic compounds from propolis on tumor growth and metastasizing ability, and discuss possible molecular and cellular mechanisms involved in the modulation of inflammatory pathways and cellular processes that affect survival, proliferation, invasion, angiogenesis, and metastasis of the tumor.

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Section: Antitumor Activity Of Propolis and Its Polyphenolic/flavonoi...mentioning

confidence: 99%

Section: Antitumor Activity Of Propolis and Its Polyphenolic/flavonoi...mentioning

confidence: 99%

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Oršolić

Jembrek

2022

IJMS

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“…ERα is both a prognostic and predictive marker in BC, and hypermethylation of its promoter is a crucial gene‐silencing mechanism in ERα‐negative BC 32 . In ERα‐positive BC cell lines, such as MCF‐7, T47D, and ZR75‐1, the ESR1 promoter is considered nonmethylated 8,33 .…”

Section: Discussionmentioning

confidence: 99%

“…ERα is both a prognostic and predictive marker in BC, and hypermethylation of its promoter is a crucial gene‐silencing mechanism in ERα‐negative BC. 32 In ERα‐positive BC cell lines, such as MCF‐7, T47D, and ZR75‐1, the ESR1 promoter is considered nonmethylated. 8 , 33 Previously, a few EMT‐related transcriptional factors, such as Twist and ZEB1, were reported to induce hypermethylation of the ESR1 promoter and result in transcriptional repression of ERα.…”

Section: Discussionmentioning

confidence: 99%

Methylation of ESR1 promoter induced by SNAI2–DNMT3B complex promotes epithelial–mesenchymal transition and correlates with poor prognosis in ERα‐positive breast cancers

Li,

Deng,

Zhu

et al. 2023

MedComm

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Estrogen receptor α (ERα) serves as an essential therapeutic predictor for breast cancer (BC) patients and is regulated by epigenetic modification. Abnormal methylation of cytosine phosphoric acid guanine islands in the estrogen receptor 1 (ESR1) gene promoter could silence or decrease ERα expression. In ERα‐negative BC, we previously found snail family transcriptional repressor 2 (SNAI2), a zinc‐finger transcriptional factor, recruited lysine‐specific demethylase 1 to the promoter to transcriptionally suppress ERα expression by demethylating histone H3 lysine 4 dimethylation (H3K4me2). However, the role of SNAI2 in ERα‐positive BC remains elusive. In this study, we observed a positive correlation between SNAI2 and ESR1 methylation, and SNAI2 promoted ESR1 methylation by recruiting DNA methyltransferase 3 beta (DNMT3B) rather than DNA methyltransferase 1 (DNMT1) in ERα‐positive BC cells. Subsequent enrichment analysis illustrated that ESR1 methylation is strongly correlated with cell adhesion and junction. Knocking down DNMT3B could partially reverse SNAI2 overexpression‐induced cell proliferation, migration, and invasion. Moreover, high DNMT3B expression predicted poor relapse‐free survival and overall survival in ERα‐positive BC patients. In conclusion, this study demonstrated the novel mechanisms of the ESR1 methylation mediated with the SNAI2/DNMT3B complex and enhanced awareness of ESR1 methylation's role in promoting epithelial–mesenchymal transition in BC.

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“…MDA-MB-231 (ER-, PR-, and HER2-) cells express a higher Ki-67 expression contrary to MCF-F7 (ER+, PR+, and HER2-) cells and have been shown to have no p21 induction [ 112 ]. Employment of stilbenes like resveratrol to repress Ki-67 transcription might also be challenging because studies show that it prevents DNMT1 and MBD2 binding at the promoter of important oncogenes like BRCA1, thereby activating them [ 114 ]. The potential to make resveratrol work differentially, gene-to-gene, needs further research.…”

Section: Epigenetic Effect Of Stilbene On Genes and Proteins Related To Cell-proliferation And Metastasismentioning

confidence: 99%

Impact of Stilbenes as Epigenetic Modulators of Breast Cancer Risk and Associated Biomarkers

Ganguly

Arora

Tollefsbol

2021

IJMS

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With the recent advancement of genetic screening for testing susceptibility to mammary oncogenesis in women, the relevance of the gene−environment interaction has become progressively apparent in the context of aberrant gene expressions. Fetal exposure to external stressors, hormones, and nutrients, along with the inherited genome, impact its traits, including cancer susceptibility. Currently, there is increasing interest in the role of epigenetic biomarkers such as genomic methylation signatures, plasma microRNAs, and alterations in cell-signaling pathways in the diagnosis and primary prevention of breast cancer, as well as its prognosis. Polyphenols like natural stilbenes have been shown to be effective in chemoprevention by exerting cytotoxic effects that can stall cell proliferation. Besides possessing antioxidant properties against the DNA-damaging effects of reactive oxygen species, stilbenes have also been observed to modulate cell-signaling pathways. With the increasing trend of early-life screening for hereditary breast cancer risks, the potency of different phytochemicals in harnessing the epigenetic biomarkers of breast cancer risk demand more investigation. This review will explore means of exploiting the abilities of stilbenes in altering the underlying factors that influence breast cancer risk, as well as the appearance of associated biomarkers.

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Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer

Cited by 10 publications

References 117 publications

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Methylation of ESR1 promoter induced by SNAI2–DNMT3B complex promotes epithelial–mesenchymal transition and correlates with poor prognosis in ERα‐positive breast cancers

Impact of Stilbenes as Epigenetic Modulators of Breast Cancer Risk and Associated Biomarkers

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