Epigenetic regulation in epilepsy: A novel mechanism and therapeutic strategy for epilepsy

Chen, Shuang; Huang, Ming; Xu, Da; Li, Man

doi:10.1016/j.neuint.2023.105657

Cited by 4 publications

(1 citation statement)

References 234 publications

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“…These modifications play a crucial role in tRNA functionality, impacting protein synthesis and mitochondrial stability. Perturbations in these pathways may predispose individuals to neurological disorders such as epilepsy by influencing neuronal excitability and energy metabolism [224]. Mitochondrial disorders such as MELAS and MERRF are associated with compromised mt-tRNA modification.…”

Section: The Emerging Role Of Trna Dysregulation In Epilepsymentioning

confidence: 99%

tRNA Modifications and Dysregulation: Implications for Brain Diseases

Lv,

Zhang,

et al. 2024

Brain Sciences

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Transfer RNAs (tRNAs) are well-known for their essential function in protein synthesis. Recent research has revealed a diverse range of chemical modifications that tRNAs undergo, which are crucial for various cellular processes. These modifications are necessary for the precise and efficient translation of proteins and also play important roles in gene expression regulation and cellular stress response. This review examines the role of tRNA modifications and dysregulation in the pathophysiology of various brain diseases, including epilepsy, stroke, neurodevelopmental disorders, brain tumors, Alzheimer’s disease, and Parkinson’s disease. Through a comprehensive analysis of existing research, our study aims to elucidate the intricate relationship between tRNA dysregulation and brain diseases. This underscores the critical need for ongoing exploration in this field and provides valuable insights that could facilitate the development of innovative diagnostic tools and therapeutic approaches, ultimately improving outcomes for individuals grappling with complex neurological conditions.

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Section: The Emerging Role Of Trna Dysregulation In Epilepsymentioning

confidence: 99%

tRNA Modifications and Dysregulation: Implications for Brain Diseases

Lv,

Zhang,

et al. 2024

Brain Sciences

View full text Add to dashboard Cite

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Unraveling the genetic basis of epilepsy: Recent advances and implications for diagnosis and treatment

Dwivedi,

Kaushik,

Tripathi

et al. 2024

Brain Research

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Anti-epileptic activity of casticin phytoconstituent from Vitex negundo on validated animal model

Kumar,

Bais

2024

J. Drug Delivery Ther.

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This study investigates the antiepileptic potential of the methanolic extract of Vitex negundo leaves in seizure models induced in mice using lithium-pilocarpine, maximal electroshock (MES), strychnine, picrotoxin, and pentylenetetrazol. The extract demonstrated a protective effect against seizures induced by MES and enhanced the efficacy of standard anticonvulsant drugs against chemically-induced seizures. The results suggest that the flavonoids present in the methanolic extract may exert their antiepileptic effects by modulating GABAergic pathways and blocking sodium (Na⁺) channels in a dose-dependent manner. These findings highlight the potential of Vitex negundo methanolic extract as a promising therapeutic candidate for epilepsy treatment. Keywords: Vitex negundo, methanolic extract, maximal electroshock (MES), antiepileptic, animal models, GABAergic pathway

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Epigenetic regulation in epilepsy: A novel mechanism and therapeutic strategy for epilepsy

Cited by 4 publications

References 234 publications

tRNA Modifications and Dysregulation: Implications for Brain Diseases

tRNA Modifications and Dysregulation: Implications for Brain Diseases

Unraveling the genetic basis of epilepsy: Recent advances and implications for diagnosis and treatment

Anti-epileptic activity of casticin phytoconstituent from Vitex negundo on validated animal model

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