Epigenetic regulation by quercetin: a comprehensive review focused on its biological mechanisms

Zhu, Jinfeng; Cheng, Xiaju; Naumovski, Nenad; Hu, Lin; Wang, Kai

doi:10.1080/10408398.2023.2278760

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2024

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Cited by 7 publications

References 214 publications

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Dietary components as epigenetic modifiers and their roles in cancer prevention

Thakur,

Saran

2024

Cancer Epigenetics and Nanomedicine

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Dietary components as epigenetic modifiers and their roles in cancer prevention

Thakur,

Saran

2024

Cancer Epigenetics and Nanomedicine

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Harnessing natural inhibitors of protein synthesis for cancer therapy: A comprehensive review

Liu,

Li,

2024

Pharmacological Research

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Polyphenol-based polymer nanoparticles for inhibiting amyloid protein aggregation: recent advances and perspectives

Fang,

Zhang,

Liu

et al. 2024

Front. Nutr.

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Polyphenols are a group of naturally occurring compounds that possess a range of biological properties capable of potentially mitigating or preventing the progression of age-related cognitive decline and Alzheimer’s disease (AD). AD is a chronic neurodegenerative disease known as one of the fast-growing diseases, especially in the elderly population. Moreover, as the primary etiology of dementia, it poses challenges for both familial and societal structures, while also imposing a significant economic strain. There is currently no pharmacological intervention that has demonstrated efficacy in treating AD. While polyphenols have exhibited potential in inhibiting the pathological hallmarks of AD, their limited bioavailability poses a significant challenge in their therapeutic application. Furthermore, in order to address the therapeutic constraints, several polymer nanoparticles are being explored as improved therapeutic delivery systems to optimize the pharmacokinetic characteristics of polyphenols. Polymer nanoparticles have demonstrated advantageous characteristics in facilitating the delivery of polyphenols across the blood–brain barrier, resulting in their efficient distribution within the brain. This review focuses on amyloid-related diseases and the role of polyphenols in them, in addition to discussing the anti-amyloid effects and applications of polyphenol-based polymer nanoparticles.

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Epigenetic regulation by quercetin: a comprehensive review focused on its biological mechanisms

Cited by 7 publications

References 214 publications

Dietary components as epigenetic modifiers and their roles in cancer prevention

Dietary components as epigenetic modifiers and their roles in cancer prevention

Harnessing natural inhibitors of protein synthesis for cancer therapy: A comprehensive review

Polyphenol-based polymer nanoparticles for inhibiting amyloid protein aggregation: recent advances and perspectives

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