Epigenetic Regulation of Gene Expression in Head and Neck Squamous Cell Carcinoma: Therapeutic Perspectives

Samsonov, Roman; Раджабова, З. А.; Чебуркин, Ю. В.; Клюге, В. А.; Tkachenko, Elena; Malek, Anastasia

doi:10.17650/2222-1468-2016-6-4-35-44

Cited by 2 publications

(1 citation statement)

References 88 publications

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“…На сегодняшний день молекулярно-биологические исследования выходят на качественно новый уровень. Значительное внимание уделяется изучению эпигенетических механизмов контроля опухолевой прогрессии, в том числе регуляции экспрессии интегринов αv различными микроРНК [56][57][58]. Результатом совместной работы врачей-исследователей и онкологов является грамотное внедрение достижений фундаментальной медицины в клиническую практику.…”

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The role of integrins αv in the pathogenesis of oral squamous cell carcinoma

Tuguzbaeva¹,

Павлов²

2019

Usp. mol. onkol

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The initiation of carcinoma progression is attributed to significant disorders in the synthesis of macromolecules that affect physiological processes in the epithelial cells of oral mucosa. It is known that the integrin family receptors are crucial for regenerative and reparative functions of the normal epithelium. In addition to their well-established physiological role, some types of integrins are the major determinants of malignant transformations. In particular, the results of recent studies in molecular oncology reveal the importance of αv integrins in the pathogenesis of carcinomas, including oral squamous cell carcinoma. This review aims to analyse the significance of αv integrins in the key processes of malignant growth and metastasis of oral squamous cell carcinoma. The prospects of using αv integrins as prognostic molecular markers and targets for developing novel diagnostic and therapeutic methods in the management of oral cancer are discussed.

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Section: заключениеunclassified

The role of integrins αv in the pathogenesis of oral squamous cell carcinoma

Tuguzbaeva¹,

Павлов²

2019

Usp. mol. onkol

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Assessment of the Impact of Inaccuracies in the Head and Neck Tumors Patient Positioning on the Halcyon Accelerator by the Amount of Dose-Volumetric Characteristics When Planning Radiotherapy

Bessarabova,

Mikhailova,

Lebedenko

et al. 2023

Med. fiz.

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Purpouse. To evaluate the impact of inaccuracies in patient positioning during irradiation of tumors in the head and neck region under the control of a portal imaging device on the Halcyon accelerator on the value of CTV-PTV offsets at the contouring stage. Material and methods. Treatment of patients and monitoring of the position of 35 patients on the therapeutic table using a portal visualization device during each irradiation session was carried out on a Halcyon tunnel-type electron accelerator, including an irradiation planning system (Eclipse version 16.1) and the Aria oncology information system (version 15.5). Resuits. Based on the results of positioning and analysis of a sample of 35 patients, it was concluded that it is possible to change the CTV-PTV offsets during contouring to a smaller side for the head area and a larger one for the neck area below the C3 vertebra. These results are explained by the strong fixation of the head in the thermoplastic mask, and the high mobility of the neck due to air gaps. Conclusions. When creating a treatment plan, changing the CTV PTV offsets leads to a reduction in the volume of the target and moving it away from critical structures. This makes it possible to increase the accuracy of the treatment and reduce the dose load on the normal tissues surrounding the tumor. The results obtained have high practical value.

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Epigenetic Regulation of Gene Expression in Head and Neck Squamous Cell Carcinoma: Therapeutic Perspectives

Cited by 2 publications

References 88 publications

The role of integrins αv in the pathogenesis of oral squamous cell carcinoma

The role of integrins αv in the pathogenesis of oral squamous cell carcinoma

Assessment of the Impact of Inaccuracies in the Head and Neck Tumors Patient Positioning on the Halcyon Accelerator by the Amount of Dose-Volumetric Characteristics When Planning Radiotherapy

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