Epigenetic Roles of Microbiota and Aloe vera in Health and Disease

Abstract

Our healthspan is to a great extent epigenetically determined by diets, lifestyle, and various other environmental factors. Gut microbiota has been proven to be the major player in maintaining human health. Our previous report described health benefits of long-term ingestion of aloe vera gel through the modification of the intestinal microbiota. In the present review, we broadly cover the topics of microbiota and aloe vera gel ingestion related to attenuation of reactive oxygen species, prevention of cardiovascular disorders, effects of lifeprolonging calorie restriction. Additional data are summarized on prophylactic actions of fermented butyrate, and aloe-emodin related components against obesity. Prophylactic actions of aloe vera gel on healthy aging, skin photo-aging, and the viability and lifespan in Drosophila melanogaster are discussed in relation to the properties of butyrate and its potential effects involved in health and disease.

Bioprospecting of endophytes in medicinal plants of Thar Desert: An attractive resource for biopharmaceuticals

“…Approximately 75 natural products are produced by Aloe vera [ 102 ]. It exhibited high inhibitory activity against elastin and α-amylase activities, and mild inhibition on neuraminidase and lipase activities [ 103 ]. A total of 129 bacterial endophytes representing ten genera grouped into four classes were isolated of which thirty-two isolates were identified on the basis of genetic similarity namely, Enterobacter sp.…”