2022
DOI: 10.3390/biom12040513
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Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs

Abstract: Environmental factors, including pollutants and lifestyle, constitute a significant role in severe, chronic pathologies with an essential societal, economic burden. The measurement of all environmental exposures and assessing their correlation with effects on individual health is defined as the exposome, which interacts with our unique characteristics such as genetics, physiology, and epigenetics. Epigenetics investigates modifications in the expression of genes that do not depend on the underlying DNA sequenc… Show more

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Cited by 6 publications
(5 citation statements)
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“…The field of environmental epigenetics research has experienced a revolution due to the discovery of various ncRNA species, transforming our understanding of physiology and disease development ( Frye et al, 2021 ; Olmedo-Suárez et al, 2022 ; Rubio et al, 2023a ). ncRNAs, including miRNAs, piRNAs, and lncRNAs, play roles in biological processes by interacting with transcription factors and key regulatory proteins ( Mattick et al, 2023 ).…”
Section: General Characteristics Of Particulate Matter Subtypesmentioning
confidence: 99%
“…The field of environmental epigenetics research has experienced a revolution due to the discovery of various ncRNA species, transforming our understanding of physiology and disease development ( Frye et al, 2021 ; Olmedo-Suárez et al, 2022 ; Rubio et al, 2023a ). ncRNAs, including miRNAs, piRNAs, and lncRNAs, play roles in biological processes by interacting with transcription factors and key regulatory proteins ( Mattick et al, 2023 ).…”
Section: General Characteristics Of Particulate Matter Subtypesmentioning
confidence: 99%
“…Specifically, air pollution is defined as the release of harmful particles into the air by one or more harmful gases. The six main air pollutants are: airborne fine particulate matter 10 microns or less in diameter (PM10) and 2.5 microns or less in diameter (PM2.5); ozone, carbon monoxide, lead, nitrogen dioxide and sulfur dioxide [20,21]. Two main types of air pollution are considered: outdoor pollution as the pollution of the ambient air, and indoor pollution as the pollution generated by domestic combustion [20].…”
Section: Environmental Pollution and Its Impact On Epigeneticsmentioning
confidence: 99%
“…In recent years, scientific evidence linking air pollution with obesity has been published by international groups, proposing several key biological pathways acting as a functional bridge [24,27]. It is known that the exposome (exposure to environmental compounds and factors such as stress, habits, diet, exercise, lifestyle) can affect molecular pathways and cellular processes that increase the susceptibility to develop several diseases including obesity, because of abnormal epigenetic modifications [21,28]. Early in the forties, Conrad Waddington first introduced the term "epigenetics" to describe environment-gene interactions that could not be explained by traditional Mendelian genetics [29].…”
Section: Environmental Pollution and Its Impact On Epigeneticsmentioning
confidence: 99%
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“…Epigenetics is the study of heritable changes in gene expression that occur independently of alterations in DNA sequence. Epigenetic modifications affect molecular pathways during development, differentiation, and tumorigenesis, which are known to be triggered by age, diet, stress, hormones [ 38 , 39 , 40 ], as well as exposure to other environmental stimuli or factors known as exposome, as recently shown to significantly influence epigenetic modification [ 41 ]. Moreover, epigenetic alterations can be inherited through cell divisions and, in some cases, can be maintained over long periods of time or transmitted down through generations [ 42 , 43 ].…”
Section: Epigenetic Modifications In Breast Cancermentioning
confidence: 99%