Epigenetic reprogramming during spermatogenesis and male factor infertility

McSwiggin, Hayden; O’Doherty, Alan M.

doi:10.1530/rep-18-0009

Cited by 71 publications

(63 citation statements)

References 162 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Any exposure to a deleterious environment may change DNA methylation patterns in male germ cells and interfere with differentiation into functional sperm cells, ultimately impairing male fertility. In line with this, numerous studies in humans and model species have reported changes to sperm DNA methylation in the context of spermatogenesis defects, male infertility, and exposure to toxins or nutritional challenges (Boissonnas et al 2013;Schagdarsurengin and Steger 2016;McSwiggin and O'Doherty 2018).…”

Section: Introductionmentioning

confidence: 68%

DNA methylation in bull spermatozoa: evolutionary impacts, interindividual variability, and contribution to the embryo

Kiefer

Perrier

2020

Can. J. Anim. Sci.

View full text Add to dashboard Cite

The DNA methylome of spermatozoa results from a unique epigenetic reprogramming crucial for chromatin compaction and the protection of the paternal genetic heritage. Although bull semen is widely used for artificial insemination (AI), little is known about the sperm epigenome in cattle. The purpose of this review is to synthetize recent work on the bull sperm methylome in light of the knowledge accumulated in humans and model species. We will address sperm-specific DNA methylation features and their potential evolutionary impacts, with particular emphasis on hypomethylated regions and repetitive elements. We will review recent examples of interindividual variability and intra-individual plasticity of the bull sperm methylome as related to fertility and age, respectively. Finally, we will address paternal methylome reprogramming after fertilization, as well as the mechanisms potentially involved in epigenetic inheritance, and provide some examples of disturbances that alter the dynamics of reprogramming in cattle. Because the selection of AI bulls is closely based on their genotypes, we will also discuss the complex interplay between sequence polymorphism and DNA methylation, which represents both a difficulty in addressing the role of DNA methylation in shaping phenotypes and an opportunity to better understand genome plasticity.

show abstract

Section: Introductionmentioning

confidence: 68%

DNA methylation in bull spermatozoa: evolutionary impacts, interindividual variability, and contribution to the embryo

Kiefer

Perrier

2020

Can. J. Anim. Sci.

View full text Add to dashboard Cite

show abstract

“…Two recent meta‐analyses have linked human male obesity to reduced rates of clinical pregnancy and live births following ART, while a third found no evidence for a relationship between male BMI and treatment outcomes of ART . Negative effects of male obesity on embryo development have been detected in both human ART cohort studies and animal high‐fat diet studies, indicating that sperm can transmit detrimental factors to offspring that impair development . In addition, there is compelling evidence that offspring can inherit metabolic disease from their fathers via epigenetic mechanisms (reviewed in previous studies).…”

Section: Discussionmentioning

confidence: 99%

High‐fat diets reduce male reproductive success in animal models: A systematic review and meta‐analysis

Crean

Senior

2019

Obesity Reviews

View full text Add to dashboard Cite

Sperm counts have shown a progressive decline across the world since the mid-1900s. Global rates of obesity have been climbing at a similarly alarming rate, suggesting that these two factors may be linked. However, studies examining the relationship between body mass index (BMI) and male fertility have produced conflicting results.These discrepancies among studies are commonly attributed to limitations that are inherent in human studies such as correlational data and confounding factors-limitations that are absent from animal studies. Hence, we conducted a systematic review and meta-analysis of animal studies that experimentally induced obesity with a high-fat diet and measured impacts on sperm traits and/or male fertility. Overall, we found strong, consistent evidence in animal studies that high-fat diets are detrimental for male fertility. Compared with controls, males fed a high-fat diet had smaller testes and sex accessory glands relative to body size, reduced semen quality, reduced mating success, and reduced fertilization success. This is the first time that experimental data of high-fat diet effects on male reproduction have been synthesized in a metaanalysis, and thus, our results provide novel insight to the complex question of how dietary-induced obesity affects male fertility. The strong negative effects detected in animal models suggest that the inconsistent results plaguing human studies are an artefact of limitations inherent in correlational studies rather than a true effect.

show abstract

“…Establishment of totipotency is initiated upon fertilization with the formation of the zygote. differentiation into sperm, during which genomic DNA becomes transcriptionally silent, highly methylated, and packaged with protamines into a highly condensed configuration [33].…”

Section: Nucleolus Structures and Rrna Genes In Gametogenesismentioning

confidence: 99%

Nucleolus and rRNA Gene Chromatin in Early Embryo Development

Kresoja‐Rakic

Santoro

2019

Trends in Genetics

View full text Add to dashboard Cite

The nucleolus is the largest substructure in the nucleus and forms around the nucleolar organizer regions (NORs), which comprise hundreds of rRNA genes. Recent evidence highlights further functions of the nucleolus that go beyond ribosome biogenesis. Data indicate that the nucleolus acts as a compartment for the location and regulation of repressive genomic domains and, together with the nuclear lamina, represents the hub for the organization of the inactive heterochromatin. In this review, we discuss recent findings that have revealed how nucleolar structure and rRNA gene chromatin states are regulated during early mammalian development and their contribution to the higher-order spatial organization of the genome. The Multifunctional Nucleolus: From Ribosome Producer to Organizer of Genome Architecture The nucleolus (see Glossary) is the largest subnuclear compartment of the cell and forms around regions of chromosomes containing stretches of tandem repetitive rRNA genes, known as nucleolar organizer regions (NORs). The nucleolus is responsible for the production of ribosomes, a highly regulated process that is essential for growth and development. Ribosome biogenesis is initiated in the nucleolus by RNA polymerase I (Pol I), which, together with a dedicated set of basal transcription factors, such as TIF1A, the TBP-TAFI complex SL1, and the DNA architectural upstream binding factor (UBF) [1,2], transcribes hundreds of rRNA genes to generate 45S/47S pre-rRNA in mammalian cells (Figure 1A). This rRNA precursor is chemically modified and processed to form 28S, 18S, and 5.8S rRNAs, which are then assembled with ribosomal proteins and 5S rRNA and exported from the nucleus to give rise to active ribosomes in the cytoplasm [3]. Increasing evidence suggests that the function of the nucleolus and rRNA genes goes beyond ribosome biogenesis. One aspect that has received significant interest over the past decade is the link between the nucleolus and rRNA genes with the organization of genome architecture. Clustering of heterochromatin at nucleoli is a phenomenon that occurs in all cells. Furthermore, regions located close to the nucleolus (nucleolar-associated domains, NADs) have low gene densities, low transcriptional levels, and repressive histone modifications [4-8]. Since similar heterochromatic and repressive regions are also located to the nuclear lamina, the nucleolus, together with the nuclear lamina, can be considered the hub for the organization of the inactive chromatin in the cell [8-10]. In this review, we address the role of the nucleolus as a subnuclear compartment for the organization of heterochromatin. We discuss recent findings that have revealed how nucleolar structure and rRNA gene chromatin states are regulated during gametogenesis and early mammalian development, and their contribution in the higher-order spatial organization of the genome. Nucleolus and rRNA Genes in Somatic Cells In somatic cells, the nucleolus is a membraneless compartment with a peculiar tripartite architecture: the fibrillar cen...

show abstract

Epigenetic reprogramming during spermatogenesis and male factor infertility

Cited by 71 publications

References 162 publications

DNA methylation in bull spermatozoa: evolutionary impacts, interindividual variability, and contribution to the embryo

DNA methylation in bull spermatozoa: evolutionary impacts, interindividual variability, and contribution to the embryo

High‐fat diets reduce male reproductive success in animal models: A systematic review and meta‐analysis

Nucleolus and rRNA Gene Chromatin in Early Embryo Development

Contact Info

Product

Resources

About